Neutralizing activity in the serum and oesophageal-pharyngeal fluid of cattle after exposure to foot-and-mouth disease virus and subsequent re-exposure

McVicar, J. W.; Sutmöller, P.

doi:10.1007/bf01250231

Cited by 28 publications

(16 citation statements)

References 7 publications

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“…Neutralizing activity in cattle infected by nasal spray exposure was reported for nasal fluids and saliva 10 and 21 days after nasal spray infection, respectively (13), and around 2 weeks after instillation for OPF samples (18). An even earlier report by Kaaden and Matthaeus (16) revealed a poor correlation between serum and saliva neutralization titers, with IgA as the predominant isotype in salivary secretions.…”

Section: Discussionmentioning

confidence: 94%

“…The detection of specific neutralizing antibodies in oronasal and esophageal-pharyngeal fluids has previously been described for cattle infected by oronasal routes with different FMDV O1 strains (13,15,18). All of these reports were based on results obtained starting at least 1 week after the experimental infections.…”

Section: Discussionmentioning

confidence: 99%

“…In an early report, Figueroa et al (13) reported neutralizing activity in samples of saliva and nasal fluids taken from cattle infected by FMDV administered by intranasal spray. Later, McVicar and Sutmoller (18), also using an intranasal route for infection, detected neutralizing antibodies in saliva and OPF, suggesting a putative independence between the local response and the antibody response detected in serum. Other reports also showed the detection of FMDV-specific IgM and IgA in pharyngeal fluids 1 week after infection, but they proposed a systemic origin for these antibodies (14,20).…”

mentioning

confidence: 99%

“…The detection of adaptive immune responses at the local level after natural or experimental infection of cattle was performed in the past through the detection of secretory immunoglobulins in the oronasal cavities and esophageal-pharyngeal fluids (OPF), and most of the time these efforts were focused on the discovery of markers of infection or a carrier state (13)(14)(15)(16)(17)(18)(19). In an early report, Figueroa et al (13) reported neutralizing activity in samples of saliva and nasal fluids taken from cattle infected by FMDV administered by intranasal spray.…”

mentioning

confidence: 99%

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Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle

Pega

Bucafusco

Giacomo

et al. 2013

J Virol

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Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase in the respiratory tract for up to 72 h postinfection, followed by hematogenous dissemination and vesicular lesions at oral and foot epithelia. The role of the early local adaptive immunity of the host in the outcome of the infection is not well understood. Here we report the kinetics of appearance of FMDV-specific antibody-secreting cells (ASC) in lymphoid organs along the respiratory tract and the spleen in cattle infected by aerosol exposure. While no responses were observed for up to 3 days postinfection (dpi), all animals developed FMDV-ASC in all the lymphoid organs studied at 4 dpi. Tracheobronchial lymph nodes were the most reactive organs at this time, and IgM was the predominant isotype, followed by IgG1. Numbers of FMDV-ASC were further augmented at 5 and 6 dpi, with an increasing prevalence in upper respiratory organs. Systemic antibody responses were slightly delayed compared with the local reaction. Also, IgM was the dominant isotype in serum at 5 dpi, coinciding with a sharp decrease of viral RNA detection in peripheral blood. These results indicate that following aerogenous administration, cattle develop a rapid and vigorous genuine local antibody response throughout the respiratory tract. Time course and isotype profiles indicate the presence of an efficient T cell-independent antibody response which drives the IgM-mediated virus clearance in cattle infected by FMDV aerosol exposure.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle

Pega

Bucafusco

Giacomo

et al. 2013

J Virol

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“…Tests for antibodies against non-structural proteins (10,16,54,61) cannot be used because some virus carriers do not show seroconversion for these proteins (40,61). McVicar and Sutmoller (46) concluded that neutralizing antibody titres remain higher in OPF and serum of persistently infected animals than in animals that have cleared the virus: -Titres remain about 1 log10 higher for at least 28 days after infection. When tested in an IgA antibody capture ELISA (ACA), IgA titres in probang samples remained detectable for at least 200 days after infection in persistently infected animals, whereas antibodies were hardly detectable in so-called 'eliminators' (57).…”

Section: Occurrence and Detection Of Carrier Animalsmentioning

confidence: 99%

Carriers of foot‐and‐mouth disease virus: A review

Moonen¹,

Schrijver²

2000

Veterinary Quarterly

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This review describes current knowledge about persistent foot-and-mouth disease virus (FMDV) infections, the available methods to detect carrier animals, the properties of persisting virus, the immunological mechanisms, and the risk of transmission. In particular, knowledge about the carrier state, the period in which virus can be isolated from animals 28 days or longerpost infection, is important, because the risk that animals may carry the virus will influence the diagnostic and preventive measures that need to be taken. Although many years of research have led to much knowledge about foot-andmouth disease and its causative agent, there are still numerous aspects of the virus and the disease that are not yet fully understood. Areas for further research on persistence of FMDV are discussed.

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Interplay of foot and mouth disease virus with cell‐mediated and humoral immunity of host

Abubakar¹,

Manzoor²,

Ahmed³

2017

Reviews in Medical Virology

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Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell-mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survival and spread. The viral leader proteinase, L pro, deters interferon beta (IFN-β) mRNA synthesis, thus, inhibiting host cell translation. Another viral proteinase, 3C pro, disrupts host cell transcription by cleaving histone H3. A transient lymphopenia in swine as a consequence of FMDV infection has also been observed, but the mechanism involved and viral protein(s) associated with this process are not clearly understood. In this review, we have covered the interaction of FMDV with different immune cells including lymphocytes and antigen presenting cells and their consequences.

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Neutralizing activity in the serum and oesophageal-pharyngeal fluid of cattle after exposure to foot-and-mouth disease virus and subsequent re-exposure

Cited by 28 publications

References 7 publications

Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle

Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle

Carriers of foot‐and‐mouth disease virus: A review

Interplay of foot and mouth disease virus with cell‐mediated and humoral immunity of host

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