Neutrophil to Lymphocyte Ratio Predicts SYNTAX Score in Patients With Non-ST Segment Elevation Myocardial Infarction

Kurtul, Serkan; Şarlı, Bahadır; Baktır, Ahmet Oğuz; Demirbaş, Melih; Sağlam, Hilal; Doğan, Yasemin; Şahin, Ömer; Akpek, Mahmut; Odabas, Huseyin; Arınç, Hüseyin; Kaya, Mehmet

doi:10.1536/ihj.14-175

Cited by 59 publications

(48 citation statements)

References 25 publications

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“…[24] We found in the present cohort CAC score but not NLR was significantly positively correlated with Syntax score, and the CAC score was an independent predictor for the Syntax tertiles. It was found that the ADAMTS-7 expression was upregulated in calcified arteries of rats with chronic renal failure, and in radial arteries of uraemic patients, which shed lights on the role of ADAMTS-7 in vascular calcification.…”

Section: Discussionmentioning

confidence: 57%

Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease

Zhou

et al. 2016

Medicine

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The metalloproteinase family of a disintegrin and metalloproteinase with thrombospondin motifs-7 (ADAMTS-7) was reported to be a novel locus associated with human coronary artery disease. This study aimed to investigate plasma ADAMTS-7 levels in stable obstructive CAD patients and elucidate the relationship between plasma ADAMTS-7 levels and the severity of CAD assessed by the Syntax score.This was a single center cross-sectional study performed in 182 CAD patients. ELISA was used to measure plasma ADAMTS-7 levels. All patients were divided into subgroup according to the ADAMTS-7 median in this cohort: high group with ADAMTS-7 ≥0.99 ng/mL and low group with ADAMTS-7 <0.99 ng/mL. Furthermore, all patients were divided into tertiles according to their Syntax scores (low group: Syntax score ≤10.0; moderate group: 10.0 18.0). We followed up the participants continuously until the first major adverse cardiovascular event (MACE) for a mean time of 22.0 months.Plasma ADAMTS-7 levels in the high Syntax score group were significantly higher compared with the low Syntax score group (3.29 [0.08–26.3] ng/mL vs 1.24 [0.15–8.78] ng/mL, P = 0.010). Plasma ADAMTS-7 levels were significantly positively correlated with the Syntax score tertiles (r = 0.157, P = 0.035). Logistic regression analysis indicated that the plasma ADAMTS-7 level was one of the independent predictors for the Syntax score tertiles (B = 1.118, 95% CI: 1.194–7.830, P = 0.020), together with HbA1c (B = 0.946, 95% CI: 1.248–5.312, P = 0.010), uric acid (B = –0.019, 95% CI: 0.974–0.988, P<0.001), and coronary artery calcium score (B = –0.001, 95% CI: 0.998–0.999, P < 0.001). Compared with the low ADAMTS-7 group, the high ADAMTS-7 group had significantly higher Syntax score (17.10±8.42 vs 14.96 ± 8.11, P = 0.047). Kaplan–Meier analysis showed patients in the high plasma ADAMTS-7 group tend to have a lower event-free survival rate than patients in the low plasma ADAMTS-7 group, unfortunately, no difference was detected (86.8% vs 88.0%, log rank = 0.314, P = 0.575).The plasma ADAMTS-7 level was positively correlated with the Syntax score significantly. The elevated plasma ADAMTS-7 level may be involved in the severity of disease in patients with stable coronary artery disease.

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Section: Discussionmentioning

confidence: 57%

Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease

Zhou

et al. 2016

Medicine

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“…Risk stratification is essential for adequate clinical decision making. The risk of morbidity and mortality in NSTEMI patients varies according to the presence of initial risk factors, clinical syndrome characteristics, and management strategy [2]. Cardiologists use risk scoring to determine the severity and complexity of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS) [2].…”

Section: Introductionmentioning

confidence: 99%

“…The risk of morbidity and mortality in NSTEMI patients varies according to the presence of initial risk factors, clinical syndrome characteristics, and management strategy [2]. Cardiologists use risk scoring to determine the severity and complexity of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS) [2]. The most commonly used scores are the thrombolysis in myocardial infarction (TIMI) risk score, the Global Registry of Acute Coronary Events (GRACE) score, and the synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score (SS).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Predictive Roles of Risk Scores of In-Hospital Major Adverse Cardiovascular Events in Patients with Non-ST Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Aktürk¹,

Aşkın²,

Taşolar³

et al. 2018

Med Princ Pract

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Significance of the Study• This study examines the relationship between risk scores and major adverse cardiovascular events (MACE) in patients with non-ST elevation myocardial infarction undergoing percutaneous coronary intervention. All risk scores were able to predict MACE, but the SYNTAX score II (SS-II) was also able to predict in-hospital mortality, nonfatal myocardial infarction, and stent thrombosis. The SS-II scoring system appears to be the most comprehensive scoring system as it is angiographic and has 6 clinical variables. The study population were selected from among 589 patients who underwent coronary angiography with a diagnosis of NSTEMI. TIMI and GRACE risk scores were calculated. SS and SS-II were calculated in all patients, and points were added according to the predefined algorithm, taking into account the other 6 clinical variables being monitored (age, sex, left ventricular ejection fraction, creatinine clearance, chronic obstructive pulmonary disease, and peripheral artery disease). Patients were classified into tertile 1 (SS < 22), tertile 2 (SS 23-32), and tertile 3 (SS > 32). Results: The group with high SS-II for PCI values in the risk scores were observed from tertile 1 to tertile 3 (from 25.0 ± 7.7 to 31.6 ± 9.4, p < 0.001, respectively). The SS-II score in patients with PCI was an independent predictor of MACE, in-hospital mortality, nonfatal myocardial infarction, and stent thrombosis (OR 1.082, 95% CI 1.036-1.131, p < 0.001). The overall MACE, inhospital mortality, and nonfatal myocardial infarction rates

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“…[8][9][10] The N/R ratio has been shown to be independently associated with the severity of coronary artery disease in patients with non-ST segment elevation myocardial infarction, and the ability of the N/L ratio to predict cardiovascular risk in various patient groups has been analyzed in several studies, including in patients with CKD. 7,[11][12][13][14][15][16] However, to date, the N/L ratio has not been investigated in elderly patients with CHF. In our study, we evaluated the association between the N/L ratio and the future risk of major cardiovascular events (MCE) in elderly patients admitted with CHF.…”

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confidence: 99%

Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Adverse Events in Elderly Patients With Chronic Heart Failure

Yan

et al. 2016

Int. Heart J.

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SummaryThe neutrophil-to-lymphocyte (N/L) ratio has been associated with poor outcomes in patients with cardiovascular diseases, but it has not been studied in elderly patients with chronic heart failure (CHF).In this study, we analyzed 1355 elderly patients admitted with CHF. A multivariate logistic regression model was used to assess the independent association of the N/L ratio with chronic kidney disease (CKD). The patients were then divided into tertiles according to the N/L ratios. We used Cox regression analysis to assess the association between the N/L ratio and subsequent major cardiovascular events (MCE), including cardiac death and rehospitalization for heart failure.In the multiple logistic regression analysis, the N/L ratio was identified as a risk factor for CKD in elderly patients with CHF (odds ratio [OR] = 1.170, 95% confidence interval [CI] 1.054 to 1.298, P = 0.003). The median follow-up period was 18 months. In a multivariate analysis with the lowest tertile as the reference, the highest tertile of the N/L ratio remained significantly associated with MCE (hazard ratio [HR] = 1.425, 95% CI 1.109 to 1.832, P = 0.006), cardiac death (HR = 1.747, 95% CI 1.032 to 2.958, P = 0.038), and rehospitalization for heart failure (HR = 1.461, 95% CI 1.108 to 1.927, P = 0.007).In elderly patients with CHF, the N/L ratio is one of the important risk factors for CKD and the highest tertile of the N/L ratio is associated with an increased risk for MCE. (Int Heart J 2016; 57: 615-621)

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Neutrophil to Lymphocyte Ratio Predicts SYNTAX Score in Patients With Non-ST Segment Elevation Myocardial Infarction

Cited by 59 publications

References 25 publications

Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease

Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease

Comparison of the Predictive Roles of Risk Scores of In-Hospital Major Adverse Cardiovascular Events in Patients with Non-ST Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Adverse Events in Elderly Patients With Chronic Heart Failure

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