New 5′-Nucleotidase Inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB from<i>Areca catechu</i>; Part I. Isolation and Biological Properties

Uchino, Keijiro; Matsuo, Toshio; Iwamoto, Mitsuo; Tonosaki, Yasuhiro; Fukuchi, Akira

doi:10.1055/s-2006-962487

Cited by 15 publications

(9 citation statements)

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“…2). The IR absorption spectra of CC‐517 agreed with previous results [11]. The effects of CC‐517 from A. catechu on the hydrolytic activity of elastase are summarized in Table I.…”

Section: Resultsmentioning

confidence: 99%

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Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent

Lee¹,

Cho

Park³

et al. 2001

Intern J of Cosmetic Sci

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We have previously screened 150 medicinal plants for the inhibition of elastase and found significant inhibitory effects of the extracts of Areca catechu L. on the ageing and inflammation of skin tissues. To isolate and identify the compounds having biological activity, they were further purified by each fraction of solvents, silica gel column chromatography, preparative TLC and reversed-phase HPLC. The peak in HPLC, which coincided with the inhibitory activity against elastase, was identified as a phenolic substance by using various colorimetric methods, UV and IR. IC(50) values of this phenolic substance were 26.9 mug mL(-1) for porcine pancreatic elastase (PPE) and 60.8 mug mL(-1) for human neutrophil elastase (HNE). This phenolic substance showed more potent activity than that of reference compounds, oleanolic acid (76.5 mug mL(-1) for PPE, 219.2 mug mL(-1) for HNE) and ursolic acid (31.0 mug mL(-1) for PPE, 118.6 mug mL(-1) for HNE). According to the Lineweaver-Burk plots, the inhibition against both PPE and HNE by this phenolic substance was competitive inhibition with the substrate. The phenolic substance from A. catechu effectively inhibited hyaluronidase activity (IC(50) : 210 mug mL(-1) ). These results suggest that the phenolic substance purified from A. catechu has an anti-ageing effect by protecting connective tissue proteins.

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“…2). The IR absorption spectra of CC‐517 agreed with previous results [11]. The effects of CC‐517 from A. catechu on the hydrolytic activity of elastase are summarized in Table I.…”

Section: Resultsmentioning

confidence: 99%

“…This active compound in HPLC was designated the ‘CC‐517’ and used as the sample. The CC‐517 was identified as a phenolic substance by using various specific methods [11].…”

Section: Methodsmentioning

confidence: 99%

Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent

Lee¹,

Cho

Park³

et al. 2001

Intern J of Cosmetic Sci

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“…It is well known for its therapeutic uses in dermatological, cardiovascular and respiratory diseases. Further, due to the presence of great percentage of acidic compounds the same is also used to reduce pH that inhibits the growth of microbial cells [36,38,56,84]. Catechin Obtained from the same is known antioxidant and reported to exhibit In vivo antioxidant properties against free radical attack [67,73].…”

Section: Discussionmentioning

confidence: 99%

Amazing Antimicrobial and Wound Healing Potential of Acacia Catechu Bark Extracts- A Review

Tiwari¹,

Tiwari

2021

Asian J Pharm Clin Res

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Plants are not only the source of food, oxygen, and shelter, but the same are also a potential foundation of medicines. Many natural and plant-derived antimicrobial and wound healing compounds have been recognized. In the present review, we have studied the main bioactive components of Acacia catechu with their medicinal roles. Most of these bioactive components are secondary metabolites which are produced by plants as side products of certain physiological reactions and are of no use for the plant itself. These components have been reported for their medicinal properties. In this review, we have mentioned some antibacterial, antifungal, and wound healing properties of A. catechu with its known bioactive components. The aim of this review article is, to enlist the possible potent bioactive components of the plant, against pathogenic microbes that can replace the use of chemicals and synthetic antibiotics for the treatment of skin infections and other diseases.

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“…Polyphenolic substances which possess antitumour activity and inhibit 5'-nucleotidase from a variety of sources have been isolated from the seeds of Areca catechu (betel nuts) Uchino et al, 1988) as well as from wine grapes . Since murine macrophages are directly stimulated by these inhibitors and no general cytotoxic effects are observed, the antitumor activity might be through potentiation of the immunity of host animals (Matsuo et al, 1989).…”

Section: '-Nucleotidase Inhibitorsmentioning

confidence: 99%

5′-Nucleotidase: molecular structure and functional aspects

Zimmermann

1992

Biochemical Journal

806

701

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New 5′-Nucleotidase Inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB fromAreca catechu; Part I. Isolation and Biological Properties

Cited by 15 publications

References 1 publication

Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent

Anti‐elastase and anti‐hyaluronidase of phenolic substance from Areca catechu as a new anti‐ageing agent

Amazing Antimicrobial and Wound Healing Potential of Acacia Catechu Bark Extracts- A Review

5′-Nucleotidase: molecular structure and functional aspects

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