New Approaches for the Discovery of Pharmacologically-Active Natural Compounds

Medina-Franco, José L.

doi:10.3390/biom9030115

Cited by 10 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, because of limitations regarding the many side effects that impair quality of daily life, cancer drug resistance, rapid increase in the percentage of cancer mortality and numerous new cases diagnosed, scientists are driven towards the development of new therapeutic agents, with fewer or no side effects, to be used as monotherapy or together with current available treatment. To this end, natural products and, in particular, those found in abundance in nature or are easy to cultivate, consist a new area of research, since most of the times the cost of the raw material is affordable and the side effects are usually minimized [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

et al. 2022

View full text Add to dashboard Cite

Rosmarinus officinalis is a well-studied plant, known for its therapeutic properties. However, its biological activity against several diseases is not known in detail. The aim of this study is to present new data regarding the cytotoxic activity of a hydroethanolic extract of Rosmarinus officinalis on glioblastoma (A172) and rhabdomyosarcoma (TE671) cancer cell lines. The chemical composition of the extract is evaluated using liquid chromatography combined with time-of-flight mass spectrometry, alongside its total phenolic content and antioxidant activity. The extract showed a promising time- and dose-dependent cytotoxic activity against both cell lines. The lowest IC50 values for both cell lines were calculated at 72 h after treatment and correspond to 0.249 ± 1.09 mg/mL for TE671 cell line and 0.577 ± 0.98 mg/mL for A172 cell line. The extract presented high phenolic content, equal to 35.65 ± 0.03 mg GAE/g of dry material as well as a strong antioxidant activity. The IC50 values for the antioxidant assays were estimated at 12.8 ± 2.7 μg/mL (DPPH assay) and 6.98 ± 1.9 μg/mL (ABTS assay). The compound detected in abundance was carnosol, a phenolic diterpene, followed by the polyphenol rosmarinic acid, while the presence of phenolic compounds such as rhamnetin glucoside, hesperidin, cirsimaritin was notable. These preliminary results suggest that R. officinalis is a potential, alternative source of bioactive compounds to further examine for abilities against glioblastoma and rhabdomyosarcoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Bioactive natural compounds, including phytochemicals, such as polyphenols and flavonoids, vitamins, and other micronutrients, are obtained from plants, fungi, and bacteria, and other living organisms. Some are present in our food, herbs, and spices, while others are extracted from non-food sources that we would not normally obtain otherwise [ 12 ]. Bioactive natural products also form the basis for many types of complementary and alternative medicines (CAM), an umbrella term that is used to describe medical treatments and practices that are not a part of standard medical care but rather used alongside or potentially instead of it to facilitate healing, prevent disease recurrence, or alleviate adverse side effects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening

Hackman

Collins

et al. 2020

Cancers

View full text Add to dashboard Cite

Natural products have been used for centuries to treat various human ailments. In recent decades, multi-drug combinations that utilize natural products to synergistically enhance the therapeutic effects of cancer drugs have been identified and have shown success in improving treatment outcomes. While drug synergy research is a burgeoning field, there are disagreements on the definitions and mathematical parameters that prevent the standardization and proper usage of the terms synergy, antagonism, and additivity. This contributes to the relatively small amount of data on the antagonistic effects of natural products on cancer drugs that can diminish their therapeutic efficacy and prevent cancer regression. The ability of natural products to potentially degrade or reverse the molecular activity of cancer therapeutics represents an important but highly under-emphasized area of research that is often overlooked in both pre-clinical and clinical studies. This review aims to evaluate the body of work surrounding the antagonistic interactions between natural products and cancer therapeutics and highlight applications for high-throughput screening (HTS) and deep learning techniques for the identification of natural products that antagonize cancer drug efficacy.

show abstract

“…It is well known that the heath-related benefits are somehow associated with their structural uniqueness, diversity, and complexity, as compared to other drugs from different sources [4,5]. Chemical informatics (also termed in the literature chem(i)oinformatics) is increasingly contributing to drug discovery at different levels [6][7][8]. For instance, a key contribution of this research discipline is designing, building, and curating compound databases.…”

Section: Introductionmentioning

confidence: 99%

<strong></strong>LANaPD: Towards a Unified Latin America Natural Products Database

Medina-Franco¹

2020

Preprint

View full text Add to dashboard Cite

Around the World, the number of compound databases of natural products in the public domain is rising. This is in line with the increasing synergistic combination of natural product research and chemoinformatics. Towards this global endeavor, countries in Latin America are assembling, curating, and analyzing the contents and diversity of natural products available in their geographical regions. In this manuscript we collect and analyze the efforts that countries in Latin America have made so far to build natural product databases. We further encourage the scientific community in particular in Latin America, to continue their efforts to building quality natural product databases and, whenever possible, to make them publicly accessible. It is proposed that all compound collections could be assembled into a unified resource called LANaPD: Latin America Natural Products Database. Opportunities and challenges to build, distribute, and maintain LANaPD are also discussed

show abstract

New Approaches for the Discovery of Pharmacologically-Active Natural Compounds

Abstract: Natural products continue to be a major source of active compounds [...]

Cited by 10 publications

References 16 publications

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening

<strong></strong>LANaPD: Towards a Unified Latin America Natural Products Database

Contact Info

Product

Resources

About