Neutrophil-derived, oxygen free radical-mediated cardiovascular dysfunction*

Gt, Rowe; Lr, Eaton; Ml, Hess

doi:10.1016/s0022-2828(84)80020-6

Cited by 69 publications

(50 citation statements)

References 8 publications

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“…1,17 Increasing evidence supports the role of local and systemic oxidative stresses in the development and severity of myocarditis and cardiomyopathy. 8,18 Excessive production of reactive oxygen species (ROS) at the inflammatory site contributes to the inflammatory process by inducing the expression of adhesion molecules, proinflammatory cytokines, and chemoattractants. ROS scavengers, such as superoxide dismutase, have therapeutic potential for myocarditis.…”

Section: Discussionmentioning

confidence: 99%

Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin. A Case Report.

Shioji

Matsuura

Iwase

et al. 2002

Circ J

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Section: Discussionmentioning

confidence: 99%

Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin. A Case Report.

Shioji

Matsuura

Iwase

et al. 2002

Circ J

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“…and NO ⅐ in post-ischemic tissues and following the process of inflammation (9). It has also been shown that O 2 . plays a key role in NO ⅐ -induced toxicity, and previously proposed mechanisms for both O 2 .…”

mentioning

confidence: 99%

“…PMNs are chemotaxed and then activated at sites of tissue injury with the generation of oxygen free radicals and the release of proteolytic enzymes and other toxic products (2). Activated human PMNs generate superoxide (O 2 . )…”

mentioning

confidence: 99%

“…derived from PMNs or other sources to form the potent oxidant peroxynitrite (ONOO Ϫ ). However, questions remain regarding the effects of low physiological levels of NO ⅐ and how these or ONOO Ϫ modulate the NADPH oxidase function of and O 2 . generation from PMNs.…”

mentioning

confidence: 99%

“…These kinases are also modulated by various oxidants; and based on these interactions, it has been suggested that O 2 . or secondary oxidants are important mediators of cellular signaling.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Biphasic Regulation of Leukocyte Superoxide Generation by Nitric Oxide and Peroxynitrite

Lee¹,

Miura²,

Li³

et al. 2000

Journal of Biological Chemistry

119

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Reactive oxygen metabolites, antioxidants and head and neck cancer

1999

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This manuscript will review the probable role of reactive oxygen metabolites (ROM) in the etiopathogenesis of head and neck cancer (HNC). Cancer is a heterogeneous disorder with multiple etiologies including somatic and germ‐line mutations, cellular homeostatic disturbances, and environmental triggers. Certain etiologies are characteristic of HNC and include infectious agents such as the Epstein‐Barr virus, the use of tobacco, and consumption of alcohol. A large body of evidence implicates ROM in tumor formation and promotion. ROM species are formed in the process of cellular respiration, specifically during oxidative phosphorylation. These ubiquitous molecules are highly toxic in the cellular environment. Of the many effects of ROM, especially important are their effect on DNA. Specifically, ROM cause a variety of DNA damage, including insertions, point mutations, and deletions. Thus, it is hypothesized that ROM may be critically involved in the etiology of malignant disease through their possible impact on protooncogenes and tumor suppressor genes. Additionally, empirical evidence suggests that ROM may also affect the balance between apoptosis and cellular proliferation. If apoptotic mechanisms are overwhelmed, uncontrolled cellular proliferation may follow, potentially leading to tumor formation. Thus, this manuscript will critically review the evidence that supports the role of ROM in tumorigenesis. ROM scavengers and blockers have shown both in vivo and in vitro effects of attenuating the toxicity of ROM. Such compounds include the antioxidant vitamins (A, C, and E), nutrient trace elements (selenium), enzymes (superoxide dismutase, glutathione peroxidase, and catalase), hormones (melatonin), and a host of natural and synthetic compounds (lazaroids, allopurinol, gingko extract). Thus, this paper will also review the possible benefit derived from the use of such scavengers/blockers in the prevention of HNC. © 1999 John Wiley & Sons, Inc. Head Neck 21: 467–479, 1999.

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Neutrophil-derived, oxygen free radical-mediated cardiovascular dysfunction*

Cited by 69 publications

References 8 publications

Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin. A Case Report.

Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin. A Case Report.

Biphasic Regulation of Leukocyte Superoxide Generation by Nitric Oxide and Peroxynitrite

Reactive oxygen metabolites, antioxidants and head and neck cancer

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