New Applications in Photodynamic Therapy Introduction

Levy, Julia G.; Obochi, Modestus

doi:10.1111/j.1751-1097.1996.tb01828.x

Cited by 85 publications

(60 citation statements)

References 14 publications

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“…Photodynamic therapy (PDT) is a promising new modality for the treatment of a variety of cancers as well as some dermatological and ophthalmic diseases 1,[20][21][22][23][24] The main advantage of PDT over conventional cancer chemotherapy is the capability to localize the treatment, by using selective light exposure to the tumor site. 1, 25 Typical PDT treatment involves systemic administration of a photosensitizer drug, followed by localized light exposure at the tumor site, using visible or near-infrared (NIR) light.…”

Section: Introductionmentioning

confidence: 99%

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

et al. 2007

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A carrier free method for delivery of a hydrophobic drug in its pure form, using nanocrystals (nano sized crystals) is proposed. To demonstrate this technique, nanocrystals of a hydrophobic photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide (HPPH), have been synthesized using re-precipitation method. The resulting drug nanocrystals were monodispersed and stable in aqueous dispersion, without the necessity of an additional stabilizer (surfactant). As shown by confocal microscopy, these pure drug nanocrystals were taken-up by the cancer cells with high avidity. Though the fluorescence and photodynamic activity of the drug were substantially quenched in the form of nanocrystals in aqueous suspension, both these characteristics were recovered under in vitro and in vivo conditions. This recovery of drug activity and fluorescence is possibly due to the interaction of nanocrystals with serum albumin, resulting in conversion of the drug nanocrystals into the molecular form. This was confirmed by demonstrating similar recovery in presence of Fetal Bovine Serum (FBS) or Bovine Serum Albumin (BSA). Under similar treatment conditions, the HPPH in nanocrystal form or in 1% Tween 80/water formulation showed comparable in vitro and in vivo efficacy.

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Section: Introductionmentioning

confidence: 99%

New Method for Delivering a Hydrophobic Drug for Photodynamic Therapy Using Pure Nanocrystal Form of the Drug

et al. 2007

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“…Photodynamic therapy (PDT) mediated by Photofrin has recently been approved as a therapeutic modality for specific types of malignant tumours (Levy, 1996). This breakthrough further stimulates research efforts aimed at developing more effective phototherapeutic protocols, as well as at broadening the scope of PDT and overcoming its present limitations.…”

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confidence: 99%

High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

et al. 1999

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Summary Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 µmol kg -1 ) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 µmol kg -1 . Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes.

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“…EPN, Carlos Andrade Marín Hospital, and Gonzalo Gonzalez Dermatological Hospital are executing this international project to diagnose and treat superficial basal cell carcinoma (CBC) with mediated PDT. This technique destroys tumor tissues by using a specific wavelength in the presence of oxygen to activate a photosensitizer [7,8].…”

Section: The Importance Of Collaborationmentioning

confidence: 99%