Neutrophil Gelatinase-Associated Lipocalin in Cancer

Lippi, Giuseppe; Meschi, Tiziana; Nouvenne, Antonio; Mattiuzzi, Camilla; Borghi, Loris

doi:10.1016/b978-0-12-800263-6.00004-5

Cited by 57 publications

(54 citation statements)

References 100 publications

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“…by guest www.bloodjournal.org From a growing number of studies have provided evidence that a variety of solid tumors are characterized by overexpression of LCN2. [28][29][30][31] Previously, LCN2 has been implicated in the pathobiology of another MPN, chronic myeloid leukemia, where this iron-containing protein has been shown not only to promote BCR/ABL 1 hematopoiesis but also to inhibit the residual reservoir of normal hematopoietic progenitor cells, thereby likely contributing to the clonal dominance of the malignant clone. 14,18 Beyond its effects on tumor cells, LCN2 expression has also been implicated as a mediator of renal, pulmonary, and cardiac fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Lü

Xia

Liu

et al. 2015

Blood

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Key Points• LCN2 acts to generate reactive oxygen species, leading to increased DNA strand breaks and apoptosis in normal CD34 1 cells.• LCN2 promotes the generation of osteoblasts but diminishes adipogenesis, resembling the composition of the MF marrow microenvironment.Myelofibrosis (MF) is characterized by cytopenias, constitutional symptoms, splenomegaly, and marrow histopathological abnormalities (fibrosis, increased microvessel density, and osteosclerosis). The microenvironmental abnormalities are likely a consequence of the elaboration of a variety of inflammatory cytokines generated by malignant megakaryocytes and monocytes. We observed that levels of a specific inflammatory cytokine, lipocalin-2 (LCN2), were elevated in the plasmas of patients with myeloproliferative neoplasms (MF > polycythemia vera or essential thrombocythemia) and that LCN2 was elaborated by MF myeloid cells. LCN2 generates increased reactive oxygen species, leading to increased DNA strand breaks and apoptosis of normal, but not MF, CD34 1 cells. Furthermore, incubation of marrow adherent cells or mesenchymal stem cells with LCN2 increased the generation of osteoblasts and fibroblasts, but not adipocytes. LCN2 priming of mesenchymal stem cells resulted in the upregulation of RUNX2 gene as well as other genes that are capable of further affecting osteoblastogenesis, angiogenesis, and the deposition of matrix proteins. These data indicate that LCN2 is an additional MF inflammatory cytokine that likely contributes to the creation of a cascade of events that results in not only a predominance of the MF clone but also a dysfunctional microenvironment. (Blood. 2015;126(8):972-982)

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Section: Discussionmentioning

confidence: 99%

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Lü

Xia

Liu

et al. 2015

Blood

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“…11 Recently, lipocalin-2 was also noted to be associated with tumour invasiveness, possibly attributed to its ability to scavenge iron into cancer cells. 64 Resistin, another proinflammatory adipokine, was found to be present at higher levels in advanced nonsmall cell lung, colon, breast and prostate cancers. 11 A recent meta-analysis also suggested a consistent positive association between resistin and colorectal cancers, although the number of studies was limited.…”

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confidence: 99%

Obesity, adipokines and cancer: an update

Lee

Woo

Wang

et al. 2014

Clinical Endocrinology

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SummaryObesity causes dysfunction of adipose tissue, with resultant chronic inflammation and adverse interplay of various adipokines, sex steroids and endocrine hormones. All these drive tumourigenesis and explain the epidemiological link between obesity and cancer. Over the past decade, the associations among obesity, adipokines and cancer have been increasingly recognized. Adipokines and their respective signalling pathways have drawn much research attention in the field of oncology and cancer therapeutics. This review will discuss the recent advances in the understanding of the association of several adipokines with common obesity-related cancers and the clinical therapeutic implications.

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“…Increased serum NGAL concentrations have been accepted as a prognosis-related independent variable in different types of cancer. [13,16,17,[25][26][27][28] Although there are studies showing that increased serum NGAL levels indicate a relation with PCa diagnosis and poor prognosis, there is no study investigating possible role of NGAL in discrimination between benign, and malign diseases of the prostate. [29][30][31] In this study, potential role of NGAL in minimizing unnecessary biopsies as a biomarker was investigated and NGAL levels were found to be significant higher than PSA in PCa patients relative to BPH patients.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have argued that NGAL and matrix metalloproteinases (MMP) are involved in extracellular matrix degradation by forming a complex, and NGAL can play an important role in the development, progress, and invasion of cancer. [13][14][15][16][17] The aim of this study is to test serum NGAL levels as a biomarker for distinguishing PCa from BPH. To achieve this goal serum NGAL levels with and without serum PSA levels were compared with serum PSA levels alone in terms of their specificity, sensitivity and area under curve (AUC) values.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

Muşlu

Ercan

Akbayir³

et al. 2017

Turkish Journal of Urology

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Objective: Prostate specific antigen (PSA) with digital rectal examination is used for diagnosis of prostate cancer (PCa), where definite diagnosis can only be made by prostate biopsy. Recently neutrophil gelatinaseassociated lipocalin (NGAL), a lipocalin family member glycoprotein, come into prominence as a cancer biomarker. This study is aimed to test serum NGAL as a diagnostic biomarker for PCa and discriminate PCa from benign prostatic hyperplasia (BPH). Material and methods:In this prospective study, 90 patients who underwent transrectal ultrasound-guided 12-core prostate biopsy between May 2015 and September 2015, were evaluated. Histopathologically diagnosed 45 PCa and 45 BPH patients were enrolled in this study. Serum NGAL and PSA levels of all participants were measured, then these data were evaluated by statistical programs. Results: When sensitivity fixed to 80% specificity of NGAL was better than PSA (49%, 31% respectively). Receiver operating characteristic (ROC) curve analysis showed that NGAL alone or its combined use with PSA have better area under curve (AUC) results than PSA alone (0.662, 0.693, and 0.623 respectively). Conclusion: In conclusion NGAL gave promising results such as increased sensitivity and a better AUC values in order to distinguish PCa from BPH. NGAL showed a potential to be a non-invasive biomarker which may decrease the number of unnecessary biopsies.

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Neutrophil Gelatinase-Associated Lipocalin in Cancer

Cited by 57 publications

References 100 publications

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Obesity, adipokines and cancer: an update

Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

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