Neutrons from fragmentation of light nuclei in tissue-like media: a study with the GEANT4 toolkit

Pshenichnov, I.; Mishustin, I. N.; Greiner, Walter

doi:10.1088/0031-9155/50/23/005

Cited by 54 publications

(47 citation statements)

References 40 publications

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“…4. In this figure, our calculated LET is compared with the predictions of the MCHIT model [8,9,10] based on the GEANT4 toolkit [11,12]. The Monte Carlo calculations were performed both with and without taking into account nuclear fragmentation reactions.…”

Section: Ion Passage Through the Mediummentioning

confidence: 99%

“…Nuclear processes, mainly fragmentation reactions, result in the transformation of the beam particles into new species. The nuclear processes can be reliably modeled with the use of Monte-Carlo simulations, in particular by means of the MCHIT model [8,9,10] based on the GEANT4 toolkit [11,12]. Therefore in this paper, we only comment on projectile fragmentation processes without considering them in detail.…”

Section: Introductionmentioning

confidence: 99%

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Ion-induced electron production in tissue-like media and DNA damage mechanisms

et al. 2008

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Abstract. We propose an inclusive approach for calculating characteristics of secondary electrons produced by ions/protons in tissue-like media. This approach is based on an analysis of the projectile's interaction with the medium on the microscopic level. It allows us to obtain the energy spectrum and abundance of secondary electrons as functions of the projectile kinetic energy. The physical information obtained in this analysis is related to biological processes responsible for the irrepearable DNA damage induced by the projectile. In particular, we consider double strand breaks of DNA caused by secondary electrons and free radicals, and local heating in the ion's track. The heating may enhance the biological effectiveness of electron/free radical interactions with the DNA and may even be considered as an independent mechanism of DNA damage. Numerical estimates are performed for the case of carbon-ion beams. The obtained dosedepth curves are compared with results of the MCHIT model based on the GEANT4 toolkit.PACS. 61.80.-x Physical radiation effects, radiation damage -87.53.-j Effects of ionizing radiation on biological systems -41.75.Aki Positive-ion beams -34.50.Bw Energy loss and stopping power

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Section: Ion Passage Through the Mediummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ion-induced electron production in tissue-like media and DNA damage mechanisms

et al. 2008

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“…In our recent paper (Pshenichnov et al 2005) we have made a first attempt to validate the GEANT4 toolkit of version 7.0 (GEANT4-Webpage 2006) for heavy-ion therapy simulations. We have developed a GEANT4-based application for Monte Carlo simulations of Heavy-Ion Therapy (MCHIT).…”

Section: Introductionmentioning

confidence: 99%

Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4

2006

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Abstract.Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of 11 C, 10 C and 15 O nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e + annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in surrounding medium. A finite spatial resolution of the Positron Emission Tomography (PET) is taken into account in a simplified way. Depth distributions of β + -activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The calculated β + -activity profiles are in good agreement with PET data for proton and 12 C beams at energies suitable for particle therapy. The MCHIT capability to predict the β + -activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.

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“…60 Therefore, the possibility of delivering large and uniform dose dis-61 tributions makes of ion beams a suitable technique for external 62 radiation therapy in which the preservation of organs proximal 63 to the target and the sparing of critical structures distal to the tar-64 get are crucial [4]. 65 In order to achieve high precision in hadron therapy treatment [9], PHITS [10], GEANT4 [11], FLUKA [12], KURBUC [13] or MCHIT 96 [14]. Monte Carlo calculations prove that proton dose distribution 97 not only depends on electromagnetic interactions with target elec-98 trons, but also on nuclear interactions, such as fragmentation reac-99 tions and multiple scattering interactions [14][15][16].…”

mentioning

confidence: 99%

“…65 In order to achieve high precision in hadron therapy treatment [9], PHITS [10], GEANT4 [11], FLUKA [12], KURBUC [13] or MCHIT 96 [14]. Monte Carlo calculations prove that proton dose distribution 97 not only depends on electromagnetic interactions with target elec-98 trons, but also on nuclear interactions, such as fragmentation reac-99 tions and multiple scattering interactions [14][15][16]. 100 The aim of this work is to obtain accurate three-dimensional is made [19,20].…”

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confidence: 99%