Neutrophil, Lymphocyte, and Platelet Counts and Acute Kidney Injury After Cardiovascular Surgery

Koo, Chang Hoon; Jung, Da Eun; Park, Yoon Sang; Bae, Jaeman; Cho, Youn Joung; Kim, Won Ho; Bahk, Jae Hyon

doi:10.1053/j.jvca.2017.08.033

Cited by 56 publications

(68 citation statements)

References 43 publications

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“…[ 21 ] Their data also reports an association between the N/LP ratio and short and long-term mortality. [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 13 , 18 – 20 ] In order to combine the predictive ability of the N/L ratio and platelet count, Koo et al developed the N/LP ratio in the setting of postoperative AKI after cardiovascular surgery. [ 21 ] In a multivariate analysis, the ratio was independently associated with AKI differently than separate N/L ratio and platelet nadir. [ 21 ] Their data also reports an association between the N/LP ratio and short and long-term mortality.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] In a multivariate analysis, the ratio was independently associated with AKI differently than separate N/L ratio and platelet nadir. [ 21 ] Their data also reports an association between the N/LP ratio and short and long-term mortality. [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…In cardiovascular surgery it was also associated with one-year mortality [ 20 ]. More recently, the addition of platelet count to this ratio increased predictive ability of AKI compared to N/L ratio or platelet nadir after cardiovascular surgery [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

et al. 2018

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BackgroundSurgery is one of the leading causes of acute kidney injury (AKI) in hospitalized patients. Major abdominal surgery has the second higher incidences of AKI, after cardiac surgery. AKI results from a complex interaction between hemodynamic, toxic and inflammatory factors. The pathogenesis of AKI following major abdominal surgery is distinct from cardiac and vascular surgery. The neutrophil, lymphocytes and platelets (N/LP) ratio has been demonstrated as an inflammatory marker and an independent predictor for AKI and mortality after cardiovascular surgery. The aim of this study was to evaluate the prognostic ability of the post-operative N/LP ratio after major abdominal surgery.MethodsWe cross-examined data of a retrospective analysis of 450 patients who underwent elective or urgent major nonvascular abdominal surgery at the Department of Surgery II of Centro Hospitalar Lisboa Norte from January 2010 to February 2011. N/LP ratio was determined using maximal neutrophil counts and minimal lymphocyte and platelet counts in the first 12 h after surgery. AKI was considered when developed within 48 h after surgery.ResultsOne-hundred and one patients (22.4%) developed AKI. Patients with higher N/LP ratio had an increased risk of developing postoperative AKI (6.36 ± 7.34 vs 4.33 ± 3.36, p < 0.001; unadjusted OR 1.1 (95% CI 1.04–1.16), p = 0.001; adjusted OR 1.05 (95% CI 1.00–1.10), p = 0.048). Twenty-nine patients died (6.44%). AKI was an independent predictor of mortality (20.8 vs 2.3%, p < 0.0001; unadjusted OR 11.2, 95% CI 4. 8-26.2, p < 0.0001; adjusted OR 3.56, 95% CI 1.0 2-12.43, p = 0.046). In a multivariate analysis higher N/LP ratio was not associated with increased in-hospital mortality.ConclusionPostoperative N/LP ratio was independently associated with AKI after major abdominal surgery, although there was no association with in-hospital mortality.

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“…[ 21 ] Their data also reports an association between the N/LP ratio and short and long-term mortality. [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

et al. 2018

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“…In this respect, the study by Koo et al in this issue of the journal might be of special interest. 13 The authors showed in an elegant statistical approach that the perioperative high neutrophil/(lymphocyte Â platelet) ratio (N/LP) is independently associated with increased risk of postoperative AKI and 5-year mortality. These blood cell counts are simple laboratory parameters, which are available in routine clinical practice.…”

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confidence: 99%

Avoiding Acute Kidney Injury After Cardiac Surgery: Simple and Easy?

Bolliger

Fassl

2018

Journal of Cardiothoracic and Vascular Anesthesia

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The predictive value of RDW in AKI and mortality in patients with traumatic brain injury

Wang

et al. 2020

Clinical Laboratory Analysis

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Background Red blood cell distribution width (RDW) has been validated valuable in predicting outcome and acute kidney injury (AKI) in several clinical settings. The aim of this study was to explore whether RDW is associated with outcome and AKI in patients with traumatic brain injury (TBI). Methods Patients admitted to our hospital for TBI from January 2015 to August 2018 were included in this study. Multivariate logistic regression analysis was performed to identify risk factors of AKI and outcome in patients with TBI. The value of RDW in predicting AKI and outcome was evaluated by receiver operating characteristic (ROC) curve. Results Three hundred and eighteen patients were included in this study. The median of RDW was 14.25%. We divided subjects into two groups based on the median and compared difference of variables between two groups. The incidence of AKI and mortality was higher in high RDW (RDW > 14.25) group (31.45% vs 9.43%, P < .001; 69.81% vs 29.56%, P < .001). Spearman's method showed RDW was moderately associated with 90‐day Glasgow Outcome Scale (GOS) (P < .001). In multivariate logistic regression analysis, RDW, lymphocyte, chlorine, and serum creatinine were risk factors of AKI. And Glasgow Coma Scale (GCS), glucose, chlorine, AKI, and RDW were risk factors of mortality. The area under the ROC curve (AUC) of RDW for predicting AKI and mortality was 0.724 (0.662‐0.786) and 0.754 (0.701‐0.807), respectively. Patients with higher RDW were likely to have shorter median survival time (58 vs 70, P < .001). Conclusions Red blood cell distribution width is an independent risk factor of AKI and mortality in patients with TBI.

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Neutrophil, Lymphocyte, and Platelet Counts and Acute Kidney Injury After Cardiovascular Surgery

Cited by 56 publications

References 43 publications

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

Avoiding Acute Kidney Injury After Cardiac Surgery: Simple and Easy?

The predictive value of RDW in AKI and mortality in patients with traumatic brain injury

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