New antiradical capacity assay with the use potentiometric method

Ivanova, Alla V.; Газизуллина, Е. Р.

doi:10.1016/j.aca.2018.09.025

Cited by 16 publications

(35 citation statements)

References 17 publications

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“…Earlier [44][45][46], we developed approaches and potentiometric sensor systems based on non-radical and radical oxidants, which make it possible to implement ET, HAT, and the chelating metals mechanism. High degrees of correlation with independent conventional methods, the Folin assay, the DPPH assay (inhibition of the stable radical of 2,2-diphenyl-1picrylhydrazyl), the TAS (total antioxidant status) Randox, and others [44][45][46][47][48] have been shown. The measurement results were calculated by the shift or regular change in the system potential and expressed as the integral parameter of the antioxidant capacity or the antiradical capacity, respectively.…”

Section: Genista Tinctorialmentioning

confidence: 99%

“…The antioxidant capacity is the effective concentration of K 3 [Fe(CN) 6 ] reacted with an antioxidant. The AOC expressed in universal units (mol-eq/L) and was calculated by Formulas (1) and (2) [44][45][46][47][48]. The number of equivalents in the AO molecule as a rule corresponds to the number of functional antioxidant groups involved in the electron-transfer process.…”

Section: Sensor System For Determining Antioxidant Capacity (Aoc)mentioning

confidence: 99%

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Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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A comprehensive study of a range of flavonoids and coumarins is presented in this article. The work uses an approach that evaluates the activity of these compounds by various mechanisms: the electron transfer (ET), the hydrogen atom transfer (HAT), and the mechanism of metal chelation. The studies were carried out using the methods of the cyclic voltammetry and the potentiometry. The electrochemical behavior of these compounds was studied by the method of cyclic voltammetry; the main types of voltammograms, depending on the oxidation mechanisms, were identified. Various versions of potentiometric sensor systems have been used to detect analytical signal in approaches implemented in ET, HAT and metal chelation mechanisms. The antioxidant capacity was studied by the electron-transfer mechanism. Compounds with antioxidant properties were selected; half-reaction periods for these compounds have been determined. It has been shown that electron-donating and complexing properties directly depend on the mutual arrangement of hydroxyl groups in the molecule. The antiradical ability of the compounds has been studied. It was shown that all studied compounds inhibit peroxyl radicals. Series on the change in antioxidant and antiradical properties of compounds have been compiled. There is no correlation between the results of the study of antioxidant properties obtained using sensory systems that reveal various antioxidant mechanisms. The need to use an integrated approach in the study of antioxidant properties is shown.

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Section: Genista Tinctorialmentioning

confidence: 99%

Section: Sensor System For Determining Antioxidant Capacity (Aoc)mentioning

confidence: 99%

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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“…The basis for the definition of total antiradical capacity (TAC) is a regular change of the redox potential [ 126 , 127 ]. Figure 6 a,b shows kinetic curve of the potential change (a) and the derivative of the potential dependence on time (b): 1, 0.1 M AAPH; 2, the addition of ascorbic acid (C = 0.1 mM) to 0.1 M AAPH.…”

Section: Methods To Evaluate Integrated Antioxidant Propertiesmentioning

confidence: 99%

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Ivanova

Газизуллина

2020

Molecules

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The creation and analysis of a large variety of existing methods for the evaluation of integrated antioxidant properties are quite relevant in connection with a range of biological mechanisms of the antioxidants (AO) action. In this work, the existing methods are correlated with mechanisms of antioxidant action. It is shown that the results obtained by various methods are mainly incomparable. This can be connected with the implementation of various mechanisms of antioxidant action in methods. The analysis of the literature data presented in this review indicates the difficulty of creating a universal method and the feasibility of using integrated approaches based on the use of several methods that implement and combine various mechanisms of the chemical conversion of antioxidants. This review describes methods for studying the chelating ability of antioxidants, except for methods based on electron and hydrogen atom transfer reactions, which are currently not widely covered in modern literature. With the description of each mechanism, special attention is paid to electrochemical methods, as the interaction of active oxygen metabolites of radical and non-radical nature with antioxidants has an electron/proton/donor-acceptor nature, which corresponds to the nature of electrochemical methods and suggests that they can be used to study the interaction.

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“…We are convinced that it is precisely this term and not “capacity” that does not have a certain physical meaning, so it is advisable to use it to characterize the antioxidant system. The latter is especially significant when using electrochemical monitoring methods, for example, in [39], because it is the activity that determines directly the potential of the electrode that serves as a source of analytical information.…”

Section: Methodsmentioning

confidence: 99%

Antioxidants: Terminology, Methods, and Future Considerations

2019

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Unreliable terminology and incompatible units of antioxidant activity/concentration expression lead to the failure of antioxidant clinical trials, ambiguity of conclusions about the effect of a chosen therapy in medicine and evaluation of food quality, diet, difficulties using information in monitoring the training process in sports, etc. Many different terms (antiradical activity, antioxidant activity, antioxidant capacity, antioxidant power, antioxidant ability) and methods: Trolox equivalent capacity assay (TEAC), Ferric Reducing Antioxidant Power assay (FRAP), Cupric Reducing Antioxidant Capacity assay (CUPRAC), antioxidative activity assay (ABTS), the oxygen radical absorbance capacity (ORAC), and different options of electrochemical ones) proposed for the determination of antioxidants are described. Possible approaches to the development of this field of science and practice are considered.

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New antiradical capacity assay with the use potentiometric method

Cited by 16 publications

References 17 publications

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Antioxidants: Terminology, Methods, and Future Considerations

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