New antitumor sesquiterpenoids from Santalum album of Indian origin

Kim, Tae Hoon; Ito, Hideyuki; Hatano, Tsutomu; Takayasu, Junko; Tokuda, Harukuni; Nishino, Hoyoku; Machiguchi, Takahisa; Yoshida, Takashi

doi:10.1016/j.tet.2006.04.072

Cited by 52 publications

(31 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…220.35 A, [11] AC [9] 101 a-Acorenol h 28296-85-7 222.37 S, [16] AC [9] 102 epi-a-Acorenol h 741260-10-6 222.37 S, [16] AC [9] 103 b-Acorenol h 28400-11-5 222.37 S, [16] AC [9] 104 epi-b-Acorenol h 741260-11-7 222.37 S, [16] AC [9] 105 Campherenol h 18530-03-5 b 222.37 S, [29] AC, [9] I [33] [46] S, [37] AC, [9] I [44] A, [13] S, [29] I [47] 114 b-Santaldiol A, [13] S, [29] I [47] 115 9(E)-11-Hydroxy-a-santalol AC, [14] S [29] *, I [33] * 120 (E)-6,13-Dihydroxybisabola-2,10-diene A, [27] S [29] *, I [44] * 122 (6R,7S,10Z)-6,13-Dihydroxybisabola-2,10-diene S, [29] AC, [9] I [33] A, [28] S [29] *, AC [9] *, I [33] 141…”

Section: -02-7mentioning

confidence: 99%

Phytochemistry of the heartwood from fragrant Santalum species: a review

Baldovini

Delasalle

Joulain³

2010

Flavour & Fragrance J

105

View full text Add to dashboard Cite

A comprehensive review is presented on the constituents of the heartwood from fragrant sandalwood species, including Santalum album, S. spicatum and S. austrocaledonicum, which are important raw materials in the fragrance industry, and S. insulare, a closely related species. Analytical aspects are discussed in detail, both on qualitative and quantitative standpoints, and sensory properties are also reviewed. It is shown that more than 230 constituents have been identified so far in the heartwood of these sandalwood species. These components belong to many different chemical classes and are mainly terpenoids, but some other families are also represented.

show abstract

Section: -02-7mentioning

confidence: 99%

Phytochemistry of the heartwood from fragrant Santalum species: a review

Baldovini

Delasalle

Joulain³

2010

Flavour & Fragrance J

105

View full text Add to dashboard Cite

show abstract

“…[25] www.wjpps.com however, elicited higher ratings of attentiveness and mood than did Sandalwood oil or the placebo. Correlation analyses revealed that these effects are mainly due to perceived odor quality.…”

Section: Effect Of Sandalwood Oil and Treatment Of Mental Disordersmentioning

confidence: 86%

Recent Developments in Pharmaceutical and Therapeutic Applications of Sandalwood Oil

Soundararajan¹

2017

WJPPS

View full text Add to dashboard Cite

Santalum album L is commercially known as the East Indian sandalwood. The average yield of oil ranges from 2-6% w/w of heartwood content. Santalum album L. has been widely used in folk medicine for various ailments like common colds, bronchitis, skin disorders, heart ailments, infection of the urinary tract and other diseases. Since ancient times, sandalwood oil is recognized for its medicinal value and very interesting and powerful natural plant source.Recent pharmacological investigations reveal that the therapeutic potentials associated with Indian sandalwood oil and its constituents such as the role of santalols in combating cancer, viral diseases, as well as neuroleptic, skin nourishing agent and as dietary factors promise future healthcare applications. Sandalwood has been used in traditional medicine system for treating digestive complications arising from diarrhea, nausea, colic and gastritis, muscle relaxant and coolant. It has long been valued for treating these types of genito-urinary infections. Its use in treatment of skin problems is legendary. In the realm of mental and emotional therapeutics, sandalwood is used for treating stress, depression, stress anxiety and nervous tension as it is both a sedative and tonic. Antiviral activity of sandalwood oil against herpes simplex virus, anti-cancer activities, treatment of various eye infections as herbal eye-drop preparation, blood pressure and selfrated arousal like alertness, attentiveness, calmness, mood, relaxation and vigor in humans have been added to latest report. The aim of this review is to comprehend and put forth, available information on the therapeutic uses of Indian sandalwood oil from pharmacological point of view for future directions in clinical applications.

show abstract

“…Other hydrocarbons such as α-santalene, β-santalene, α-bergamotene and epi-β-santalene are also present in the oil as well as α-curcumene, β-curcumene, γ-curcumene, β-bisabolene and α-bisabolol are also reported in heartwood [6]. New antitumor sesquiterpenoid from S. album L. also reported in methanolic extract of heartwood [7].From Indian origin heartwood of S. album, some new bisabolane and santalane type of sesquiterpenoids along with (+) α-nuciferol, (+) citronellol and geraniol were isolated [8].More oil constituents including santalone, 3-dien-1-yl methyl ketone, 4-methylcyclohexa-1, (E)-5-(2, 3-dimethyl-3-nortricyclyl)-pent-3-en-2-one and 5, 6-dimethyl-5-norbornen-exo-2-olwere identified [9].Indian sandalwood oil also confirmed two new sesquiterpene aldehydes as Cyclosantalal and epicyclosantalal [10]. The heartwood oil of S. albumL.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation and in Vitro Antimicrobial Screening of Santalum Album Seeds Extracts

Vadnere¹,

Usman²,

Lodhi³

et al. 2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Aim of the present study was to perform phytochemical evaluation and antimicrobial screening of petroleum ether and ethanol extracts of Santalum album seeds.Methods: Petroleum ether and ethanol extracts were screened for the presence of chemical constituents. Petroleum ether extract was investigated detail by using chromatographic and spectroscopic methods. In vitro antimicrobial activity of both extracts were investigated using disc diffusion method on two gram-positive bacteria, Bacillus subtilis, Staphylococcus aureus, gram-negative Pseudomonas aeruginosa, Escherichia coli and fungus Candida albicans.Results: Santalbic acid was identified in petroleum ether extract and content determined by HPTLC was 4.7%w/w. It was seen that petroleum ether extract have MIC value for B. subtilis, P. aeruginosa, E. coli and C. albicans were 78.125 µg/ml, 19.331 µg/ml, 625 µg/ml and 39.062 µg/ml respectively while MBC was 39.062 µg/ml, 4.882 µg/ml, 312.5 µg/mland 9.765 µg/ml, respectively. Petroleum ether extract showed MIC and MBC values for S. aureus was similaras 156.25µg/ml. So, the petroleum ether extract showed significant antimicrobial activity against both grams positive, gram negative and fungal strain. Conclusion:The results of present investigations were indicative of possible high potency of petroleum ether extract due to santalbic acid which could serve as chemotherapeutic agent.

show abstract

New antitumor sesquiterpenoids from Santalum album of Indian origin

Cited by 52 publications

References 43 publications

Phytochemistry of the heartwood from fragrant Santalum species: a review

Phytochemistry of the heartwood from fragrant Santalum species: a review

Recent Developments in Pharmaceutical and Therapeutic Applications of Sandalwood Oil

Phytochemical Investigation and in Vitro Antimicrobial Screening of Santalum Album Seeds Extracts

Contact Info

Product

Resources

About