New approach in the treatment of ophthalmic neovascular disorders: using fusion protein aflibercept

Georgiev, Kaloyan; Georgiev, Dobrin; Georgiev, Dobrin S.

doi:10.14748/bmr.v25.1048

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Приложението му върху мишки с индуцирана ендометриоза показва инхибиране на ендометриозните лезии, като намалява клетъчната пролиферация и стимулира апоптозата (80). Други възможности за повлияване на VEGF е чрез използване на фузионния протеин aflibercept (81).…”

Section: нехормонални терапевтични възможностиunclassified

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

Spasova

Karamisheva

Staneva

et al. 2019

ahp

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UMBALSM "Pirogov" РЕЗЮМЕ Ендометриозата е хронично естроген-зависимо заболяване, което се характеризира с развитие на ендометриална тъкан извън маточната кухина. В световен мащаб засяга около 10% от жените. Заболяването може да причини дисменорея, хронична тазова болка, диспареуния и инфертилитет. Медикаментозното лечение играе ключова роля в контрола на заболяването. В повечето случаи е наложително лекарствената терапия да бъде комбинирана с хирургична, за да бъде постигнато пълно излекуване. Подходът при избор на подходящо медикаментозно лечение трябва да бъде индивидуализиран, като бъде съобразен с тежестта на ендометриозата, ефикасността на лекарството, страничните му ефекти, желанието на пациентката, възрастта ѝ и репродуктивните ѝ планове. Голяма част от използваните днес лекарства за лечение на ендометриоза целят потискане на овариалната функция. Най-често прилаганите и показващи най-добри резултати са комбинираните орални контрацептиви, аналозите на гонадотропин-освобождаващия хормон и прогестините. Освен тези утвърдени терапии, съвременното лечение включва и нови хормонално и нехормонално-базирани терапевтични подходи, които модулират различни патогенетични механизми. В този обзор ще бъдат разгледани настоящите терапевтични опции-както класическите, така и по-новите, все още неодобрени медикаменти за лечение на ендометриоза.

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Section: нехормонални терапевтични възможностиunclassified

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

Spasova

Karamisheva

Staneva

et al. 2019

ahp

View full text Add to dashboard Cite

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“…25 Among the recent contributions to the study of the problem, we should single out that by the Bulgarian scholar Pavel Georgiev in 2001. 26 Georgiev revisited the argumentation in the earlier literature, discussed the use and character of the patriarchal epirriptarion, and discovered an instance of Byzantine imperial coronation ceremony that fits more closely than any other with what our sources succinctly indicated about that of 913. This ceremony, described in an anonymous account of the enthronement of Manuel II Palaiologos (1391-1425) as senior emperor in 1391, constituted a blessing and confirmation (apokatastasis) of an emperor who had already been crowned on a previous occasion.…”

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confidence: 91%

The Crown and the Veil: Titles, Spiritual Kinship, and Diplomacy in Tenth‐Century Bulgaro–Byzantine Relations

Mladjov

2015

History Compass

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When it comes to diplomatic relations, the phrase "too close for comfort" perfectly describes the relationship between the medieval Byzantine and Bulgarian states in the Balkan peninsula. In the early 10th century, shortly after Bulgaria's conversion to the Eastern rite of Christianity, the two states engaged in a bloody and lengthy conf lict over not just territory and wealth but also over the now exacerbated issues of diplomatic equality and prestige. Marching on Constantinople, the Bulgarian monarch Simeon I demanded the imperial title itself and was partly accommodated by the Ecumenical patriarch Nicholas I in an idiosyncratic ceremony that has caused much debate among Byzantinists and Slavicists. This study explores the main features of the historiographical debate and attempts to find the correct answers in the testimony of the relevant sources. And while the incident under investigation might appear self-contained, it lies at the heart of a major preoccupation of Byzantine diplomacy: Byzantium's monopoly on the political heritage of Rome and the Roman imperial title. Correctly interpreted and compared to Byzantium's diplomatic relations with the Frankish ruler Charlemagne, Simeon's recognition as a non-Roman emperor and peer of his Byzantine counterpart in 913 suggests a pattern of grudging and incomplete accommodation designed to guarantee both the safety and the identity of the Byzantine Empire.August 913. The Bulgarian ruler Simeon I (893-927) reached Constantinople with a large army and proceeded to blockade the peninsular city by land, digging a ditch from the Blachernai Palace on the Golden Horn in the north to the Golden Gate on the Sea of Marmara in the south. Allegedly surprised by the strength of the defenses, he retired to Hebdomon, southwest of Constantinople, and made overtures for peace. The regency for the underage Byzantine emperor Constantine VII (913-958) readily accepted the proposal and brought in two of Simeon's sons to dine with the emperor at the Blachernai. At this point, the leading regent, Patriarch Nicholas I Mystikos (901)(902)(903)(904)(905)(906)(907)(912)(913)(914)(915)(916)(917)(918)(919)(920)(921)(922)(923)(924)(925), went out to Simeon; Simeon bowed his head before the patriarch, and the latter, having read out a prayer, placed on Simeon's head his own veil or cowl (epirriptarion) instead of an imperial crown (stemma).This far, our narrative follows the Chronicle of the Logothete and the early chroniclers who followed his mid-tenth-century account. 1 A later and largely derivative set of accounts, first represented by John Skylitzes (late eleventh century), related the same general story, but altered some of the details, bringing the Bulgarian monarch himself into the city for the banquet at the Blachernai after an exchange of suitable hostages, omitting any going out by the patriarch, calling Simeon a barbarian, and using a different, more generic, term for the crown (stephanos). 2 The two narrative traditions end the same way: laden with gifts, Simeon and his sons returne...

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New approach in the treatment of ophthalmic neovascular disorders: using fusion protein aflibercept

Abstract: The aim of this review is to appraise the usage of a newly approved anti-vascular endothelial growth factor (anti-VEGF) fu-

Cited by 2 publications

References 21 publications

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control

The Crown and the Veil: Titles, Spiritual Kinship, and Diplomacy in Tenth‐Century Bulgaro–Byzantine Relations

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