Neutrophil-lymphocyte and platelet-lymphocyte ratios in rheumatoid arthritis patients: Relation to disease activity

Meta‐analysis of neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio in rheumatoid arthritis

“…After a full‐text revision of 25 articles, 12 studies were excluded because they did not meet the inclusion criteria. Thus, thirteen studies were included in the meta‐analysis . The characteristics of these studies, published between 2015 and 2017, are presented in Table .…”

“…Eight studies evaluated PLR in a total of 380 RA patients (203 males and 177 females) and 305 healthy controls (149 males and 156 females). The mean ± SD age of RA patients and controls was 39.7 ± 6.8 and 37.3 ± 5.8 years, respectively.…”

“…This issue needs to be addressed in future studies evaluating haematological parameters in RA given the known influence of several immunomodulating drugs on circulating blood cells. Thirdly, the role of NLR and PLR as markers of RA disease severity (measured by Disease Activity Score‐28 joints, DAS‐28) was not investigated due to the relatively low number of relevant studies and the high heterogeneity in cut‐offs used . Lastly, the assessment of NLR and PLR according to RF and ACPA positivity was not performed for similar reasons …”

“…Thus, thirteen studies were included in the meta-analysis. [6][7][8][9][10][11][12][13][14][15][16][17]33 The characteristics of these studies, published between 2015 and 2017, are presented in Table 1.…”

“…Recently, several reports have suggested the potential utility of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR), as diagnostic biomarkers in RA [6][7][8][9][10][11][12][13][14][15][16][17] and other rheumatic diseases. [18][19][20] A previous meta-analysis reported a significant association between NLR and PLR and RA.…”