1989
DOI: 10.1152/jappl.1989.66.6.2653
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Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections

Abstract: Neuropeptides such as substance P are implicated in inflammation mediated by sensory nerves (neurogenic inflammation), but the roles in disease of these peptides and the peptidases that degrade them are not understood. It is well established that inflammation is a prominent feature of several airway diseases, including viral infections, asthma, bronchitis, and cystic fibrosis. These diseases are characterized by cough, airway edema, and abnormal secretory and bronchoconstrictor responses, all of which can be e… Show more

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Cited by 118 publications
(70 citation statements)
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“…Support for this reasoning is given by studies showing that viral infections enhance the contractile responses to SP in guinea-pig bronchi (Saban et al, 1987) and ferret trachea (Jacoby et al, 1988). Furthermore, histories of infections in rats have been associated with a decreased activity of NEP and an enhanced SP-induced vascular leakage in the trachea (Borson et al, 1989).…”
Section: Discussionmentioning
confidence: 97%
“…Support for this reasoning is given by studies showing that viral infections enhance the contractile responses to SP in guinea-pig bronchi (Saban et al, 1987) and ferret trachea (Jacoby et al, 1988). Furthermore, histories of infections in rats have been associated with a decreased activity of NEP and an enhanced SP-induced vascular leakage in the trachea (Borson et al, 1989).…”
Section: Discussionmentioning
confidence: 97%
“…The results imply that there is continuous release of tachykinins and kinins and that NEP maintains low basal levels of these peptides. These findings are of possible clinical interest, since NEP is down-regulated in inflamed tissues, which may contribute to uncontrolled inflammation [40,41].…”
Section: Degradation Of Peptide Hormones and Neurotransmittersmentioning
confidence: 94%
“…Similarly, respiratory infections of rodents with Sendai virus (parainfluenza type 1) can potentiate substance P-induced increases in airways blood flow (78) and enhance tachykinergic nerve-mediated contraction of airway smooth muscle (79). These effects appear to be at least partially due to decreased activity of neutral endopeptidase, a protease normally present in the airways, which degrades tachykinins (80)(81)(82).…”
Section: Enhanced Release Of Tachykininsmentioning
confidence: 99%