2016
DOI: 10.1515/nuka-2016-0013
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New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Abstract: A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields. The in vivo biodistribution of 99mTc-AEDP has been investigated and compared with two reference compounds Tc-99m methylene diphosphonate (99mTc-MDP) and Tc-99m (1-hydroxyethylidene) diphosphonate (99mTc-HEDP). The biodistribution studies have demonstrated a high uptake of the radiotracer 99mTc-AEDP in the bone and a rapid clearance from the blood (suc… Show more

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Cited by 5 publications
(3 citation statements)
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“…The HEDP was radiolabeled with 99m Tc using the method described in the literature (Assaad, 2016). Briefly, radiolabeling of 2 mg HEDP was carried out by the addition of an appropriate volume, of SnCl 2 solution (20 mg/ml in 0.5 N HCl) followed by adjustment to pH 6-7, and the addition of 18.5 MBq freshly eluted 99m TcO 4 − in 1 ml of saline solution.…”
Section: Labeling Of Hedp With 99m Tcmentioning
confidence: 99%
“…The HEDP was radiolabeled with 99m Tc using the method described in the literature (Assaad, 2016). Briefly, radiolabeling of 2 mg HEDP was carried out by the addition of an appropriate volume, of SnCl 2 solution (20 mg/ml in 0.5 N HCl) followed by adjustment to pH 6-7, and the addition of 18.5 MBq freshly eluted 99m TcO 4 − in 1 ml of saline solution.…”
Section: Labeling Of Hedp With 99m Tcmentioning
confidence: 99%
“…[4][5][6][7] The precision of these imaging techniques allows healthcare professionals to identify and evaluate various ailments with accuracy. 8 However, while RPs offer remarkable accuracy in diagnosis and treatment, several usage challenges exist. 9 These include the short half-lives of certain radioisotopes, limited availability, and cost considerations.…”
Section: Introductionmentioning
confidence: 99%
“…4 5 6 7 The precision of these imaging techniques allows healthcare professionals to identify and evaluate various ailments with accuracy. 8…”
Section: Introductionmentioning
confidence: 99%