Nevoid Hyperkeratosis of the Areola

Unilateral Nevoid Hyperkeratosis of the Nipple and Areola Treated Successfully With Carbon Dioxide Laser

“…This type may be bilateral. The third type is idiopathic hyperkeratosis of the nipple and areola, this rare condition is also called naevoid hyperkeratosis and it appears predominantly in women in the second or third decade of life, and is usually bilateral [4,5]. But there are reports of unilateral lesions also [6,7] like our patient.…”

“…Typically, NHNA presents as hyperkeratotic, hyperpigmented plaques of the nipple and/or areola [4,5]. Desquamation [11] or Yellowish discoloration [12,13] or of the areas may also be present.…”

Treatment of Nevoid Hyperkeratosis of the Nipple and Areola Using a Radiofrequency Surgical Unit

“…11 The lesions have an undesirable appearance. 2,5,7,14,15 Cryotherapy 8,9 and the CO 2 laser 10 are the other treatment modalities for NHNA reviewed in the literature. In our case, the main reason for the patient to present for treatment was the undesirable appearance of the lesion.…”

Hyperkeratosis of the Nipple and Areola

“…Thus, the diagnosis of hyperkeratosis of the nipple and areola would be reserved to the dermatosis when it occurs alone or is associated with ichthyosis, acanthosis nigricans, or occurs secondary to hormonal changes, 6 an internal malignancy, 9 or a lymphoma. 4,10 Although several articles [2][3][4] refer to the condition as "nevoid hyperkeratosis of the nipple and areola," one wonders whether the term nevoid is truly applicable. Consequently, we suggest that nevoid be deleted.…”

“…Several case reports in the literature [2][3][4] refer to the classification of hyperkeratosis of the nipple and areola suggested by Levy-Franckel 5 in 1938, who described the following 3 types: type 1, hyperkeratosis of the nipple and areola representing an extension of a verrucous (epidermal) nevus (this type is usually unilateral); type 2, hyperkeratosis of the nipple and areola associated with other dermatoses such as ichthyosis, acanthosis nigricans, Darier disease, and lymphoma (this type may be bilateral); and type 3, also known as idiopathic or nevoid hyperkeratosis of the nipple and areola, an unusual variant that appears predominantly in women in the second or third decade of life (this type is usually bilateral and according to some authors may appear at puberty, 6 during pregnancy, 7,8 and in men with prostate cancer treated with diethylstilbestrol 9 ). Considering the description of type 1 above, it is apparent that this is an epidermal nevus that happens to involve the nipple and/or the areola, and in this respect it should not be considered hyperkeratosis of the nipple and areola.…”