New alkylamide from the stems of Zanthoxylum nitidum

Abstract

A new alkylamide, named (2E,6E,8E)-N-(2-methylpropyl)-10-oxo-2,6,8-decatrienamide (1), together with 22 known compounds (2-23), were isolated from the stems of Zanthoxylum nitidum. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR spectroscopy. The isolated compounds exhibited slightly antioxidant activities through DPPH and ABTS radical scavenging assays but showed no antibacterial activity against Streptococcus mutans ATCC2517, a dental caries causing bacteria.

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

“…It is worth noting that the names of some of the plants used in the studies reviewed were the “synonyms” as shown in plant databases. For example, some studies like Wu et al (2007) and Fan et al (2019) reported on Zanthoxylum simulans while Yang and Chen (2008) , Yang et al (2009) , Chakthong et al (2019) , Sepsamli and Prihastanti, (2019) , Lu et al (2020a) and Lu et al (2020b) reported on Zanthoxylum nitidum instead of the accepted nomenclature, “Zanthoxylum bungeanum Maxim”. This issue was noted in several other papers, such as Chrian et al (2011) , Rodriguez-Guzman et al (2011) , Okafor et al (2017) , and Wansi et al (2009) .…”

Large‐scale separation of acetylcholinesterase inhibitors from Zanthoxylum nitidum by pH‐zone‐refining counter‐current chromatography target‐guided by ultrafiltration high‐performance liquid chromatography with ultraviolet and mass spectrometry screening

“…DC (Rutaceae) . It is widely distributed throughout the southeastern part of China, and could also be found in India, northern Queensland and Australia . Contemporary pharmacological studies explained that Z. nitidum has anti‐tumor , antibacterial and anti‐inflammation effects.…”

The crystal structure of 3-methoxyphenanthridin-6(5H)-one, C14H11NO2

“…In recent years, phenanthridinone has been found to be a key core unit in some natural products with important biological activities [6][7][8] and drug molecules for the treatment of nerve diseases [9][10][11]. Thus, the synthesis and crystal structures of various phenanthridinone derivatives have attracted great attention [5,12].…”