Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Abstract

The creation and analysis of a large variety of existing methods for the evaluation of integrated antioxidant properties are quite relevant in connection with a range of biological mechanisms of the antioxidants (AO) action. In this work, the existing methods are correlated with mechanisms of antioxidant action. It is shown that the results obtained by various methods are mainly incomparable. This can be connected with the implementation of various mechanisms of antioxidant action in methods. The analysis of the literature data presented in this review indicates the difficulty of creating a universal method and the feasibility of using integrated approaches based on the use of several methods that implement and combine various mechanisms of the chemical conversion of antioxidants. This review describes methods for studying the chelating ability of antioxidants, except for methods based on electron and hydrogen atom transfer reactions, which are currently not widely covered in modern literature. With the description of each mechanism, special attention is paid to electrochemical methods, as the interaction of active oxygen metabolites of radical and non-radical nature with antioxidants has an electron/proton/donor-acceptor nature, which corresponds to the nature of electrochemical methods and suggests that they can be used to study the interaction.

Antiradical Properties of N-Oxide Surfactants—Two in One

“…The two mechanisms were previously considered in the context of the antiradical activity of phenolic compounds and radical activity of insecticides in the soil environment [ 32 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy

“…Conversely, p -coumaric acid ( 9 ), p -anisic acid ( 10 ) and caffeic acid ( 11 ) are known to possess marked scavenging and chelating antioxidant properties [ 62 , 63 , 64 ]. These activities could be due to the presence of multiple functional groups, such as hydroxy or methoxy substituents with a carboxyl group as explained by Ivanova et al [ 65 ]. Based on this evidence, the contribution of these compounds to the antioxidant activity of D. sericea extract can be hypothesized: this bioactivity could be a result of the subtle interactions of these phytochemicals, although the involvement of the entire phytocomplex cannot be excluded.…”

Coumarin Derivatives in Inflammatory Bowel Disease

“…A recent review reported that different antioxidant compounds act by six general mechanisms: inhibiting free radical production by activated oxygen metabolites, changing the structural organization of free radical, producing a local decrease of oxygen concentration, interacting with organic radicals, chelating metal ions, and converting peroxides to stable and inactive products [ 28 ]. These processes reduce the availability of free radical species, improving the response against oxidative stress, which are the main properties of the coumarin derivatives with intestinal anti-inflammatory activity.…”