Neutrophil-Lymphocyte Ratio and the Platelet Parameters as Biomarkers of Atopic Dermatitis Severity in Children

Gayret, Özlem Bostan; Nacaroğlu, Hikmet Tekin; Erol, Meltem; Şener, Ahmet

doi:10.5812/ircmj.91594

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…A study (14.0±13.2 months-aged children) reported that MPV was higher in the severe-AD group, and PDW was lower in the mild-AD group. 19 A study (60.01±46.45 months) reported a correlation between NLR and SCORAD.6 However, we could not find evidence for a hemogram parameter correlating with disease duration in our under-4-year-old patient group. RDW had anecdotal evidence for correlating with disease duration.…”

Section: Discussioncontrasting

confidence: 60%

“…Similar to this result, a study reported that they did not find a correlation with AD regarding WBC, MCV, or RDW values; however, they reported increased MPV and decreased PDW in the AD group. 18 Another study (aged 14.03±13.17 months patient group) did not find significant differences regarding MPV, NLR, or PLR, but they reported decreased PDW in the AD group, 19 and increased E% and decreased PDW were the significant confounder factors. 19 In another study (6.4+/-3.5 months), MPV and PLT were lower in the AD group, where WBC, NC, LC, EC, NLR, PLR, ELR, and RDW were not statistically different.…”

Section: Discussionmentioning

confidence: 93%

“…18 Another study (aged 14.03±13.17 months patient group) did not find significant differences regarding MPV, NLR, or PLR, but they reported decreased PDW in the AD group, 19 and increased E% and decreased PDW were the significant confounder factors. 19 In another study (6.4+/-3.5 months), MPV and PLT were lower in the AD group, where WBC, NC, LC, EC, NLR, PLR, ELR, and RDW were not statistically different. 20 In the older-4 years group, EC remained the only factor to differentiate AD from the control group with anecdotal evidence, and other parameters had moderate and anecdotal evidence for the independence hypothesis in our study group.…”

Section: Discussionmentioning

confidence: 93%

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The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

ÇİÇEK,

KANDEMİR,

KÖLE

2023

J Health Sci Med / JHSM

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Aims: We aimed to assess the association of hemogram parameters with atopic dermatitis (AD), severity of AD, and disease duration. Methods: We included the hemogram parameters of patients under follow-up in our pediatric allergy outpatient clinic and healthy group. The blood samples were drawn when they had no complaints or after at least 30 days of infection or a drug-free period. We built H1 and H0 (null) hypotheses, subjected data to Bayesian statistics, and assessed which hemogram parameters have potential and which shall not be used, with presenting evidence levels. We split the transactions into two groups (

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

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The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

ÇİÇEK,

KANDEMİR,

KÖLE

2023

J Health Sci Med / JHSM

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“…However, there was no difference between control and study groups in terms of PLR values. In the study presented by Gayret et al, 13 there was no statistically significant difference and no statistically significant correlation between disease severity and PLR values. Considering the data of our study, there was no significant increase in PLR levels in the patient group diagnosed with AD.…”

Section: Discussionmentioning

confidence: 73%

“…However, NLR was significantly higher in severe AD patients than in mild AD patients. 7 In the study performed by Gayret et al, 13 no significant difference was observed between AD patients and controls for NLR values. In the present study, although the NLR was found to be statistically significant for the AD patient group compared with the control group, there was no difference between the groups in the disease severity classification made with the SCORAD index.…”

Section: Discussionmentioning

confidence: 87%

Assessment of Venous Blood Leukocyte Profiles and Immunoglobulin E Levels in Atopic Dermatitis Patients

Kara

Solak

2022

Dermatitis

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BackgroundThere are differing results in the literature regarding the relationship between atopic dermatitis (AD) and peripheral blood leukocyte profiles.ObjectiveThe aim of the study was to investigate the relationship between AD, blood immune cell profiles, and disease severity.MethodsOne hundred AD patients aged 1 month to 18 years without any history of infection or systemic disease were enrolled as the study group. Serum concentration levels of total immunoglobulin E, calculated blood leukocyte profiles, and AD index severity scoring were calculated for statistical comparison.ResultsThe differences between the groups for neutrophil-lymphocyte ratio and eosinophil-lymphocyte ratio were statistically different. However, there was no statistically significant correlation between the investigated parameters and AD index severity scoring.ConclusionsAlthough significant differences were found in some of the parameters between the groups, unfortunately, the lack of correlation between the parameters investigated and the disease severity index restricts their use in clinical practice.

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Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

Koval,

Bondarovych,

Goltsev

2023

Innov Biosyst Bioeng

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Background. Atopic dermatitis (AD) is an inflammatory skin disease caused by a shift in the interaction between cells of the immune system and the skin. Steroid anti-inflammatory drugs used to treat AD often lead to numerous side effects. Therefore, the development of new natural multifunctional preparations with immunomodulatory activity is of great importance. Objective. To determine the changes in indices of the leukocytes cluster of peripheral blood and determine the peculiarities of cytomorphological changes in the spleen and lymph nodes (LN) of rats with induced AD before and after administration of cryopreserved (cHCBL) and lyophilized (lHCBL) forms of human cord blood leukoconcentrate. Methods. The experiments were conducted using 6-month-old Wistar rats. AD was induced by topically applying a 5% alcohol-acetone solution of dinitrochlorobenzene (DNCB) to the skin of the rats' back for 21 days. Each form of the preparation (cHCBL and lHCBL) was administered intraperitoneally in a 0.5 ml dose containing 5´106 cells, one day after the final DNCB treatment. The following parameters were assessed in the blood: leukocyte count and the neutrophil-to-lymphocyte ratio (N/L index). Сytomorphological characteristics were determined in the spleen and inguinal LN. Results. In AD, specific changes in the cytomorphological characteristics of the lymphohematopoietic complex (LHС) structures, namely the spleen and LN, were observed alongside alterations in the leukocyte cluster indices. The most notable changes in the spleen included the dominance of the white pulp over the red pulp and the prevalence of follicles of stages II and III of development in the LN. Animals with AD displayed pronounced leukocytosis and an increased N/L index in their blood. The study demonstrates the positive corrective effects of cHCBL and lHCBL on the morphological characteristics of LHC and the specified blood parameters. Conclusions. The effectiveness of the cHCBL and lHCBL use for correcting indices of leukocytes cluster of peripheral blood and the structural organization of lymphohemopoietic organs in the development of AD have been proven.

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Neutrophil-Lymphocyte Ratio and the Platelet Parameters as Biomarkers of Atopic Dermatitis Severity in Children

Cited by 4 publications

References 34 publications

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

Assessment of Venous Blood Leukocyte Profiles and Immunoglobulin E Levels in Atopic Dermatitis Patients

Cord Blood as a Corrector of Hematological and Cytomorphological Characteristics of Lymphohemopoietic Organs in Experimental Atopic Dermatitis

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