Neutrophils From Acute Pancreatitis Patients Cause More Severe In Vitro Endothelial Damage Compared With Neutrophils From Healthy Donors and Are Differently Regulated by Endothelins

Abstract

These results show that neutrophils taken from healthy donors damage the endothelium by a mechanism dependent on ETs acting via ET(A) receptor, whereas neutrophils from acute pancreatitis patients cause more severe damage that is not dependent on ETs in the in vitro system used.

Postendoscopic retrograde cholangiopancreatography pancreatitis

“…In-vitro studies have shown that in patients with acute pancreatitis, activated neutrophils cause severe endothelial cell damage [18]. Acute pancreatitis can lead to a systemic inflammatory response syndrome with increased plasma levels of tumor necrosis factor-a (TNF-a), interleukin (IL)-1, IL-6, and IL-8.…”

Effect of Salvia miltiorrhizae on Pulmonary Apoptosis of Rats with Severe Acute Pancreatitis or Obstructive Jaundice

“…Salvia miltiorrhizae is able to provide a multichannel protection for the lungs mainly through the following possible mechanisms: (1) to improve microcirculation, increase energy supply for cells, and reduce the formation of lactic acid; (2) to protect the integrity of cytoplasmic membrane, and thereby reduce or prevent calcium influx and lessen ischemia-reperfusion injury of tissues; (3) to inhibit the adhesion of PMNs to endothelial cells, reduce the activation of PMNs, protect the barrier function of intestinal mucosa, and mitigate endotoxemia-elicited multi-organ damage; (4) to remove oxygen free radicals, inhibit platelet aggregation, modulate the metabolism of inflammatory mediators, reduce the production of TXA 2 , and expand blood vessels [9,12,13,25,26]. Apoptosis, also known as programmed cell death, is a self-protective strategy employed by the body for elimination of destroyed cells.…”

Serum Proinflammatory Cytokine Levels and White Blood Cell Differential Count in Patients with Different Degrees of Severity of Acute Alcoholic Pancreatitis

“…Again, the studies (26) showed that PMN-elastase serum levels are significantly higher in severe AP than in mild AP during the first 12-24 hours of the disease. Neutrophils from patients suffering from acute pancreatitis cause more severe in-vitro endothelial damage compared with neutrophils from healthy donors and are differently regulated by endothelins (27). T cells, natural killer (NK) cells, and monocytes/macrophages are major sources of cytokines, but it has been shown that neutrophils also have the ability to synthesize and release immunoregulatory cytokines (28).…”