Neutrophilic dermatosis of the dorsal hands: an often under recognised and mistreated entity

Leecy, Tamazin; Anderson, Austen; Nida, Jamie Von; Harvey, Nathan T.; Wood, Benjamin A.

doi:10.1097/pat.0b013e32835cc1fa

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…The most common are hematologic disorders, such as myelodysplastic syndrome, acute leukemia, lymphoma, or other diseases in 21% of cases [7, 17–19]. In addition, solid neoplasms can be seen such as cancers of breast, kidney, colon, stomach, lung, and hypopharynx [1, 2, 7, 19–22]. Associated nonneoplastic disorders include inflammatory bowel disease, in approximately 15% of cases [7, 17, 22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, solid neoplasms can be seen such as cancers of breast, kidney, colon, stomach, lung, and hypopharynx [1, 2, 7, 19–22]. Associated nonneoplastic disorders include inflammatory bowel disease, in approximately 15% of cases [7, 17, 22]. Diverticulosis, diverticulitis, acute proctitis, and history of small bowel obstruction or bypass have also been reported [5].…”

Section: Discussionmentioning

confidence: 99%

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Neutrophilic Dermatosis of the Dorsal Hands: Report of a Case and Review of the Literature

Mobini

Sadrolashrafi

Michaels

2019

Case Reports in Dermatological Medicine

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Neutrophilic dermatosis of the dorsal hands is an underrecognized entity, which is a distributional variant of Sweet's syndrome. It is often clinically misdiagnosed as an infectious process in overwhelming majority of the cases and the treatment is therefore delayed. Also, its association with underlying systemic and neoplastic disorders makes the need for an accurate diagnosis more crucial. We present a 45-year-old Caucasian woman who was initially diagnosed as having a hand infection with unsuccessful courses of antibiotic therapy. A later biopsy revealed a diffuse dermal infiltrate of neutrophils with leukocytoclasis, vasculopathic changes, and marked papillary dermal edema. Patient responded rapidly to oral prednisone treatment. By sharing a new case and comprehensive review of available published literature, we intend to raise awareness of this underreported entity and emphasize the role of timely biopsy of the lesions that will not only lead to an accurate diagnosis, but also avoid unnecessary antibiotic treatments, potentially aggressive management strategies such as surgical debridement or amputation, and referrals to wound care centers. More importantly, it will prompt a search to exclude any possible association, particularly hematopoietic malignancies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neutrophilic Dermatosis of the Dorsal Hands: Report of a Case and Review of the Literature

Mobini

Sadrolashrafi

Michaels

2019

Case Reports in Dermatological Medicine

View full text Add to dashboard Cite

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“…The exact nature or classification of this neutrophilic dermatosis as a variant of SS, atypical PG, pustular vasculitis, an overlap of these conditions, or a distinct entity remains unclear. However, many authors have reported that pustular vasculitis of the hands, NDDH, atypical SS, and atypical vesiculobullous PG may represent different aspects of the same disease spectrum based on the multiple clinical, histopathological, and therapeutic overlaps among these conditions. We agree with this concept and believe that this disorder is a distinct entity that constitutes an overlap of these neutrophilic dermatoses.…”

mentioning

confidence: 99%