Neutrophil extracellular traps in autoimmune diseases: Analysis of the knowledge map

Abstract

IntroductionRecent studies have shown much progress in the research of exosomes in AIDs. However, there is no bibliometric analysis in this research field. This study aimed to provide a bibliometrics review of the knowledge structure and research hotspots of neutrophil extracellular traps (NETs) in autoimmune diseases (AIDs).MethodsArticles relevant to NETs in AIDs from 2010 to 2022 were retrieved through the Web of Science Core Collection (WoSCC) database. This bibliometric analysis was performed by VOSview, CiteSpace, and Scimago Graphica.ResultsA total of 289 papers analyzed in this research were from 493 organizations in 47 countries by 1537 authors. They were published in 133 journals and cited 20,180 citations from 2,465 journals. The number of annual publications in this field is growing steadily and rapidly, with the United States, China and Germany leading the research effort. Frontiers in Immunology and Journal of Immunology have significantly impacted research in this field. Kaplan, Mariana J, from the National Institutes of Health (The United States), has the most published articles, and Brinkmann, v, from Max Planck Institute for Infection Biology (Germany), is the most co-cited author. Systemic lupus erythematosus and rheumatoid arthritis are the leading topics in this field. The trend of clinical application in the future is the development of new therapies by controlling NETs in the progression of AIDs.ConclusionsOur study summarized the research trends and developments of NETs in AIDs in recent years and would provide a reference for scholars in this field.

Mapping current status and emerging trends in NETosis: A bibliometric study

“…Mariana J. Kaplan from the National Institutes of Health in the United States and Brinkmann V from the Max Planck Institute for Infection Biology in Germany are the most prolific and co-cited authors, respectively, this finding is consistent with the bibliometric analysis on NETs in autoimmune diseases. [35] Mariana J. Kaplan focuses primarily on the role of NETosis in autoimmune diseases, Brinkmann V is mainly involved in basic research and mainly focuses on the mechanism of NETosis, where he and his colleagues first discovered that neutrophils can kill bacteria by releasing NETs . [33] There are mainly 5 academic teams, but unfortunately, they collaborate very little, which hinders academic development and innovation.…”

Neutrophil serine proteases

“…Furthermore, HNE processes the surface of toll-like receptors TLR2, TLR4, CD14, and tumor necrosis factor receptors. It can also degrade other neutrophil proteases and proteases inhibitors, resulting in both their activation and inactivation [17] .…”

“…The potent activity of NE is regulated by endogenous inhibitors, mainly by serpins such as α1-PI, α2-MG, α1-antitrypsin (α1-AT), SLPI, and elafin [15] . The uncontrolled outflow of HNE causes the degradation of extracellular matrix components and destroys alveolar epithelial cells, which may lead to the development of pulmonary disease [17] . Accumulations and excessive HNE activation in the lung are associated with the pathogenesis of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, or pneumococcal pneumonia.…”

“…Accumulations and excessive HNE activation in the lung are associated with the pathogenesis of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, or pneumococcal pneumonia. HNE is also involved in rheumatoid arthritis due to the degradation of the matrix and destruction of cartilage components [12,15,17,31] .…”

The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

“…В норме они формируют «первую» линию защиты организма против инфекций (бактерии, грибы, вирусы) путем фагоцитоза, дегрануляции, генерации ROS (reactive oxygen species), синтеза цитокинов и хемокинов. Среди механизмов, определяющих как «физиологическую», так и «патологическую» функции нейтрофилов, особое внимание привлечено к способности нейтрофилов формировать «сетевые» (web-like) структуры, получившие название «нейтрофильные внеклеточные ловушки» или NETs (neutrophil extracellular traps) [18,19]. Феномен NETs открыт менее 10 лет назад [20], рассматривается как важный механизм, обеспечивающий элиминацию инфекционных патогенов [21][22][23][24].…”