Nevus Sebaceous Accompanying Secondary Neoplasms and Unique Histopathologic Findings

Abstract

Nevus sebaceous (NS) is a type of classical nevus or congenital malformation that is often present at birth and commonly involves the scalp or face. The lesion usually presents as a linear, yellow, hairless, and verrucous plaque. It has been well-established that several benign and malignant tumors can develop from the NS; however, there have been no reports about ectopic fat cells in the dermis, and cornoid lamella arising from the NS. We report a case of NS on the scalp with accompanying unusual histopathologic findings.

Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions

“…However, subsequent studies have suggested that basal cell carcinomas were misdiagnosed and that nevus sebaceus is actually associated with trichoblastoma, a benign hair follicle tumor, whose pathologic features may mimic those of basal cell carcinoma [8]. Other common tumors which may emerge include syringocystadenoma papilliferum and trichilemmoma [5,9]. The prurigo nodularis present in our patient's tumor is postulated to have resulted Approximately ten to 20 percent of nevus sebaceus is associated with a syringocystadenoma papilliferum [9].…”

“…Other common tumors which may emerge include syringocystadenoma papilliferum and trichilemmoma [5,9]. The prurigo nodularis present in our patient's tumor is postulated to have resulted Approximately ten to 20 percent of nevus sebaceus is associated with a syringocystadenoma papilliferum [9]. Histologically, syringocystadenoma papilliferum is a benign adnexal tumor of apocrine derivation composed of papillary projections and cystic ducts lined by cuboidal or columnar cells with abundant basophilic cytoplasm and usually a connection to the overlying epidermis [10].…”

The Epidemiology of Non-Melanocytic Benign and Malignant Skin Tumors in Pediatric Patients Attending to the Dermatology Department

“…More than 90% of sebaceous nevi involve the head, mainly on the scalp, and such lesions present at birth. In 10-30% of cases, secondary skin neoplasms develop on the nevus, usually in adulthood [ 12 , 13 ]. No other skin neoplasms were found on the nevus sebaceous in our patients, as our study population comprised young patients under the age of 16.…”

An Organoid Nevus with Four Adnexal Differentiations

“…In other words, it is a pluripotential tumour. [ 1 ] This differentiation is usually benign but sometimes malignant[ 2 ] A 34-year-old woman was admitted to evaluate an asymptomatic yellowish linear lesion on the right lower lid since childhood. She noted that the lesion is congenital, but its surface showed a raised appearance after puberty.…”

“…[ 3 ] The most common benign tumour that develops secondarily within NS is syringocystadenoma papilliferum, followed by trichoblastoma, nodular hidradenoma, syringoma and trichilemmoma. [ 2 5 ] The rate of malignant transformation within NS is low, ranging from 0% to 0.8%. [ 3 ] The most frequent malignant tumour within NS is basal cell carcinoma (BCC),[ 2 5 ] but it is a very rare event.…”