Neutrophil antigen exposure is altered with age in relatives of patients with Type 2 diabetes

Rawling, L; Advani, Andrew; Marshall, Sally M.; Thomas, T.H.

doi:10.1007/s00125-003-1290-6

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…However, most of the research about neutrophil–endothelial cell adhesion in diabetes have focused on the development of atherosclerosis‐mediated diseases, such as diabetic microvascular and macrovascular complications, and studies about neutrophil–endothelial cell adhesion in type 1 diabetes pathogenesis are relatively scarce. Several endothelial adhesion molecules, such as intercellular adhesion molecule‐1 (ICAM‐1), CD62E, CD62P and vascular adhesion molecule‐1 (VCAM‐1), can attract circulating neutrophils then bind with neutrophil adhesion molecules. It has been shown that ICAM‐1, which is the best characterized cell surface adhesion molecule, is implicated in the pathogenesis of type 1 diabetes by being involved in the extravasation of leukocytes from the circulation into the inflamed pancreas.…”

Section: Cell–cell Interactions In Type 1 Diabetesmentioning

confidence: 99%

Neutrophils in type 1 diabetes

Huang

Xiao

et al. 2016

J of Diabetes Invest

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Type 1 diabetes is an autoimmune disease that afflicts millions of people worldwide. It occurs as the consequence of destruction of insulin‐producing pancreatic β‐cells triggered by genetic and environmental factors. The initiation and progression of the disease involves a complicated interaction between β‐cells and immune cells of both innate and adaptive systems. Immune cells, such as T cells, macrophages and dendritic cells, have been well documented to play crucial roles in type 1 diabetes pathogenesis. However, the particular actions of neutrophils, which are the most plentiful immune cell type and the first immune cells responding to inflammation, in the etiology of this disease might indeed be unfairly ignored. Progress over the past decades shows that neutrophils might have essential effects on the onset and perpetuation of type 1 diabetes. Neutrophil‐derived cytotoxic substances, including degranulation products, cytokines, reactive oxygen species and extracellular traps that are released during the process of neutrophil maturation or activation, could cause destruction to islet cells. In addition, these cells can initiate diabetogenic T cell response and promote type 1 diabetes development through cell–cell interactions with other immune and non‐immune cells. Furthermore, relevant antineutrophil therapies have been shown to delay and dampen the progression of insulitis and autoimmune diabetes. Here, we discuss the relationship between neutrophils and autoimmune type 1 diabetes from the aforementioned aspects to better understand the roles of these cells in the initiation and development of type 1 diabetes.

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Section: Cell–cell Interactions In Type 1 Diabetesmentioning

confidence: 99%

Neutrophils in type 1 diabetes

Huang

Xiao

et al. 2016

J of Diabetes Invest

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“…It therefore remains unclear whether the defect in SMCE is specific to Type 2 diabetes or related to the presence of an associated metabolic abnormality. Storemediated calcium entry is a cytoskeletal-dependent process and we have recently reported the same cytoskeletal defect in first-degree relatives of patients with Type 2 diabetes as that observed in the patients themselves [35]. Study of the response in neutrophil [Ca 2+ ] i in the relatives of patients with Type 2 diabetes may similarly aid in determining whether the defect in SMCE predates development of disease.…”

Section: Discussionmentioning

confidence: 52%

“…Improvement in glycaemic control is associated with normalization of resting [Ca 2+ ] i [11]. Storemediated calcium entry is a cytoskeletal-dependent process and we have recently reported the same cytoskeletal defect in first-degree relatives of patients with Type 2 diabetes as that observed in the patients themselves [35]. In this study, subject groups differed in terms of BMI, blood pressure, lipids and insulin levels as well as level of glycaemia.…”

Section: Discussionmentioning

confidence: 56%

Impaired neutrophil store‐mediated calcium entry in Type 2 diabetes

Advani

Marshall

Thomas

2004

Eur J Clin Investigation

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“…Compared with healthy controls, serum levels of circulating ICAM-1 were also significantly increased in patients with recent-onset type 1 diabetes and their first-degree relatives. [ 105 , 106 ] Among these subjects, soluble ICAM-1 levels in prediabetic patients with positive autoantibodies were relatively higher than those in clinical diabetic patients and were positively correlated with levels of ICA and glutamic acid carboxylase autoantibodies. [ 58 ] This, together with the study on neutrophil infiltration of pancreatic islets mentioned above, suggests that the interaction between neutrophils and endothelial cells is definitely involved in the accumulation of inflammatory neutrophils in pancreatic islets and their destruction.…”

Section: Cell–cell Interactions In Type 1 Diabetesmentioning

confidence: 99%

Type 1 diabetes mellitus: Roles of neutrophils in the pathogenesis

Obeagu,

Obeagu

2023

Medicine

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Circulating neutrophil counts are reduced both in healthy autoantibody-positive individuals and in patients with type 1 diabetes, which may be related on cell-specific autoimmunity. This paper was written to give an update on roles of neutrophils in the pathogenesis of type 1 diabetes mellitus. Different research search engines like PubMed Central, Scopus, Web of Science, Researchgate, Google Scholar etc were utilised for writing this paper. A drop in blood neutrophil counts in type 1 diabetes may be caused by decreased neutrophil generation and maturation, tissue maintenance, consumption, or peripheral damage. Neutrophil count variations between studies may be explained by results from various stages of diabetes or by ethnic groups. Neutrophils can induce type 1 diabetes by colonizing pancreatic islets and interacting with other immune cells, according to exciting findings that shed new light on their role in the pathogenesis of the disease. Knowing more about the function of neutrophils in the pathogenesis of type 1 diabetes will help in early diagnosis, treatment, and even prevention of the disease.

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Neutrophil antigen exposure is altered with age in relatives of patients with Type 2 diabetes

Abstract: Abbreviations: BMI-SDS, body mass index standard deviation score · SDS, standard deviation score

Cited by 3 publications

References 9 publications

Neutrophils in type 1 diabetes

Neutrophils in type 1 diabetes

Impaired neutrophil store‐mediated calcium entry in Type 2 diabetes

Type 1 diabetes mellitus: Roles of neutrophils in the pathogenesis

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