Neutrophil attractant/activating peptide-1/interleukin-8: Association with histologic chorioamnionitis, preterm delivery, and bioactive amniotic fluid leukoattractants

Cherouny, Peter H.; Pankuch, Glenn A.; Romero, Roberto; Botti, John J.; Kuhn, Douglas C.; Demers, Laurence M.; Appelbaum, Peter C.

doi:10.1016/0002-9378(93)90297-v

Cited by 156 publications

(101 citation statements)

References 17 publications

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“…43 In relation to birth outcomes, elevated serum, intra-amniotic, and cervical IL-8 has been associated with preterm as well as term parturition. [44][45][46][47] IL-8, a chemokine, is a potent chemoattractant implicated in endothelial dysfunction. 48 As such, IL-8 plays an important role in the development of atherosclerosis and is implicated in risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

Blair

Porter

Leblebicioğlu

et al. 2015

Sleep

161

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1259Sleep and Preterm Birth-Blair et al. INTRODUCTIONIn the United States, preterm birth affects 11.5% of deliveries and is the underlying cause of more than one third of infant deaths.1 A high proportion of surviving preterm infants suffer from severe physical and cognitive consequences, potentially requiring intensive medical and/or educational support throughout the lifespan.2 The morbidity and mortality associated with preterm birth pose significant drains on the financial and emotional resources of afflicted families, and on the nation as a whole, costing more than $26 billion annually in the United States. 3Inflammation is a causal mechanism in the initiation of preterm as well as term labor. 4 Inflammatory mediators can initiate contractions, encourage cervical ripening, and cause rupture of the membranes.4,5 Via these mechanisms, inflammation induced by infection or psychological stress may trigger early parturition. 6,7Importantly, poor sleep promotes inflammation.8 For example, in a population-based cohort of more than 5,000 adults, shorter sleep duration was associated with elevations in Study Objectives: Poor sleep promotes inflammation. In turn, inflammation is a causal mechanism in term as well as preterm parturition. In the United States, a persistent racial disparity in preterm birth exists, with African Americans showing ~1.5 times greater risk. This study examined associations among sleep quality, serum proinflammatory cytokines, and length of gestation in a racially diverse sample of 138 pregnant women. Design: Observational. Measurements: Women completed the Pittsburgh Sleep Quality Index (PSQI) and other psychosocial and behavioral measures during midpregnancy. Serum levels of interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α were determined by high-sensitivity assays. Birth outcomes were determined via medical record review. Results: Among African American women (n = 79), shorter gestation was predicted by poorer overall sleep (r s = −0.35, P = 0.002) as well the following PSQI subscales: subjective sleep quality (r s = −0.34, P = 0.002), sleep latency (r s = −0.27, P = 0.02), and sleep efficiency (r s = −0.27, P = 0.02). African American women with poor sleep quality (PSQI > 5) had 10.2 times the odds of preterm birth compared to those with good sleep quality. In contrast, among European American women (n = 53), gestational length was not significantly predicted by sleep quality (Ps > 0.12). Bootstrapping analyses showed that, among African Americans, IL-8 significantly mediated the association between sleep quality and length of gestation (indirect effect estimate −0.029; 95% confidence interval −0.06, −0.002). Conclusions:The data provide novel evidence that African American women exhibit greater inflammation in response to sleep disturbance than European American women and these effects correspond with length of gestation. Racial differences in susceptibility to sleep induced immune dysregulation may contribute to marked racial disparities in preterm birth.

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Section: Discussionmentioning

confidence: 99%

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

Blair

Porter

Leblebicioğlu

et al. 2015

Sleep

161

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“…The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10 Introduction Pro-inflammatory cytokines, such as interleukin (IL)-1 [1][2][3][4][5][6][7][8], IL-6 [6][7][8][9][10][11][12], tumor necrosis factor (TNF) [5,6,[13][14][15][16][17][18], IL-18 [19], IL-16 [20], and chemokines such as IL-8 [7,8,[21][22][23], monocyte chemotactic protein-1 (MCP-1) [24,25], macrophage inflammatory protein-1 alpha (MIP-1a) [26], RANTES [27], and epithelial cell-derived neutrophil-activating peptide-78 [28], are involved in the mechanisms responsible for preterm labor (PTL). Indeed, strong evidence suggests that these cytokines are produced by gestational tissues in response to microbial products [1,[29][30][31][32][33], are present in high concentrations in the amniotic fluid of patients with intra-amniotic infection/inflammation (IAI) [1,3,6,<...>…”

mentioning

confidence: 99%

“…Indeed, strong evidence suggests that these cytokines are produced by gestational tissues in response to microbial products [1,[29][30][31][32][33], are present in high concentrations in the amniotic fluid of patients with intra-amniotic infection/inflammation (IAI) [1,3,6,[9][10][11]13,14,16,[19][20][21][22]24,26,27,[34][35][36][37][38], stimulate uterine contractility by inducing the production of prostaglandins [39][40][41][42][43][44][45][46][47][48][49][50], and can induce PTL and delivery [2,5,[51][52][53].…”

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confidence: 99%

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

Gotsch

Romero

Kusanovic

et al. 2008

The Journal of Maternal-Fetal & Neonatal Medicine

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122

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Objective. The anti-inflammatory limb of the immune response is crucial for dampening inflammation. Spontaneous parturition at term and preterm labor (PTL) are mediated by inflammation in the cervix, membranes, and myometrium. This study focuses on the changes in the amniotic fluid concentrations of the anti-inflammatory cytokine interleukin (IL)-10. The objectives of this study were to determine whether there is a relationship between amniotic fluid concentrations of IL-10 and gestational age, parturition (at term and preterm), and intra-amniotic infection/inflammation (IAI). Study design. A cross-sectional study was conducted including 301 pregnant women in the following groups: (1) midtrimester of pregnancy who delivered at term (n ¼ 112); (2) mid-trimester who delivered preterm neonates (n ¼ 30); (3) term not in labor without IAI (n ¼ 40); (4) term in labor without IAI (n ¼ 24); (5) term in labor with IAI (n ¼ 20); (6) PTL without IAI who delivered at term (n ¼ 31); (7) PTL without IAI who delivered preterm (n ¼ 30); (8) PTL with IAI who delivered preterm (n ¼ 14). IL-10 concentrations in amniotic fluid were determined by a specific and sensitive immunoassay. Nonparametric statistics were used for analysis. Results.(1) IL-10 was detectable in amniotic fluid and its median concentration did not change with gestational age from mid-trimester to term. (2) Patients in labor at term had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term not in labor (p ¼ 0.04). (3) Women at term in labor with IAI had a significantly higher median amniotic fluid IL-10 concentration than that of patients at term in labor without IAI (p ¼ 0.02). (4) Women with PTL and IAI who delivered preterm had a significantly higher median amniotic fluid concentration of IL-10 than those without IAI who delivered preterm and than those who delivered at term (p ¼ 0.009 and p 5 0.001, respectively). (5) Among patients with preterm labor without IAI, those who delivered preterm had a significantly higher median amniotic fluid IL-10 concentration than those who delivered at term (p ¼ 0.03). Conclusions. The anti-inflammatory cytokine IL-10 is detectable in the amniotic fluid of normal pregnant women. Spontaneous parturition at term and in preterm gestation is associated with increased amniotic fluid concentrations of IL-10. IAI (preterm and at term) is also associated with increased amniotic fluid concentrations of IL-10. We propose that IL-10 has a role in the regulation of the immune response in vivo by initiating actions that dampen inflammation.

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“…13 (bacterial culture). 6 Since steroid hormones such IL-6 was found in maternal and foetal serum as progesterone and corticosteroids are capable and the levels correlated strongly with the dura-of influencing IL-8 production, and prostation of labour, thus probably also with the extent glandins downregulate the threshold of PMN of cervical ripening and tissue destruction. 7 Since activation after IL-8 stimulation, 52 IL-8 might form the induction of IL-6 synthesis via mRNA takes the final common step of prostaglandin and several hours, the serum IL-6 peak found imme-steroid hormone action in parturition.…”

Section: Introductionmentioning

confidence: 99%

The contribution of the immune system to parturition

Jongh

Jorens

Student

et al. 1996

Mediators of Inflammation

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Neutrophil attractant/activating peptide-1/interleukin-8: Association with histologic chorioamnionitis, preterm delivery, and bioactive amniotic fluid leukoattractants

Cited by 156 publications

References 17 publications

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: A role for interleukin-10

The contribution of the immune system to parturition

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