Nevirapine: Most Common Cause of Cutaneous Adverse Drug Reactions in an Outpatient Department of a Tertiary Care Hospital

Pawar, Mayur P.

doi:10.7860/jcdr/2015/13672.6768

Cited by 13 publications

(14 citation statements)

References 21 publications

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“…Several studies have reported that nevirapine, one of the first‐generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) widely used to fight AIDS by blocking the replication of HIV, has the potential to cause SJS/TEN . The FDA has also included this severe adverse effect in its boxed warning for the drug since 2000 .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported that nevirapine, one of the firstgeneration nonnucleoside reverse transcriptase inhibitors (NNRTIs) widely used to fight AIDS by blocking the replication of HIV, has the potential to cause SJS/TEN. 29 The FDA has also included this severe adverse effect in its boxed warning for the drug since 2000. 30 In our study, however, a much lower frequency of nevirapine-induced SJS/TEN was found in the Asian countries included in the study than has previously been found in European countries.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label

Wang

Chen

Tassaneeyakul

et al. 2018

Clin Pharma and Therapeutics

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Specific ethnic genetic backgrounds are associated with the risk of Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple-country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998-2017. A total 1,028 SJS/TEN cases were identified with the algorithm of drug causality for epidermal necrolysis. Furthermore, those medications labeled by the US Food and Drug Administration (FDA) as carrying a risk of SJS/TEN were also compared with the common causes of SJS/TEN in Asian countries. Oxcarbazepine, sulfasalazine, COX-II inhibitors, and strontium ranelate were identified as new potential causes. In addition to sulfa drugs and beta-lactam antibiotics, quinolones were also a common cause. Only one acetaminophen-induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by the FDA were not found to have caused any of the cases in the Asian countries investigated in this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label

Wang

Chen

Tassaneeyakul

et al. 2018

Clin Pharma and Therapeutics

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“…These findings are supported by previous studies which indicate that antiretroviral drugs commonly lead to drug eruptions. 22,23 In the present study ceftriaxone was most common antibacterial associated with adverse reactions {21/151(14.68%)}, especially hypersensitivity reactions such as rigors, bronchospasm, urticaria etc. The reason could be that it is the most commonly used antibacterial in our setting.…”

Section: Discussionmentioning

confidence: 59%

Pattern of Adverse Drug Reactions Reported with Use of Antimicrobial Drugs in a Tertiary Care Hospital

Pore¹,

Burute²,

Shinde³

et al. 2018

JYP

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“…13 Selain itu, mungkin disebabkan karena memang indikasi pemberian obat ARV pada pasien HIV/AIDS adalah CD4 <350 sel/ mm 3 sehingga populasi yang ditemukan pada penelitian ini banyak pada CD4 < 200 sel/mm 3 . 10 Pada penelitian ini didapatkan bahwa erupsi obat ARV pada pasien HIV/AIDS terbanyak disebabkan oleh nevirapin yaitu 104 kasus (82,5%). Sampai saat ini belum ada pemeriksaan atau tes untuk menentukan obat yang menyebabkan erupsi alergi obat.…”

Section: Pembahasanunclassified

“…Hasil penelitian Mayur dkk menyatakan bahwa nevirapin merupakan obat ARV yang paling umum menyebabkan erupsi alergi obat. 10 Penelitian yang dilakukan Mohamed dkk dan Leelavathy dkk juga menyatakan hal yang sama. 15,16 Selain nevirapin, ada beberapa obat ARV yang juga dikaitkan dengan kejadian erupsi alergi obat seperti zidovudin (2,9%), lamivudin (2,9%), tenofovir (5-7%) dan efavirenz (14,5%).…”

Section: Pembahasanunclassified

Manifestasi Erupsi Alergi Obat Antiretroviral Pada Pasien HIV/AIDS di Klinik Teratai Rsup Dr. Hasan Sadikin Bandung Periode 2005 – 2014

Armeinesya

Rowawi²,

Hamda³

2018

jsk

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Kasus human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) telah menjadi masalah kesehatan dunia. High active antiretroviral therapy (HAART) telah menurunkan angka kematian dan kesakitan pada pasien HIV. Pasien HIV memilki risiko tinggi mengalami erupsi alergi obat dibandingkan masyarakat umum. Penelitian ini bertujuan untuk mengindentifikasi manifestasi erupsi alergi obat ARV pada pasien HIV/AIDS periode 2005–2014 di Klinik Teratai RSUP Dr. Hasan Sadikin Bandung. Penelitian ini menggunakan pendekatan cross-sectional. Data dikumpulkan dari rekam medis pasien HIV/AIDS dengan erupsi alergi obat ARV di Klinik Teratai RSUP Dr. Hasan Sadikin Bandung tahun 2005–2014. Dalam penelitian ini didapatkan sebanyak 111 pasien HIV/AIDS mengalami erupsi alergi obat karena ARV. Erupsi alergi obat ARV banyak terjadi pada wanita (55%) dan pada rentang usia 20-29 tahun (55%). Jumlah CD4 pada pasien HIV/AIDS dengan erupsi alergi obat saat pertama kali terdiagnosis HIV terbanyak adalah <200 sel/mm3 (55%). Manifestasi kulit yang paling umum terjadi adalah ruam makulopapular (89,7%). Reaksi erupsi alergi obat umumnya disebabkan oleh nevirapin (82,5%). Dari penelitian ini didapatkan bahwa ruam makulopapular merupakan manifestasi erupsi alergi obat ARV yang paling sering muncul. Obat yang paling banyak ditemukan menyebabkan erupsi alergi obat adalah nevirapin. Kata kunci: erupsi alergi obat, HIV/AIDS, obat ARV

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Nevirapine: Most Common Cause of Cutaneous Adverse Drug Reactions in an Outpatient Department of a Tertiary Care Hospital

Cited by 13 publications

References 21 publications

The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label

The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label

Pattern of Adverse Drug Reactions Reported with Use of Antimicrobial Drugs in a Tertiary Care Hospital

Manifestasi Erupsi Alergi Obat Antiretroviral Pada Pasien HIV/AIDS di Klinik Teratai Rsup Dr. Hasan Sadikin Bandung Periode 2005 – 2014

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