New approach to metrology in nanotechnology

Maksimov, S. K.; Maksimov, K. S.

doi:10.1134/s1063785010100196

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Joint use of the methods suggested in this paper and developed computer methods of SEM image processing provides the habit determination and the notice in this paragraph doesn't disprove the suggested methods of habit determination but only specifies practice of their use [4,29,30].…”

Section: a Focusing Plane Of The Parallel Beam And Initial Focusingmentioning

confidence: 89%

“…3, therefore yields of recoil electrons generated both the beams are also equal (Figure 2(A)). If to superpose an intensity profile, corresponding to the parallel beam, over an intensity profile, conforming to the convergence beam and a focus on some cross-section of an object, then these profiles cross at a point where the focusing plane of the convergence beam intersects the intensity profile also of this beam (Figure 2(B)) [29]. If to subtract an intensity profile corresponding to the parallel beam from a profile conforming to a convergent beam, the extrema and zeros of the differential curves observed in the vicinity of the same "crossing" point.…”

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

“…Following the sequence of operations allows transforming an intensity distribution in an object image into its 3D image in the real space (in the object space) that reflects to true sizes and a habit of objects and corresponds to it in a maximally possible degree [4,29,30]: 1) To focus a convergent beam on ZOHP.…”

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

“…Development of nanotechnologies and overcoming of some already existing problem (primarily in the pharmacology) demand new revolutionary in essence solutions. Possible solution of the problem of the habit particle determinations in condition of their mass production is suggested in [29] and it may be assumed as a basis in solution of the outgoing inspection problem as a whole.…”

Section: Regularities Of Sem Image Formation and Possibility Of Sem Umentioning

confidence: 99%

“…Safety guarantee in mass production of nanoparticles is possible only if the structure and habit are under control, and both these kind of control are time-consuming. Habit inspection demands use of at least 2 micrographs and their further coprocessing [4,29,30]. Structure inspection founded on the use of electron diffraction patterns reflecting different projections [31].…”

Section: General Principles Of Organization Of Outgoing Production Inmentioning

confidence: 99%

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As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

Maksimov¹,

Maksimov²,

Soukhov³

2011

JBNB

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Nanoparticles provide great advantages but also great risks. Risks associating with nanoparticles are the problem of all technologies, but they increase in many times in nanotechnologies. Adequate methods of outgoing production inspection are necessary to solve the problem of risks, and the inspection must be based on the safety standard. Existing safety standard results from a principle of “maximum permissible concentrations or MPC”. This principle is not applicable to nanoparticles, but a safety standard reflecting risks inherent in nanoparticles doesn’t exist. Essence of the risks is illustrated by the example from pharmacology, since its safety assurance is conceptually based on MPC and it has already come against this problem. Possible formula of safety standard for nanoparticles is reflected in many publications, but conventional inspection methods cannot provide its realization, and this gap is an obstacle to assumption of similar formulas. Therefore the development of nanoparticle industry as a whole (also development of the pharmacology in particular) is impossible without the creation of an adequate inspection method. There are suggested new inspection methods founded on the new physical principle and satisfying to the adequate safety standard for nanoparticles. These methods demonstrate that creation of the adequate safety standard and the outgoing production inspection in a large-scale manufacturing of nanoparticles are the solvable problems. However there is a great distance between the physical principle and its hardware realization, and a transition from the principle to the hardware demands great intellectual and material costs. Therefore it is desirable to call attention of the public at large to the necessity of urgent expansions of investigations associated with outgoing inspections in nanoparticles technologies. It is necessary also to attract attention, first, of representatives of state structures controlling approvals of the adequate safety standard to this problem, since it is impossible to compel producers providing the safety without the similar standard, and, second, of leaders of pharmacological industry, since their industry already entered into the nanotechnology era, and they have taken an interest in a forthcoming development of inspection methods

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Section: a Focusing Plane Of The Parallel Beam And Initial Focusingmentioning

confidence: 89%

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

Section: Regularities Of Sem Image Formation and Possibility Of Sem Umentioning

confidence: 99%

Section: General Principles Of Organization Of Outgoing Production Inmentioning

confidence: 99%

See 3 more Smart Citations

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

Maksimov¹,

Maksimov²,

Soukhov³

2011

JBNB

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Problem of safety in nanoparticle mass production and its solution by means of advanced scanning electron microscopy

Maksimov

2011

J. Phys.: Conf. Ser.

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Safety in large-scale manufacturing of nanoparticles for bio-medical use

Serguei¹,

Nikolai²,

Kirill³

2012

Emerging Materials Research

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Nanoparticles offer significant advantages but also great risks. Risks associated with nanoparticles are problems faced by all technologies, but they increase in many folds in nanotechnologies. Adequate methods for real-time production inspection are necessary to solve the problem of risks. Existing safety standards result from a principle of ‘maximum permissible concentrations or MPC’. This principle is not applicable to nanoparticles, but a safety standard reflecting risks inherent in nanoparticles does not exist. Possible approaches for safety standards of nanoparticles are reflected in many publications, but conventional inspection methods cannot provide its realization and this gap is an obstacle to assumption of similar solutions. Therefore, the development of nanoparticle industry as a whole (also development of the pharmacology industry in particular) is impossible without the creation of an adequate inspection method. There are newly suggested inspection methods that have been based on new physical principles and are satisfying to meet the adequate safety standards for handling nanoparticles. These methods demonstrate that the creation of acceptable safety standards and the real-time production inspection in large-scale manufacturing of nanoparticles are solvable problems. However, there is a large gap between the physical principles and its actual implementation and a transition from the principle to the hardware demands significant intellectual and material costs. Therefore, it is desirable to call the attention of the public at large to the necessity of urgent expansion of investigations associated with real time inspections in nanoparticle technologies.

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New approach to metrology in nanotechnology

Cited by 4 publications

References 6 publications

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

Problem of safety in nanoparticle mass production and its solution by means of advanced scanning electron microscopy

Safety in large-scale manufacturing of nanoparticles for bio-medical use

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