Neutrophil-to-Lymphocyte Ratio: A Comparative Study of Rupture to Nonruptured Infrarenal Abdominal Aortic Aneurysm

Aurelian, Sasarman Vasile; Molnar, AA; Andercou, Octavian; Bruno, Schjoth; Oprea, Alexandru; Catalin, Trifan; Dan, Bernard

doi:10.1016/j.avsg.2018.11.026

Cited by 23 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1. After reviewing the full-text articles, the remaining 14 observational studies were included in current meta-analysis [13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: General Characteristic Of Studies Included In the Metaanalysismentioning

confidence: 99%

“…Seven studies also investigated the prognostic value of high NLR for mortality in aortic disease, the outcome was mortality [14,[21][22][23][24][25][26]. One thousand one hundred thirty-nine aortic disease patients in the high NLR group, and 1824 aortic disease patients in the low NLR group were included in meta-analysis (Fig.…”

Section: Prognostic Value Of High Nlr For Mortality In Aortic Diseasementioning

confidence: 99%

“…Recently, the relationship between NLR and aortic disease has been investigated by several studies [11,12]. Authors focus on the NLR level in aortic aneurysm and aortic dissection patients, and the predictive value of high NLR in mortality and other clinical outcomes [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Therefore, the current meta-analysis was performed to clarify the relationship between NLR and aortic disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies

Fang

Qiu

et al. 2020

J Cardiothorac Surg

View full text Add to dashboard Cite

Objective: Recent studies have reported that neutrophil-to-lymphocyte ratio (NLR) is associated with cardiovascular disease. The aim of the present study was to investigate the prognostic value of NLR in aortic disease. Methods: We systematically searched electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase) from their inception to March 2020. Observational studies that evaluated the relationship between NLR and aortic disease were eligible for critical appraisal. Data were extracted from applicable articles, risk ratio (RR), weighted mean differences (MD) and 95% confidence intervals (CI) were calculated by RevMan 5.3, and statistical heterogeneity was assessed by the I 2 statistic. Results: Fourteen studies enrolling 4066 individuals were included in the meta-analysis. Compared with the control group, NLR was significantly higher in the aortic disease group (MD 3.44, 95%CI: 0.81-6.07, P = 0.01, I 2 = 99%). The NLR was also significantly higher in non-survivors with aortic disease, compared to the survivors (MD 4.62, 95%CI: 2.75-6.50, P < 0.00001, I 2 = 60%). Compared with the aortic disease patients with a low NLR, mortality was significantly higher in those with a high NLR (RR 2.63, 95%CI: 1.79-3.86, P < 0.00001, I 2 = 67%). Conclusion: Based on current evidence, an elevated NLR was associated with aortic disease and in-hospital mortality. Raised NLR also demonstrated a significantly increased the risk of mortality after surgical repair in aortic disease patients. NLR may be a good prognostic biomarker in aortic disease and deserve further research in this area.

show abstract

“…1. After reviewing the full-text articles, the remaining 14 observational studies were included in current meta-analysis [13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: General Characteristic Of Studies Included In the Metaanalysismentioning

confidence: 99%

Section: Prognostic Value Of High Nlr For Mortality In Aortic Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies

Fang

Qiu

et al. 2020

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…Particularly, NLR is unlikely to be affected by various physiological conditions such as dehydration and exercise, despite these conditions may affect the absolute number of the individual cell type [15]. Second, and most prominently, NLR is the ratio of two different types of immune cells which serve in complementary immune pathways [16]. The neutrophil count reflects ongoing inflammation, whereas the lymphocyte count reflects the regulatory immune pathway [17].…”

Section: Introductionmentioning

confidence: 99%

“…Besides, these studies, as mentioned earlier, mainly investigated the relationship between NLR and the occurrence of HT in patients receiving thrombolytic therapy [16]. Although thrombolytic therapy such as recombinant tissue plasminogen activator rtPA is considered the first-line approach for the management of AIS, it is undoubtedly a risk factor for HT.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte Ratio as a Risk Determinant of Hemorrhage Transformation in Acute Ischemic Stroke

Bilal

Shu

et al. 2020

JMN

View full text Add to dashboard Cite

Objective: The purpose of this study was to investigate the clinical significance between neutrophil-to-lymphocyte ratio (NLR) and classification of non-thrombolytic hemorrhagic transformation (HT) in acute ischemic stroke (AIS), to unravel new diagnostic approach. Methods: We recruited and selected 636 patients who did not undergo thrombolytic therapy between May 2018 and April 2019 at the Affiliated Hospital of Xuzhou Medical University. The laboratory and clinical data were collected within 24 h after the onset of AIS. Based on the status of HT development during hospitalization, all participants were divided into three groups, namely, the non-HT (NHT) group, hemorrhagic infarction (HI) group, and parenchymal hematoma (PH) group. Results: Multivariate logistic regression analysis showed that NLR and the ischemic lesion diameter are independent risk factors of HI and PH, while the score of National Institutes of Health Stroke Scale (NIHSS) and cardioembolism are considered to be independent risk factors for PH only. Receiver operating characteristic (ROC) analysis determined that the optimal cutoff values of NLR in HI group and PH group were 3.75 and 3.97, respectively. The optimal cutoff value can be used as the critical value for the unfavorable outcome. Conclusion: NLR values were significantly increased and correlated with both HI and PH groups and NLR could be used as a predictor of both HI and PH.

show abstract

Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury

Huanggu

Yang

Zheng

2023

Autoimmunity Reviews

View full text Add to dashboard Cite

Neutrophil-to-Lymphocyte Ratio: A Comparative Study of Rupture to Nonruptured Infrarenal Abdominal Aortic Aneurysm

Cited by 23 publications

References 27 publications

Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies

Prognostic role of neutrophil-to-lymphocyte ratio in aortic disease: a meta-analysis of observational studies

Neutrophil-to-lymphocyte Ratio as a Risk Determinant of Hemorrhage Transformation in Acute Ischemic Stroke

Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury

Contact Info

Product

Resources

About