Neutralizing effect of green tea epigallocatechin‐3‐gallate on nicotine‐induced toxicity and chemokine (C‐C motif) ligand 5 secretion in human oral epithelial cells and fibroblasts

Desjardins, Jacynthe; Grenier, Daniel

doi:10.1111/j.2041-1626.2011.00103.x

Cited by 16 publications

(17 citation statements)

References 56 publications

(109 reference statements)

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“…Evidence from mechanistic studies on green tea indicates that the high EGCG content has anti‐oxidant, anti‐microbial and anti‐collagenase effects, all of which could help to prevent periodontal diseases (Venkateswara et al . ) and smoking‐related gum disease (Desjardins & Grenier ).…”

Section: Methodsmentioning

confidence: 99%

“…Black and green teas are thought to have anti-cariogenic effects through reducing inflammation and preventing the adhesion and growth of bacteria linked with periodontal disease (Hamilton-Miller 2001;Chatterjee et al 2010). Evidence from mechanistic studies on green tea indicates that the high EGCG content has anti-oxidant, anti-microbial and anti-collagenase effects, all of which could help to prevent periodontal diseases (Venkateswara et al 2011) and smoking-related gum disease (Desjardins & Grenier 2012).…”

Section: Oral Healthmentioning

confidence: 99%

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Emerging evidence for tea benefits

Ruxton¹

2013

Nutrition Bulletin

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Summary Tea is the most commonly consumed beverage in the world, after water. Associations between regular tea drinking and a reduced risk of coronary heart disease are well established. The mechanism may relate to bioactive compounds found in tea, which exert anti‐arteriosclerotic, anti‐oxidative and anti‐inflammatory effects. However, evidence for other diverse health benefits is emerging. The aim of this review was to evaluate research on three new areas of interest in relation to tea drinking: (1) weight management (and glycaemic control); (2) oral health; and (3) gut health. Databases were searched for meta‐analytical, human intervention and epidemiological studies published between 1990 and 2013. For weight management, modest, positive effects were found for green tea when ingested by overweight/obese adults, possibly related to thermogenic effects. Epidemiological studies indicate that tea drinking in general may protect against tooth loss, certain oral/digestive cancers and Helicobacter pylori infection, although the studies were few in number with differing methodologies. A growing body of mechanistic studies suggests that tea has anti‐cariogenic, anti‐adhesive, anti‐bacterial and possible pre‐biotic effects – all with the potential to impact positively on the pathogenesis of chronic diseases. Clearly, larger trials are needed to confirm these effects in humans and establish optimal intakes. In the meantime, tea drinking appears to be a simple and beneficial way to support health.

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Section: Methodsmentioning

confidence: 99%

Section: Oral Healthmentioning

confidence: 99%

Emerging evidence for tea benefits

Ruxton¹

2013

Nutrition Bulletin

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“…Both in vitro and in vivo administration of green tea in smokers improved the levels of anti‐oxidant enzymes in saliva . Recently, the effects of EGCG on the nicotine‐induced toxic and inflammatory responses in oral epithelial cells and gingival fibroblasts were investigated . Nicotine was used either alone or in combination with the lipopolysaccharide of Aa.…”

Section: Green Tea As a Functional Food For Oral Health In Older Adultsmentioning

confidence: 99%

“…Nicotine was used either alone or in combination with the lipopolysaccharide of Aa. It was found that pretreatment of cells with EGCG neutralized the nicotine‐induced toxicity in epithelial cells and fibroblasts . It even inhibited acrolein induced apoptosis in human gingival fibroblasts …”

Section: Green Tea As a Functional Food For Oral Health In Older Adultsmentioning

confidence: 99%

“…68 Recently, the effects of EGCG on the nicotineinduced toxic and inflammatory responses in oral epithelial cells and gingival fibroblasts were investigated. 71 Nicotine was used either alone or in combination with the lipopolysaccharide of Aa. It was found that pretreatment of cells with EGCG neutralized the nicotineinduced toxicity in epithelial cells and fibroblasts.…”

Section: Need For Functional Foods In Older Adultsmentioning

confidence: 99%

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Green tea: A novel functional food for the oral health of older adults

Gaur

Agnihotri

2013

Geriatrics Gerontology Int

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Functional foods are foods with positive health effects that extend beyond their nutritional value. They affect the function of the body and help in the management of specific health conditions. Green tea, a time-honoured Chinese herb, might be regarded as a functional food because of its inherent anti-oxidant, anti-inflammatory, antimicrobial and antimutagenic properties. They are attributed to its reservoir of polyphenols, particularly the catechin, epigallocatechin-3-gallate. Owing to these beneficial actions, this traditional beverage was used in the management of chronic systemic diseases including cancer. Recently, it has been emphasized that the host immuno-inflammatory reactions destroy the oral tissues to a greater extent than the microbial activity alone. Green tea with its wide spectrum of activities could be a healthy alternative for controlling these damaging reactions seen in oral diseases, specifically, chronic periodontitis, dental caries and oral cancer, which are a common occurrence in the elderly population.

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