Neutral 17-Ketosteroids in Porcine Urine

Veld, L. G. Huis in 't; Louwerens, B.; Reilingh, W

doi:10.1038/191175a0

Cited by 6 publications

(2 citation statements)

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“…The occurrence of dehydroepiandrosterone (D) and/or the parent sulphate ester (DS) has been demonstrated in the rat (Jungmann 1968a,-Askari et al 1970, guinea pig (Trout et al 1967; Jones 8c Griffiths 1968), rabbit b), dog (Oertel 8c Eik-Nes 1959;Eik-Nes 8c Hall 1962;DePaoli 8c Eik-Nes 1963), sheep (Pierrepoint et al 1971), pig (Neher 8c Wettstein 1960;Huis int Veld et al 1961;Ruokonen 8c Vihko 1974) and cow (Jungmann 1968¿>). Evidence for the presence of androsterone (A) and/or androsterone sulphate (AS) in the rat (Schubert 8c Weinberger 1962;Maynard 8c Cameron 1971Milewich 8c Axelrod 1972) and pig (Clark el al.…”

Section: Discussionmentioning

confidence: 99%

Free and Solvolysable Dehydroepiandrosterone and Androsterone in Blood of Mammals Under Physiological Conditions and Following Administration of Dehydroepiandrosterone

Fehér

Bodrogi

Fehér

et al. 1977

Acta Endocrinologica

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A gas chromatographic method has been employed for the determination of dehydroepiandrosterone (D), androsterone (A), dehydroepiandrosterone sulphate (DS) and androsterone sulphate (AS) in the peripheral blood of human subjects and in various mammals under physiological conditions and after the administration of D or DS. Unconjugated D has been isolated and the resting level determined in the rat, rabbit, dog, sheep, pig and cow, while DS was detectable in the peripheral circulation of the rat, dog and pig. Unconjugated A was present in blood of the rodents and domestic ungulates studied, while the parent sulphate could be demonstrated only in rat, dog, pig and cow. The plasma of lower mammals contained D in higher (0.8\p=n-\10.9 \g=m\g/100ml), and DS, if any, in lower level (1.5\p=n-\5.7 \g=m\g/100ml) than the human plasma samples (0.1\p=n-\2.7 and 86\p=n-\308 \g=m\g/100ml, respectively). There was a more pronounced increase in D and A than in the DS and AS level in the rat and dog following administration of D. On the contrary, exogenous D hardly affected unconjugated D and appreciably enhanced the DS level in human plasma. The conclusion drawn for human subjects, that D is the metabolically active and DS the reserve hormone, does not seem to be valid for all the animals here studied. 126

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Section: Discussionmentioning

confidence: 99%

Free and Solvolysable Dehydroepiandrosterone and Androsterone in Blood of Mammals Under Physiological Conditions and Following Administration of Dehydroepiandrosterone

Fehér

Bodrogi

Fehér

et al. 1977

Acta Endocrinologica

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“…hcg (Pregnyl; Organon Inc., Montreal) was administered, was carried out as previously described (Liptrap & Raeside, 1971). The excretion values for DFIA (3\g=b\-hydroxyandrost-5-en-17-one), which is of testicular origin in the boar (Huis in't Veld, Louwerens & Reilingh, 1961), were determined as described by Raeside (1965). The results for total oestrogens in the urine samples were estimated with the procedure outlined by Raeside (1963).…”

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confidence: 99%