The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

Nasonov, E. L.; Avdeeva, A. S.; Reshetnyak, T. M.; Aleksankin, A. P.; Rubtsov, Yu. P.

doi:10.47360/1995-4484-2023-513-530

Naučno-praktičeskaâ revmatologiâ

2023

DOI: 10.47360/1995-4484-2023-513-530

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The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

E. L. Nasonov,

A. S. Avdeeva,

T. M. Reshetnyak

et al.

Abstract: Uncontrolled activation of neutrophils is considered an important mechanism of thromboinflammation and fibrosis in immunemediated rheumatic diseases (IMRD), malignant neoplasms, atherosclerosis, COVID-19 and many other acute and chronic inflammatory diseases of humans. Particular attention has been drawn to the ability of neutrophils to form “network” (web-like) structures, called “neutrophil extracellular traps” NETs. The process associated with the formation of NETs and the weakening of their degradation is … Show more

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2024

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Cited by 4 publications

References 261 publications

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The first clinical experience with selective DNA plasmasorption using the NucleoCapture Device in the treatment of systemic lupus erythematosus

Aseeva,

Pokrovsky,

Soloviev

et al. 2024

Sovremennaâ revmatologiâ

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology characterized by the overproduction of autoantibodies against various components of the nucleus of the patient's own cells with the development of immunoinflammatory tissue damage. In recent years, more and more data have accumulated on the involvement of neutrophils in the development of the clinical symptoms of SLE, and DNA-containing structures and neutrophil extracellular traps (NETs) playing an important role in this process. Effective neutralization of NETs in SLE can be achieved by removing circulating proteins and molecules associated with NETs from the bloodstream by selective plasma sorption of DNA using the NucleoCapture Device.This article describes the case of a patient who underwent three plasma sorption sessions aiming to suppress the activity of SLE. During the therapy, significant positive dynamics were achieved: the SLEDAI-2K index decreased from 32 to 12 points, the number of leukocytes in the blood normalized, renal function improved, and the immunological activity of the disease decreased.

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The first clinical experience with selective DNA plasmasorption using the NucleoCapture Device in the treatment of systemic lupus erythematosus

Aseeva,

Pokrovsky,

Soloviev

et al. 2024

Sovremennaâ revmatologiâ

Self Cite

View full text Add to dashboard Cite

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The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies

Vorkel,

Reshetnyak,

Lila

2024

Sovremennaâ revmatologiâ

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Vasculitis associated with antineutrophil cytoplasmic antibodies (AAV) is a potentially dangerous autoimmune disease characterized by necrotizing inflammation of small blood vessels. In the pathogenesis of AAV, both innate and adaptive immunity are closely linked to neutrophil function. The study of the pathogenetic mechanisms of neutrophil activation in AAV may serve as a prerequisite for the development of more accurate and modern methods of laboratory diagnostics as well as new treatment approaches targeting neutrophils. The review presents an analysis of studies addressing the issue of neutrophil activation in AAV.

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NETosis in lupus nephritis

Reshetnyak,

Nurbaeva,

Ptashnik

et al. 2024

Terapevticheskii arkhiv

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Aim. To evaluate the levels of MPO-DNA complex in patients with systemic lupus erythematosus (SLE) and its association with the presence of lupus nephritis (LN). Materials and methods. The study included 77 patients with SLE, of whom 30 had SLE without anti phospholipid syndrome (APS), 47 had SLE with APS, and 20 were healthy individuals serving as the control group. The MPO-DNA complex in the serum was investigated using ELISA. Results. The levels of MPO-DNA complex in serum were significantly higher in patients with SLE compared to healthy controls (p=0.001). Among the patients with SLE, 30 (39%) had elevated levels of MPO-DNA complex. The presence of elevated MPO-DNA complex was significantly associated with the presence of a history of LN (p=0.009). Moreover, among the patients included in the study, 20 had active LN, and patients with elevated MPO-DNA complex levels were more likely to have active LN than patients without elevated MPO-DNA complex concentrations [12 (40%) of 30 vs 8 (17%) of 47, χ2=5.029; p=0.034]. An association was found between elevated levels of MPO-DNA complex and the presence of proteinuria, hematuria, cellular hematic/granular casts and aseptic leukocyturia. A direct correlation of MPO-DNA complex with SLEDAI-R was found in patients with active LN (rs=0.497; p=0.026). Conclusion. Elevated levels of MPO-DNA complex were detected in 39% of patients with SLE. These patients had a higher prevalence of LN in their medical history and at the time of inclusion in the study. The correlation between MPO-DNA complex levels and the activity of LN according to SLEDAI-R indicates the potential role of MPO-DNA complex as a biomarker for assessing the activity of renal damage in SLE.

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The role of NETosis in the pathogenesis of immunoinflammatory rheumatic diseases

Cited by 4 publications

References 261 publications

The first clinical experience with selective DNA plasmasorption using the NucleoCapture Device in the treatment of systemic lupus erythematosus

The first clinical experience with selective DNA plasmasorption using the NucleoCapture Device in the treatment of systemic lupus erythematosus

The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies

NETosis in lupus nephritis

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