New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750

Abstract

Seven novel compounds, namely peniresorcinosides A–E (1–5), penidifarnesylin A (6), and penipyridinone A (7), together with the 11 known ones 8–17, were isolated from a culture of the marine-associated fungus Penicillium sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher’s method, 13C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (1) and B (2) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC50 values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively.

Two New Prenylated Glycine Derivatives from the Marine‐Derived Fungus Fusarium sp. TW56‐10

“…The seed broth (5 mL) was transferred into rice medium (40 g rice, 60 mL water with 2 g sea salt) in 500 mL Erlenmeyer flask. After four weeks fermentation in 28 °C, the medium was extracted with AcOEt [29] …”

Fabrication and Basic Properties of Elastomeric Staple Fiber Based on Poly(Butylene Terephthalate)-Block-(Tetramethylene Oxide) by Melt Spinning

“…The synthesis of block-copoly(ether ester) elastomers [9]; their structural characteristics [10]; and rheological [11], mechanical [12,13], fiber-forming [14], and surface properties [15] were systematically studied in the laboratory of one of us (D. Wu). The resulting know-how was transferred to Chengdu Jilun Co., which now produces different chips of poly(ether ester)s and filaments based on them.…”

“…Copoly(ether ester) fibers with high contents of soft segments show the greatest elasticity; with low contents of soft segments, the lowest. The former has strength like Lycra; the latter, ordinary PET fiber.The synthesis of block-copoly(ether ester) elastomers [9]; their structural characteristics [10]; and rheological [11], mechanical [12,13], fiber-forming [14], and surface properties [15] were systematically studied in the laboratory of one of us (D. Wu). The resulting know-how was transferred to Chengdu Jilun Co., which now produces different chips of poly(ether ester)s and filaments based on them.…”

Antiglioma Natural Products from the Marine-Associated Fungus Penicillium sp. ZZ1750

“…During the course of our ongoing research program for the discovery of novel antiglioma natural products from marine-sourced microorganisms [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], an identified fungus strain, Penicillium sp. ZZ1750 ( Table S1 ), was isolated from a marine mud sample collected from the Arabian Sea close to Karachi, Sindh, Pakistan.…”

“…ZZ1750 ( Table S1 ), was isolated from a marine mud sample collected from the Arabian Sea close to Karachi, Sindh, Pakistan. This fungus in rice medium produced twelve novel compounds, including peniresorcinosides A–E ( 13 – 17 ), penidifarnesylin A, penipyridinone A [ 17 ], ergochromes D–G ( 18 – 21 ) [ 19 ], and penipyridinone B ( 1 , Figure 1 ), an unidentified compound with a complicated structure. Interestingly, peniresorcinosides A–E were five rare glycosylated alkylresorcinols produced by the strain ZZ1750 in rice medium for a 30 day culture, while the four polyhydroxanthones of ergochromes D–G were the metabolites of this strain in rice medium for a 90 day culture.…”