New antibiotic pigments related to fusarubin from Fusarium solani (MART.) SACC. I. Fermentation, islation, and antimicrobial activities.

Ammar, M. S.; Gerber, Nancy N.; McDaniel, L. E.

doi:10.7164/antibiotics.32.679

Cited by 27 publications

(20 citation statements)

References 8 publications

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“…Of those tested, most have exhibited activity against grampositive bacteria, with MIC values from 2 to 500 ~tg mL (Table 3). A comparison of published MIC values for S. aureus to those of the present study showed our culture was less sensitive to compound 7 (bostrycoidin), but more sensitive to compounds 6 and 18 (anhydrofusarubin and javanicin) [ 1,5].…”

Section: Resultssupporting

confidence: 51%

Antimicrobial activity of naphthoquinones from Fusaria

1990

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Twenty-two naphthoquinone compounds isolated or derived synthetically from culture extracts of Fusarium solani and F. oxysporum were examined for antimicrobial activity. Fifteen exhibited antibiotic activity against Staphylococcus aureus, and 12 were active against Streptococcus pyogenes, but none were active at the highest rate of 128 micrograms/ml against Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Serratia marcescens, or Pseudomonas aeruginosa. Of 8 plant pathogenic bacteria tested against 11 naphthoquinones, Corynebacterium poinsettiae was inhibited by 6 compounds, and Pseudomonas viridiflava was weakly inhibited by one. Only one of a group of 6 fluorescent soil pseudomonads was inhibited by one naphthoquinone. Antifungal activity of 10 compounds against 8 fungal plant pathogens was limited to inhibition of Phytophthora parasitica by one naphthopyran.

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Section: Resultssupporting

confidence: 51%

Antimicrobial activity of naphthoquinones from Fusaria

1990

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“…Increased expression of 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase, MetE (BGLT01007) in co-cultivation with A. alternaria also suggests oxidative stress, since this protein is very highly expressed in E. coli cells exposed to oxidative stress (Hondorp and Matthews, 2004). Antibacterial compounds released by the fungi could cause oxidative stress (Ammar et al, 1979;Hellwig et al, 2002;Deshmukh et al, 2014;Soltani and Hosseyni Moghaddam, 2014). An increase of the RND (resistance nodulation division) family of efflux pumps (Rivilla et al, 1995) and the CmeABC multidrug efflux system of Campylobacter jejuni (Lin et al, 2002), which are involved in the export of a wide range of drugs.…”

Section: Genetic Features Of B Glathei Lgm14190 Possibly Involved Inmentioning

confidence: 99%

Molecular mechanisms underlying the close association between soil Burkholderia and fungi

Stopnišek¹,

Zühlke²,

Carlier³

et al. 2015

The ISME Journal

109

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Bacterial species belonging to the genus Burkholderia have been repeatedly reported to be associated with fungi but the extent and specificity of these associations in soils remain undetermined. To assess whether associations between Burkholderia and fungi are widespread in soils, we performed a co-occurrence analysis in an intercontinental soil sample collection. This revealed that Burkholderia significantly co-occurred with a wide range of fungi. To analyse the molecular basis of the interaction, we selected two model fungi frequently co-occurring with Burkholderia, Alternaria alternata and Fusarium solani, and analysed the proteome changes caused by cultivation with either fungus in the widespread soil inhabitant B. glathei, whose genome we sequenced. Co-cultivation with both fungi led to very similar changes in the B. glathei proteome. Our results indicate that B. glathei significantly benefits from the interaction, which is exemplified by a lower abundance of several starvation factors that were highly expressed in pure culture. However, co-cultivation also gave rise to stress factors, as indicated by the increased expression of multidrug efflux pumps and proteins involved in oxidative stress response. Our data suggest that the ability of Burkholderia to establish a close association with fungi mainly lies in the capacities to utilize fungalsecreted metabolites and to overcome fungal defense mechanisms. This work indicates that beneficial interactions with fungi might contribute to the survival strategy of Burkholderia species in environments with sub-optimal conditions, including acidic soils.

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“…nHexane soluble fraction was obtained only in three strains which showed mild toxicity. Antimicrobial naphthoquinones are widely distributed in plants, fungi and some animals (Riffel et al, 2002) are also reported from F. solani (Ammar et al, 1979;Baker et al, 1990). Besides naphthoquinones, F. solani is also known to produce diterpene and paclitaxel (Chakravarthi et al, 2008), and has been used alone or in combination with other chemotherapeutic agents for the treatment of variety of cancers, as well as AIDS-related Kaposi sarcoma (Brown, 2003;Croom, 1995 Means of 3 replicates.…”

Section: Resultsmentioning

confidence: 99%

“…F. solani is known to produce naphthoquinone compounds (Baker et al, 1990) including fusarubin, anhydrofusarubin, javanicin, norjavanicin, methyl etherfusarubin, marticin, isomarticin, bostrycoidia, ethyl ether-fusarubin, solaniol, nectriafusarubin and dihydrofusarubin lactone (James & Robert 1983;Kurobane et al, 1980;Tatum et al, 1985). Some naphthaquinones have antimicrobial, toxic, insecticidal and antitumor properties (Ammar et al, 1979). In our previous study, F. solani strains showed nematicidal activity against Meloidogyne javanica (Hameed et al, 2001) and antimicrobial activity against some Gram positive and negative bacteria and root rot strain of F. solani (Qureshi et al, 2003).…”

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confidence: 99%

Toxicity of <I>Fusarium solani</I> Strains on Brine Shrimp (<I>Artemia salina</I>)

Hameed¹,

Sultana²,

Ara³

et al. 2009

Zoological Research

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Discovery of anticancer drugs that must kill or disable tumor cells in the presence of normal cells without undue toxicity is an extraordinary challenge. Cytotoxicity of plant or fungal materials is considered as the presence of antitumor compounds. Brine shrimp lethality for larvae (nauplii) is used as prescreening test for the antitumor compounds. In this study, culture filtrates of eight strains of Fusarium solani isolated from seeds of various crops were tested for the toxic effect on brine shrimp. Five of the strains (TS, S-29, B-17, C-10, W-5) showed highest toxic effect and three of the strains (SR, T-9, L-25) showed low toxic activity on brine shrimp. Toxic activity reduced when culture filtrates were diluted. However, F. solani strains TS, B-17, SR, T-9 and L-25 caused more than 30% mortality at 1:10 dilution. Toxic activity was slightly reduced when the filtrates were neutralized with sodium hydroxide indicating possible role of pH of culture filtrate on toxicity. Lyophilized filtrates of these strains showed less activity as compared to un-lyophilized filtrates. n-Hexane soluble fraction was obtained only in three strains which showed mild toxicity whereas chloroform soluble fraction was obtained in negligible quantity and could not further be proceeded. Toxic effect of these strains showed variation from strain to strain. Compounds from F. solani could be exploited for the development of toxic compounds. Pakistan; 3. Agricultural Biotechnology and Phytopathology Laboratory, Department of Botany, University of Karachi, Pakistan; 4. California Department of Food and Agriculture, 3288 Meadowview Road, Sacramento, CA 95832, USA) 摘要：寻找能杀伤肿瘤细胞而对正常细胞无毒的抗癌药物极具挑战性。具有细胞毒性的植物或者真菌可能含有抗肿瘤的化合物。卤虫无节幼体的致死性可作为筛选抗肿瘤化合物的试验。本研究运用从不同农作物种子分离的 8 株镰刀菌（Fusarium solani）培养滤液来测试卤虫的细胞毒性效果。结果表明，5 株菌株（TS、S-29、B-

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New antibiotic pigments related to fusarubin from Fusarium solani (MART.) SACC. I. Fermentation, islation, and antimicrobial activities.

Cited by 27 publications

References 8 publications

Antimicrobial activity of naphthoquinones from Fusaria

Antimicrobial activity of naphthoquinones from Fusaria

Molecular mechanisms underlying the close association between soil Burkholderia and fungi

Toxicity of <I>Fusarium solani</I> Strains on Brine Shrimp (<I>Artemia salina</I>)

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