New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture

Abstract

The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of Taraxacum officinale tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that T. officinale could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress.

The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District

“…and others [ 68 ], high contents of chlorogenic acid (1.84%) and rutin (1.46%) were found in the ethanol extract of Arctium lappa leaves, as well as significant concentrations of phytol, lupeol, and amyrin. When studying the antioxidant potential of Taraxacum officinale tincture, Epure A. and others [ 69 ] identified chicoric acid in the highest quantity in the polyphenolic composition, but other phenolic acids (protocatechuic, vanillic, syringic, and ferulic acids) were also present, along with flavonoids (rutin, quercitrin, luteolin, and apigenin).…”

Tea film formation in artificial tap water

“…5 While the total amount of polyphenols was considerably higher in rooibos than in green and black tea, 51 rooibos is known to sometimes lack the polyphenol rutin. 52,53 Additionally in rooibos, the polyphenols catechin and theaflavin have concentrations an order of magnitude lower than in green or black tea. 53…”

The development of nanocarriers for natural products

“…Flavonoids, widely found in plants, exhibit a broad spectrum of pharmacological activities. For example, flavonoids, such as quercetin, fisetin, and luteolin, extensively used to develop NDDS, are abundantly available and easily obtainable from tea, grapes, and dandelions (Epure et al, 2023; Naoi et al, 2019; Terao, 2023). Furthermore, extensive reports have shown the diverse pharmacological activities of these compounds, including antioxidant, anti‐inflammatory, antitumor, and antibacterial properties and lipid‐lowering effects.…”