New amide alkaloids and carbazole alkaloid from the stems of Clausena lansium

Sun, Xing-Yan; Li, Chuang‐Jun; Ma, Jie; Zang, Yingda; Huang, Ji-Wu; Chen, Nai‐Hong; Wang, Xiaoliang; Zhang, Dongming

doi:10.1016/j.fitote.2021.104999

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…Geranylated phyto-carbazole alkaloids (clauselansiumines A-B) along with other carbazole alkaloids from the stem and leaves of C. lansium revealed remarkable neuroprotective effects (EC 50 0.48 to 12.36 µM) against 6-OHDA-induced apoptosis in SH-SY5Y cells [70]. The protective effect of phyto-carbazoles (10 µM) was also reported on primary neurons against oxygen glucose deprivation (OGD) injury [71].…”

Section: Phyto-carbazole Alkaloids From the Genus Clausenamentioning

confidence: 97%

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Tan

Sharma

2022

Antioxidants

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Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and Zanthoxylum). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.

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Section: Phyto-carbazole Alkaloids From the Genus Clausenamentioning

confidence: 97%

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Tan

Sharma

2022

Antioxidants

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“…Liu et al extracted (+)-(3 S ,4 R ,5 S ,6 S )-clauselansine C from wampee seeds and confirmed its neuroprotective activity . Recently, three more new amide alkaloids were found in wampee seeds, including acetylclausenamide, anhydroclausenamide, and 1-chloro-benzenepropanamide …”

Section: Chemical Compositionsmentioning

confidence: 99%

“…62 Recently, three more new amide alkaloids were found in wampee seeds, including acetylclausenamide, anhydroclausenamide, and 1-chloro-benzenepropanamide. 50 At least 30 amide alkaloids were extracted and characterized from different portions of the wampee. The amide alkaloids isolated from wampee were summarized in Table 2.…”

Section: Carbazole Alkaloidmentioning

confidence: 99%

“…49 Recently, a new carbazole alkaloid, called claulansine X, has been identified in the ethanol extract of the wampee stem, exhibiting a moderate neuroprotective influence on the PC12 cell line. 50 In short, more than 40 carbazole alkaloids have been isolated and identified from different parts of the wampee and are summarized in Table 2. They are an essential and characteristic feature of a wampee.…”

Section: Volatile Compoundsmentioning

confidence: 99%

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Comprehensive Review of Phytochemical Profiles and Health-Promoting Effects of Different Portions of Wampee (Clausena lansium)

et al. 2023

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Clausena lansium, commonly known as wampee, is a subtropical fruit from the Rutaceae family characterized by its high nutrient content and numerous bioactive substances. This low-fat fruit is abundant in fiber, vitamins, minerals, and essential amino acids. Wampee has been found to contain several bioactive compounds, including essential oils, phenolic compounds, and alkaloids. These bioactive constituents provide numerous health-enhancing properties, such as antioxidant, neuroprotective, anticarcinogenic, anti-inflammatory, hepatoprotective, antidiabetic, and antimicrobial effects. The relationship between these compounds and their impacts on health has been explored in various studies. While the disease-prevention efficacy of C. lansium has been established, additional research is necessary to elucidate the precise mechanisms and metabolic pathways involved. This paper presents a comprehensive review of wampee, focusing on its bioactive compounds, the beneficial effects derived from its consumption, and the evidence supporting the development of wampee-based functional foods in future studies.

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“…(+)-ζ-Clausenamide ( 1 ) and its O -acetylated derivatives 1a , b were isolated from a Chinese medicinal plant Clausena lansium . 7 8 The other eight-membered N -containing azocine ring, fused with an indole nucleus, is in (+)-balasubramide ( 2 ) isolated from a rainforest plant in Sri Lanka, Clausena indica . 9…”

Section: Table 1 Methylation Study Of ζ-Clausenamidesmentioning

confidence: 99%

Synthesis of Clausena Alkaloids Using Unique Ring Expansion of Dihydroisoquinolines and Their Cholinesterase Inhibitory Activity

et al. 2023

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A facile and direct synthetic entry to the carbon skeleton of Clausena alkaloids, the benzo[d]azocin-4-one, is reported featuring the ring expansion of 1-phenyldihydroisoquinoline derivatives initially triggered by oxazolone under environmentally benign conditions in a one-pot procedure. Functionalization of the eight-membered lactam framework provided a set of Clausena alkaloid derivatives. Some derivatives show a promising inhibition toward acetylcholinesterase and a better selectivity index than the previously used Alzheimer’s disease (AD) drug, tacrine, and the currently used AD drug, galantamine.

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New amide alkaloids and carbazole alkaloid from the stems of Clausena lansium

Cited by 10 publications

References 13 publications

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Comprehensive Review of Phytochemical Profiles and Health-Promoting Effects of Different Portions of Wampee (Clausena lansium)

Synthesis of Clausena Alkaloids Using Unique Ring Expansion of Dihydroisoquinolines and Their Cholinesterase Inhibitory Activity

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