New Antibacterial Secondary Metabolites from a Marine-Derived Talaromyces sp. Strain BTBU20213036

Abstract

New polyketide-derived oligophenalenone dimers, bacillisporins K and L (1 and 2) and xanthoradone dimer rugulosin D (3), together with four known compounds, bacillisporin B (4), macrosporusone D (5), rugulosin A and penicillide (6 and 7), were isolated from the marine-derived fungus Talaromyces sp. BTBU20213036. Their structures were determined by detailed analysis of HRESIMS, 1D and 2D NMR data, and the absolute configurations were determined on the basis of calculated and experimental electronic circular dichroism (ECD). The antibacterial and antifungal activities of these compounds were tested against Gram-positive—Staphylococcus aureus, Gram-negative—Escherichia coli, and fungal strain—Candida albicans. These compounds showed potential inhibitory effects against S. aureus with minimum inhibitory concentrations ranging from 0.195 to 100 µg/mL.

Marine natural products

“…253) and oligophenalenone 790 and 791 and xanthoradone 792 dimers. 254 Culture of a Trametes strain yielded spiromeroterpenoids 793 and 794 (ref. 255) and cultures of various Trichoderma strains were the source of trichothecanes 795 – 798 , 256 α-pyrone 799 and decalin 800 , 257 sesquiterpene glycoside 801 and sorbicillinoid glycosides 802 and 803 , 258 β-carboline alkaloids 804 – 807 ( 805 and 806 , known synthetics but new NPs), 259 and polyketides 808 , 809 , 260 810 – 814 .…”

Biotechnological potential of Talaromyces sp. isolated from soil of Caatinga biome in the production of pigments with antimicrobial activity

“…The pigments are considered as secondary metabolites of Talaromyces sp. strains and are described as esters, including macrolides, linear polyesters, aromatic lactones, coumarins, phthalides and they show various biological activities, including antibacterial (Song et al 2022). The antimicrobial activity detected in Talaromyces sp.…”

New Secondary Metabolites from Marine-Derived Fungus Talaromyces minnesotensis BTBU20220184

“…In our ongoing chemical investigation of marine-derived microorganisms, new antibacterial compounds have been identified from marine-derived Talaromyces strains [19,20].…”

“…This paper focuses on the isolation, detailed structure elucidation, and antimicrobial activity evaluation of these compounds. [19,20]. Further research on a marine-derived fungus from Qinzhou Bay, Guangxi Province, China, resulted in the identification of twelve compounds, including six new compounds, talamitones A and B (1 and 2), demethyltalamitone B (3), talamiisocoumaringlycosides A and B (4 and 5), and talaminaphtholglycoside (6), along with six reported compounds, mucorisocoumarin B (7), diaportinol (8), peniisocoumarin E (9), dichlorodiaportin (10), orsellinic acid (11), and 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (12) (Figure 1), from T. minnesotensis BTBT20220184 .…”