Neutrophil-lymphocyte and platelet-lymphocyte ratios as inflammation markers for bipolar disorder

Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?

“…17,18 Considering that these markers are derived from routine complete blood count (CBC), it is also easy and replicable. Many studies investigated NLR and PLR in adult individuals with various neuropsychiatric disorders such as Alzheimer disease, 19 schizophrenia, 20 bipolar disorders, 21 depression 22 and mainly NLR has found to be increased in these studies. In literature there is only one study focused on NLR in ASD.…”

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

“…However, it is not clear in which phase the patients are in this study [32]. In the other study, it was reported that manic and euthymic male patients had higher NLR and PLR compared to controls [31]. The results of the current study in terms of NLR are consistent with the study of Kalelioglu et al, however, the differences in PLR between the study reported by Kalelioglu et al and the current study may be due to methodological variations including composition of the study samples (male vs. female), study sizes, medications, heterogeneous body mass index, and smoking status of participants.…”

“…(3) There was no difference among the patient groups (manic, depressed, and euthymic) in terms of NLR and PLR. NLR has been reported in recent years as a peripheral inflammation marker in several neuropsychiatric disorders [29][30][31][32]36]. NLR was reported to be significantly higher in Alzheimer's disease and schizophrenia when compared to controls [29,30].…”

“…Studies in which inflammatory mechanisms play a role in the aetiology of BD are becoming increasingly important. According to our knowledge, three studies have investigated the association between NLR or PLR and BD to date [31][32][33]. However, the results of these studies vary according to different episodes of BD.…”

“…There have also been studies investigated NLR and PLR in BD. In a study, manic and euthymic patients with BD showed an increase in NLR and PLR compared to controls [31]. In another study, patients with BD demonstrated increased NLR compared to controls [32].…”