Neutrophilic dermatosis of the dorsal hands: response to dapsone monotherapy

Abstract

Neutrophilic dermatosis of the dorsal hands is considered a rare and localized variant of Sweet's syndrome. Although the etiology is unknown, there are reports of association with infections, neoplasias, autoimmune diseases and medications. Histopathology shows a dense neutrophilic inflammatory infiltrate in the dermis. Treatment is based on the administration of systemic corticosteroids; however, a combination of medications is useful, given the frequency of relapses. The authors report a classic and clinically exuberant case of neutrophilic dermatosis of the dorsal hands, with excellent response to oral dapsone treatment, and offer a brief literature review.

A case of unilateral neutrophilic dermatosis of the dorsal hands

“…Systemic corticosteroids are the treatment of choice for most cases, and response is usually fast. Given the frequency of relapse, the use of dapsone and colchicine is useful, as they also serve as steroid-sparing agents 10 .…”