Nevus of Ota: A series of 15 cases

Sekar, Shanmuga; Kuruvila, Maria; Pai, Harsha

doi:10.4103/0378-6323.39695

Cited by 31 publications

(20 citation statements)

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“…The bluish discoloration of the lesion is the result of Tyndall effect of the dermal melanocytes. [1920]…”

Section: Discussionmentioning

confidence: 99%

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Mukhopadhyay¹

2013

Indian J Dermatol

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Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino's classification to incorporate the nevus of Ito into the classification for the Ota's nevus may be appropriate.

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“…The bluish discoloration of the lesion is the result of Tyndall effect of the dermal melanocytes. [1920]…”

Section: Discussionmentioning

confidence: 99%

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Mukhopadhyay¹

2013

Indian J Dermatol

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“…30 A 3:1 female predominance suggests a possible hormonal component but may also reflect more frequent presentation due to cosmetic concerns. [31][32][33] Clinically, the lesion is characterized by partially confluent pigmented macules and occasional papules that form a poorly demarcated mottled tan to blue-gray patch of the facial skin or mucous membranes, typically in the distribution of the first 2 branches of the trigeminal nerve. Ten percent are bilateral, whereas roughly two-thirds are associated with ocular melanocytosis of the ipsilateral sclera or conjunctiva.…”

Section: Discussionmentioning

confidence: 99%

“…33,[36][37][38][39] Autosomal recessive inheritance has been proposed to explain extremely rare familial cases; however, Agero et al 40 suggest autosomal dominant transmission with variable penetrance in a recent case report. Nevus of Ota has been observed in association with the closely related nevus of Ito, 41,42 Mongolian spots, 31 hemangiomas and Takayasu arteritis, 43 Sturge-Weber and Klippel-Trenaunay-Weber syndromes, 44,45 and ipsilateral sensorineural hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Melanotic Schwannoma Arising in Association With Nevus of Ota: 2 Cases Suggesting a Shared Mechanism

Trufant¹,

Brenn²,

Fletcher³

et al. 2009

The American Journal of Dermatopathology

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Melanotic schwannoma is a rare markedly pigmented peripheral nerve sheath tumor comprising cells with prominent melanization and schwannian features. The psammomatous variety is associated with Carney complex, a multiple neoplasia syndrome with spotty skin pigmentation. We present the first 2 reported cases of melanotic schwannoma arising in patients with a history of nevus of Ota, a rare dermal melanosis believed to represent a failure of melanocyte migration to the epidermis during embryogenesis. Case 1 involves a 40-year-old woman with a 1.8-cm, deeply pigmented, trigeminal nerve mass and pigmentation of the maxillary sinus mucosa and bone. Case 2 involves a 53-year-old woman with a 1.5-cm mass adjacent to the clavicle. Microscopically, both masses consist of partially encapsulated epithelioid and spindle cells with abundant melanin pigment, arising in association with peripheral nerves. Morphological, immunohistochemical, and ultrastructural features support a diagnosis of melanotic schwannoma. No psammoma bodies are noted, and neither patient exhibits any additional features of Carney complex. Melanotic schwannoma is most often benign but has been associated with malignant behavior in some cases. Distinguishing this nerve sheath tumor from malignant melanoma can be difficult but is of great clinical importance due to differences in prognosis and treatment.

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“…It is common in Asians. [123456789101112] It is a benign condition, but may cause impairment in the quality of life due to the cosmetic disfigurement. Various treatment modalities have been used such as dermabrasion, cryotherapy, surgical removal and skin grafting.…”

Section: Introductionmentioning

confidence: 99%

Melanin index in assessing the treatment efficacy of 1064 nm Q switched Nd-Yag laser in nevus of Ota

Sethuraman¹,

Sharma²,

Sreenivas³

2013

J Cutan Aesthet Surg

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Background:Q-switched neodymium-yttrium aluminium-garnet (Q switched Nd-Yag) laser has been used in the treatment of nevus of Ota in all skin types with variable success rate. Data with an objective assessment parameter to this laser treatment is lacking.Objective:To evaluate the utility of melanin index in assessing the treatment response and also determine the efficacy and safety of the Q-switched Nd-Yag laser (1064-nm) in the treatment of nevus of Ota in Fitzpatrick skin types IV and V.Materials and Methods:A total of 35 patients treated with Nd-Yag laser were studied. The objective improvement (pigment clearance) was determined by melanin index from two fixed points: A1, 2 cm below the pupil at the mid pupillary line (when the gaze is fixed); A2, the most prominent part of zygoma. The melanin index in these two areas was recorded as M1 and M2, respectively. The subjective clinical improvement was determined by the physician and the patient global assessment score.Results:The mean baseline melanin indices M1 and M2 were 59.54 ± 9.72 and 59.02 ± 9.16, respectively. At the last visit the mean M1 and M2 decreased to 53.8 ± 8.55 (P < 0.001) and 54.13 ± 6.01 (P < 0.001), respectively. Patient and the physician global assessment score showed that 26 (74.3%) and 20 (57.14%) patients, respectively, had >50% pigment clearance.Conclusion:The melanin index, a simple non-invasive parameter is useful in assessing the treatment response more objectively. The 1064-nm Q-switched Nd-Yag laser offers good improvement in patients with nevus of Ota in darker skin types IV/V.

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Nevus of Ota: A series of 15 cases

Abstract: Tanino class II was the most common type observed in our studies. A few rarer associations such as nevus of Ito and hemangioma were also noted in our patients.

Cited by 31 publications

References 0 publications

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Melanotic Schwannoma Arising in Association With Nevus of Ota: 2 Cases Suggesting a Shared Mechanism

Melanin index in assessing the treatment efficacy of 1064 nm Q switched Nd-Yag laser in nevus of Ota

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