New 2-sulfonamidothiazoles substituted at C-4: synthesis of polyoxygenated aryl derivatives and in vitro evaluation of antifungal activity

Beuchet, P.

doi:10.1016/s0223-5234(99)00215-9

Cited by 29 publications

(9 citation statements)

References 6 publications

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“…It is also required for diabetic patients to improve their carbohydrate catabolism. Moreover, a large number of thiazole-containing pharmaceutical compounds are present in several drug molecules, such as Tiazofurin (antineoplastic mediators), Bleomycin [ 16 ], Ritonavir (anti-HIV medication) [ 17 ], Fanetizole and Meloxicam (arthritis mediators) [ 18 ], Nizatidine (antiulcer mediator) [ 19 ], Imidacloprid (insecticide), and sulfathiazole as an antibiotic [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

2018

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Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

2018

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“…2-Aminothiazoles have considerable interest from a therapeutic point of view because of their utility as intermediates in the synthesis of antibiotics such as the well-known sulfa drugs [3]. They have been reported in the literature as antimicrobial [4], antifungal [5], anti-inflammatory activity [6], anesthetic [7], anti-hypertesive [8] and antiviral drugs [9]. 2-Aminothiazole derivatives have been also used as intermediates in the synthesis of various types of dyes [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel 2-Amino-5-arylazothiazole Disperse Dyes for Dyeing Polyester Fabrics and Their Antimicrobial Activity

2016

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Abstract:The present work describes the synthesis of a series of four novel biologically active 2-amino-5-arylazothiazole disperse dyes containing the sulfa drug nucleus. The structures of the synthesized thiazole derivatives are confirmed using UV-spectrophotometry, infrared and nuclear magnetic resonance techniques and elemental analysis. The synthesized dyes are applied to polyester fabrics as disperse dyes and their fastness properties to washing, perspiration, rubbing, sublimation, and light are evaluated. The synthesized compounds exhibit promising biological efficiency against selected Gram-positive and Gram-negative pathogenic bacteria as well as fungi.

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“…In continuation of our previous work [5][6][7][8] on the synthesis of S/N heterocyclic azo compounds with different applications, such as dyeing polyester fabrics and bioactive function, the present work describes the synthesis of several new S/N heterocyclic mono azo compounds based on the 2-aminothiazole moiety, and their applications as biologically active materials. Diverse biological activities have been found to be associated with thiazolidine derivatives, including anesthetic [3], antiviral [4], antimicrobial [9], bactericidal [10], anti-inflammatory [11], fungicidal [12,13], and anticonvulsant [14][15][16] properties. It is well known that 2-aminothiazole can exhibit amino-imino tautomeric configurations in nature, and the amino configuration is the predominant tautomer [17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities

Khalifa

Mohamed

Alshehri

2015

Maced. J. Chem. Chem. Eng.

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A reactivity study of both the amino group and the aryl substituent of a newly synthesized 2-amino-5-(4-acetylphenylazo)-thiazole compound and its derivatives via various electrophilic reagents was performed to obtain new bioactive chalcone, imine, and pyrazole-thiazolidine derivatives. The synthesized compounds were chemically elucidated by analytical and spectral methods, and biologically evaluated in vitro and in vivo for their toxicity and antioxidant activity based on liver function enzymes.Keywords: 2-aminothiazole; chalcone; imine; pyrazole; azo coupling; biological activities СИНТЕЗА НА НОВИ ДЕРИВАТИ НА 2-АМИНО-5-АРИЛТИАЗОЛ И НИВНА БИОЛОШКА АКТИВНОСТ: ПРОЦЕНА НА НИВНАТА ТОКСИЧНОСТ И АНТИОКСИДАТИВНА ЕНЗИМСКА АКТИВНОСТИзвршено е испитување како на аминогрупата така и на арилсупституентот на ново синтетизирано соедиенние на 2-амино-5-(4-ацетилфенилазо)-тиазол и неговите деривати преку разни електрофилни реагенси за да се добијат нови биоактивни халконски, имински и пиразолти-азолидински деривати. Синтетизираните соединенија беа идентификувани преку аналитички и спектрални методи, а потоа беа и биолошки евалуирани in vitro и in vivo за нивната токсичност и антиоксидативна активност преку ензими од црниот дроб.

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New 2-sulfonamidothiazoles substituted at C-4: synthesis of polyoxygenated aryl derivatives and in vitro evaluation of antifungal activity

Cited by 29 publications

References 6 publications

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

Synthesis of Some Novel 2-Amino-5-arylazothiazole Disperse Dyes for Dyeing Polyester Fabrics and Their Antimicrobial Activity

Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities

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