Neutrophil-to-lymphocyte ratio for early renal failure under extracorporeal membrane oxygenation support for postcardiotomy shock

Sarğın, Murat; Erdoğan, Sevinç Bayer; Kuplay, Hüseyin; Baştopçu, Murat; Bayraktar, Fatih Avni; Acarel, Murat; Aka, Serap Aykut

doi:10.5606/tgkdc.dergisi.2019.17891

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…In addition, we also found that kidney function is the worst in the third tertile group, which may be an important impact factor of outcomes. A previous study (24) showed that NLR was significantly increased in patients with renal failure, which was in line with our results. Importantly, when we adjusted the Cr variable, the dNLR remains a significant predictive power of mortality.…”

Section: Discussionsupporting

confidence: 94%

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

Gang-qiong

Zhang

Shangguan

et al. 2021

Front. Cardiovasc. Med.

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Aims: The present study aimed to investigate the prognostic role of derived neutrophil-to-lymphocyte ratio (dNLR) in patients with coronary heart disease (CHD) after PCI.Methods: A total of 3,561 post-PCI patients with CHD were retrospectively enrolled in the CORFCHD-ZZ study from January 2013 to December 2017. The patients (3,462) were divided into three groups according to dNLR tertiles: the first tertile (dNLR < 1.36; n = 1,139), second tertile (1.36 ≥ dNLR < 1.96; n = 1,166), and third tertile(dNLR ≥ 1.96; n = 1,157). The mean follow-up time was 37.59 ± 22.24 months. The primary endpoint was defined as mortality (including all-cause death and cardiac death), and the secondary endpoint was major adverse cardiovascular events (MACEs) and major adverse cardiovascular and cerebrovascular events (MACCEs).Results: There were 2,644 patients with acute coronary syndrome (ACS) and 838 patients with chronic coronary syndrome (CCS) in the present study. In the total population, the all-cause mortality (ACM) and cardiac mortality (CM) incidence was significantly higher in the third tertile than in the first tertile [hazard risk (HR) = 1.8 (95% CI: 1.2–2.8), p = 0.006 and HR = 2.1 (95% CI: 1.23–3.8), p = 0.009, respectively]. Multivariate Cox regression analyses suggested that compared with the patients in the first tertile than those in the third tertile, the risk of ACM was increased 1.763 times (HR = 1.763, 95% CI: 1.133–2.743, p = 0.012), and the risk of CM was increased 1.763 times (HR = 1.961, 95% CI: 1.083–3.550, p = 0.026) in the higher dNLR group during the long-term follow-up. In both ACS patients and CCS patients, there were significant differences among the three groups in the incidence of ACM in univariate analysis. We also found that the incidence of CM was significantly different among the three groups in CCS patients in both univariate analysis (HR = 3.541, 95% CI: 1.154–10.863, p = 0.027) and multivariate analysis (HR = 3.136, 95% CI: 1.015–9.690, p = 0.047).Conclusion: The present study suggested that dNLR is an independent and novel predictor of mortality in CHD patients who underwent PCI.

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Section: Discussionsupporting

confidence: 94%

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

Gang-qiong

Zhang

Shangguan

et al. 2021

Front. Cardiovasc. Med.

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“…When our findings were examined, it was found that pseudoaneurysms were compatible within the literature in terms of the risk of development by hypertension, chronic kidney disease and the inappropriate area of intervention (1,2,6). When we examine the literature (11)(12)(13)(14), we see that there are studies on new markers aimed at supporting diagnosis in anticipating the follow-up, treatment and complications of peripheral vascular, aorta and cardiac diseases. In particular, the number and ratio of various cell elements in CBC are used for this purpose.…”

Section: Discussionmentioning

confidence: 99%

“…In these studies, it is aimed to predict complications based on the proportions of blood elements and to use them as a marker in diagnosis. These include NLR, LPR and NPR (11)(12)(13). In addition to these rates, PPR, which has not been studied before in the literature, has been examined in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, there is still no diagnostic test to predict which patient may develop a pseudoaneurysm. In the literature, studies are carried out on platelet to lymphocyte, neutrophil to lymphocyte, platelet to neutrophil ratios based on Complete Blood Count (CBC) for use to predicting cardiovascular pathology with inflammation parameters (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Blood Biochemistry and Hematological Parameters on the Development of Pseudoaneurysm

Tunçay¹,

Özmen²,

Elçik³

et al. 2020

Kocatepe Tıp Dergisi

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Koroner arter hastalığı halen önde gelen sağlık sorunlarından biridir. Bu durum, kalp hastalıkları için tanı ve tedavi prosedürlerinde artışa sebep olmaktadır. Bununla birlikte, bu prosedürlerle ilişkili komplikasyonlarda da artışa sebep olmaktadır. Bu komplikasyonlardan biri psödoanevrizmalardır. Bu çalışmada, kliniğimizde psödoanevrizma ameliyatı geçiren hastalarda koroner anjiyografiden önce alınan periferik tam kan sayımlarının sonuçlarına göre psödoanevrizmanın gelişimini öngörmede hematolojik ve biyokimyasal parametrelerin yararlı olup olmayacağını tartışmayı amaçladık. GEREÇ VE YÖNTEM: Ocak 2017-Aralık 2019 tarihleri arasında hastanemizde koroner arter hastalığı ön tanısı ile elektif koroner anjiyografi yapılan 7368 hastanın verileri retrospektif olarak incelendi. Çalışmamıza dahil edilme kriterlerini karşılayan 88 hastanın verileri incelendi. BULGULAR: Psödoanevrizma erkek cinsiyet(%60), sağ alt ekstremite(%76.4) ve ana femoral arterde(%71.4) daha sıktı. Grup 1 ile karşılaştırıldığında psödoanevrizma gelişen Grup 2'de işlemden önce beyaz küre sayısı (WBC) (p: 0.042) ve Nötrofil lenfosit oranı (NLR) (p: 0.029) değerleri ve kan üre azotu (BUN) (p:0.050) yüksekti, Hemoglobin (Hb) (p<0.001), hematokrit htc(p<0.001), albumin(p: 0.026) değerleri düşüktü ve istatistiksel olarak anlamlı fark vardı. Platelet Pletekrit Oranı (PPR) (p: 0.205), Platelet Nötrofil Oranı (PNR)(p: 0.205), platelet(p: 0.103), total protein(p: 0.061), kreatin (p:0.060) ve Platekrit(p: 0.151) değerleri arasında istatistiksel olarak anlamlı bir fark yoktu.

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“…As a result of this response, the NLR is positively affected, which may induce undesired results in the postoperative period. [ 2 , 3 ] Platelets are important mediators of inflammatory and ischemic damage in vital organs. It has been shown that low platelet count after CABG is associated with early mortality and poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

The effect of the relationship between post-cardiotomy neutrophil/lymphocyte ratio and platelet counts on early major adverse events after isolated coronary artery bypass grafting

Abanoz

Engin

2021

Turk Gogus Kalp Dama

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Background In this study, we aimed to investigate the role of postcardiotomy neutrophil, lymphocyte, and platelet counts in predicting major adverse events after coronary artery bypass grafting. Methods A total of 373 patients (257 males, 116 females; median age 63, range 33 to 85 years) who underwent isolated coronary artery bypass grafting under cardiopulmonary bypass between January 2015 and January 2020 were retrospectively analyzed. The patients who did not develop any postoperative major adverse event were included in Group 1, while those who did constituted Group 2. Preoperative neutrophil-to-lymphocyte ratio, postcardiotomy neutrophil-to-lymphocyte ratio, postoperative Day 1 neutrophil-to-lymphocyte ratio, and neutrophil-to-lymphocyte x platelet ratio were calculated. Results Preoperative neutrophil counts, C-reactive protein values, neutrophilto- lymphocyte ratio, total perfusion time, and length of intensive care unit and hospital stay were significantly higher in Group 2 (p=0.019, p=0.028, p<0.001, p=0.027, p<0.001, and p<0.001, respectively). Post-cardiotomy neutrophil, neutrophil-to-lymphocyte ratio, and neutrophil-to-lymphocyte x platelet ratio, along with the postoperative first day white blood cell count, neutrophil, C-reactive protein, neutrophil-to-lymphocyte ratio, and neutrophil-to-lymphocyte x platelet ratio were significantly higher in Group 2 (p=0.004, p<0.001, p<0.001, p=0.019, p=0.003, p=0.001, p<0.001, and p=0.041, respectively). The post-cardiotomy platelet and lymphocyte counts and postoperative first day lymphocyte counts were significantly lower in Group 2 (p<0.001, p=0.007, and p=0.009, respectively). Conclusion Post-cardiotomy neutrophil-to-lymphocyte ratio and neutrophilto- lymphocyte x platelet ratio can be easily accessible, inexpensive complete blood count parameters and may be more valuable in predicting major adverse events in patients undergoing coronary artery bypass grafting.

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Neutrophil-to-lymphocyte ratio for early renal failure under extracorporeal membrane oxygenation support for postcardiotomy shock

Cited by 5 publications

References 20 publications

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

Association of Derived Neutrophil-To-Lymphocyte Ratio With Prognosis of Coronary Heart Disease After PCI

The Effect of Blood Biochemistry and Hematological Parameters on the Development of Pseudoaneurysm

The effect of the relationship between post-cardiotomy neutrophil/lymphocyte ratio and platelet counts on early major adverse events after isolated coronary artery bypass grafting

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