Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments

Chan, Lily; Morovati, Solmaz; Karimi, Negar; Alizadeh, Kasra; Vanderkamp, Sierra; Kakish, Julia E.; Bridle, Byram W.; Karimi, Khalil

doi:10.3390/cells11081322

Cited by 10 publications

(7 citation statements)

References 215 publications

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“…In both acute and chronic inflammation, the genetic structures of neutrophils appear to undergo a reprogramming process due to the stimulation of external signals, resulting in dynamic transitions between subpopulations. 132 , 133 , 134 In inflammatory diseases, infection or ischemia can induce the production of G‐CSF, GM‐CSF, or other myelopoietic factors, which contribute to different functional neutrophils. 135 , 136 , 137 We will discuss what factors would contribute to neutrophil heterogeneity in the context of diseases.…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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“…The microenvironment will influence the function and phenotype of these cells. Neutrophils can have positive and negative actions for the host, most likely depending on the stimuli that they receive [ 42 ]. Neutrophils are highly plastic cells that can polarize in response to different cues into different phenotypes.…”

Section: Neutrophils In Wound Healing Tissue Repair and Regenerationmentioning

confidence: 99%

The Role of Neutrophils in Biomaterial-Based Tissue Repair—Shifting Paradigms

Sousa

Barbosa

2023

JFB

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Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair and restore function of damaged tissues or organs. This can be achieved in different ways, either by promoting endogenous tissue repair or by using biomaterials or medical devices to replace damaged tissues. The understanding of the interactions of the immune system with biomaterials and how immune cells participate in the process of wound healing are critical for the development of successful solutions. Until recently, it was thought that neutrophils participate only in the initial steps of an acute inflammatory response with the role of eliminating pathogenic agents. However, the appreciation that upon activation the longevity of neutrophils is highly increased and the fact that neutrophils are highly plastic cells and can polarize into different phenotypes led to the discovery of new and important actions of neutrophils. In this review, we focus on the roles of neutrophils in the resolution of the inflammatory response, in biomaterial–tissue integration and in the subsequent tissue repair/regeneration. We also discuss the potential of neutrophils for biomaterial-based immunomodulation.

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“…However, there is growing evidence, that during viral infections, neutrophils may play both beneficial but also detrimental roles. 21 , 22 Firstly, neutrophils are recruited to sites of viral infections. Using imaging of the liver microcirculation, unveiled a significant recruitment of neutrophils following pox virus infection of liver cells.…”

Section: The Role Of Neutrophils In Viral Infectionsmentioning

confidence: 99%

“…Until recently, the neutrophil was not considered a major player in viral infections. However, there is growing evidence, that during viral infections, neutrophils may play both beneficial but also detrimental roles 21,22 . Firstly, neutrophils are recruited to sites of viral infections.…”

Section: The Role Of Neutrophils In Viral Infectionsmentioning

confidence: 99%

Neutrophils during SARS‐CoV‐2 infection: Friend or foe?

Castanheira

Kubes

2022

Immunological Reviews

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Summary Coronavirus disease 2019 (COVID‐19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has resulted in more than 6 million deaths worldwide. COVID‐19 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi‐organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID‐19. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID‐19 pathogenesis, and potential therapeutic strategies that target neutrophil‐mediated inflammatory responses.

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Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments

Cited by 10 publications

References 215 publications

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

The Role of Neutrophils in Biomaterial-Based Tissue Repair—Shifting Paradigms

Neutrophils during SARS‐CoV‐2 infection: Friend or foe?

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