New anabolic therapies for osteoporosis

Minisola, Salvatore; Cipriani, Cristiana; Occhiuto, Marco; Pepe, Jessica

doi:10.1007/s11739-017-1719-4

Cited by 39 publications

(34 citation statements)

References 48 publications

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“…Osteoporosis is a common bone disorder worldwide with the characteristics of low bone strength, degeneration of bone tissues, decreased bone mass (Coughlan and Dockery, 2014). It is known that osteoporosis results in increased bone fragility and high risk of fracture, which affects more than 200 million people worldwide and remains to be a societal problem of health (Minisola et al, 2017;Kastner et al, 2010). As an aging-related disease, osteoporosis is more frequent in the elderly, especially among postmenopausal women (Wei et al, 2016;Wang et al, 2013;Gallagher and Levine, 2011).…”

Section: Introductionmentioning

confidence: 99%

Alteration of gut microbiota in elderly postmenopausal women with osteoporosis

et al. 2020

Preprint

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Osteoporosis is a common bone disorder worldwide and causes bone fragility and fracture. Gut microbiota colonizes the gastrointestinal tract, and is associated with bone metabolism and osteoporosis. In our study, the alteration of gut microbiota in osteoporosis and its effects on bone metabolism were investigated. A total of 36 elderly postmenopausal osteoporotic women and 12 healthy controls were recruited, and their fecal samples were collected for 16S rRNA gene sequencing of gut microbiota on Illumina MiSeq platform. The venous blood and urine samples were also collected to determine the biochemical indexes. There was no obvious difference in Alpha diversity in the experiment group and control group, while differential Beta diversity was observed. The Partial Least Squares Discriminant Analysis (PLS-DA) model and variable importance in projection (VIP) scores showed that the osteoporotic women and healthy controls had different genera of Erysipelotrichaceae , Rothia , and Eubacterium . The metabolic function prediction of gut microbiota indicated that the experiment group had 634 unique functional categories, while the control group had 13 unique functional categories. The biochemical measurement revealed that the osteoclast activity indexes including urine N-terminal telopeptides of type I collagen (NTX), serum NTX, and serum C-terminal telopeptides of type I collagen (CTX) in the experiment group were higher than those in the control group, indicating that the osteoclast activity in osteoporotic women was increased. In addition, the correlation analysis of microbial metabolism with phenotypes showed the pathways in the significant modules of magenta, red, pink, and yellow were positively correlated with urine phosphate, urine creatinine, urine creatinine, serum calcium and other biochemical indexes. Collectively, our study identified the different genera between postmenopausal osteoporotic women and healthy controls, which might be potential targets for the treatment of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Alteration of gut microbiota in elderly postmenopausal women with osteoporosis

et al. 2020

Preprint

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“…Due to aging populations, the prevalence of osteoporosis is expected to significantly increase in the future [4,5]. Osteoporosis occurs mostly in women and elderly men [6]. Studies have found that about 25 % of trabecular bone and 3 % of cortical bone in adults undergo a dynamic balancing process of osteoclastic bone resorption and osteoblastic bone formation [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin K2 on bone mineral density and serum cathepsin K in female osteoporosis patients

Gu¹,

Runlin²,

Xu³

et al. 2019

Trop. J. Pharm Res

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Purpose: To investigate the influence of vitamin K2 on bone mineral density, bone metabolism and serum tissue protease K (cathepsin K) in female patients with osteoporosis. Method: A total of 210 osteoporosis patients in Affiliated Hospital of Nanjing University of Chinese Medicine who met the inclusion criteria were selected from January 2017 to January 2018. The patients were randomly divided into vitamin K2 group, strontium renate group and blank control group (70 patients/group). Strontium ranelate group was orally given 2 g of strontium ranelate daily, while vitamin K2 group received 15 mg of Gulikang capsule 3 times a day. Bone mineral density (BMD) and serum osteocalcin (BGP), β-collagen degradation product (β-crosslaps), type I procollagen amino terminal propeptide (PINP), cathepsin K (cathe K) and TRAP were measured prior to drug treatment, and six months after surgery, using standard procedures. Results: Relative to the blank control, hip and lumbar spine density of vitamin K2 and strontium ranelate groups increased to varying degrees. Strontium ranelate group had significantly higher bone mineral density (BMD) than any other groups (p < 0.05), and also had the lowest osteoclast activity (β-crosslaps and TRAP) and the highest osteogenic activity (BGP and PINP). On the other hand, osteoclast and osteogenic activities increased significantly (p < 0.05) in the vitamin K2 group. Conclusion: Appropriate vitamin K2 treatment improves BMD in the hip and waist of women with osteoporosis by promoting osteogenic activity, and by reducing osteoclast activity and cathepsin K expression.

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“…In osteoporosis, the susceptibility to fracture gets increased which is characterized by abnormal architectural arrangement of bone tissue [3]. In a person with osteoporosis a minor bump or fall is sufficed to break the bone [4]. The most common parts that get affected by osteoporosis are the spine, hip, wrists (forearm) and shoulder [5].…”

Section: Introductionmentioning

confidence: 99%

A Review: Mechanistic Insights Into the Effect of Thyroid Disorders on Estrogen Level and Bone Mineral Density

Joshi

Bisht

Singh

2019

Int J Pharm Pharm Sci

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Thyroid hormone serves as an indispensable component for the optimum functioning of various biological systems. They curb body’s metabolism, regulates the estrogen level, regulates bone turnover, essential for skeletal development and mineralization. Within the scope of knowledge, it is intimately familiar that thyroid disorders have widespread systemic manifestations, among which in hypothyroidism, even though elevated TSH (thyroid-stimulating hormone) may reduce estrogen level which in turn stimulates osteoclasts and thus cause osteoporosis, while hyperthyroidism accelerates bone turnover. Hypothyroidism does not directly interfere with the skeletal integrity, but treatment with levothyroxine for the suppression of TSH to bring the hypothyroid patient to euthyroid state for a long haul; lead to simultaneous reduction in bone mass and in (bone mineral density) BMD. After the initial relevation of the correlation between thyroid disorders and osteoporosis in numerous studies have emphasized that both hypo and hyperthyroidism either directly or indirectly affects the bone mineral density or leads to the progression of osteoporosis. Therefore the present study is aimed and so designed to review all the possible associations between them and the impact of thyroid disorders on estrogen level and bone mineral density. The main findings of this review indicate that both excesses as well as deficiency of thyroid hormone can be potentially deleterious for bone tissue.

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New anabolic therapies for osteoporosis

Cited by 39 publications

References 48 publications

Alteration of gut microbiota in elderly postmenopausal women with osteoporosis

Alteration of gut microbiota in elderly postmenopausal women with osteoporosis

Effect of vitamin K2 on bone mineral density and serum cathepsin K in female osteoporosis patients

A Review: Mechanistic Insights Into the Effect of Thyroid Disorders on Estrogen Level and Bone Mineral Density

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