New aromatase inhibitors for breast cancer

doi:10.1136/dtb.1997.35755

Cited by 6 publications

(1 citation statement)

References 8 publications

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“…Neoadjuvant endocrine therapy models [24] Chemotherapy is more effective than endocrine therapy at shrinking the tumor.…”

Section: / Murray/2006mentioning

confidence: 99%

Toward a Value-Based Therapy Recommendation Model

Liu,

Xiao

2023

Healthcare

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Patient value is an important factor in clinical decision making, but conventionally, it is not incorporated in the decision processes. Clinical decision making has some clinical guidelines as a reference. There are very few value-based clinical guidelines, but knowledge about how values affect decision making is mentioned in some scattered studies in the literature. We use a literature review method to extract evidence and integrate it as part of the decision-making model. In this paper, a value-based therapy recommendation comprehensive model is proposed. A literature analysis is conducted to collect value-based evidence. The patients’ values are defined and classified with fine granularity. Categorized values and candidate therapies are used in combination as filtering keywords to build this literature database. The literature analysis method generates a literature database used as a source of arguments for influencing decision making based on values. Then, a formalism model is put forward to integrate the value-based evidence with clinical evidence, and the literature databases and clinical guidelines are collected and analyzed to populate the evidence repository. During the decision-making processes, the evidence repository is utilized to match patients’ clinical information and values. Decision-makers can dynamically adjust the relative importance of the two pieces of evidence to obtain a treatment plan that is more suitable for the patient. A prototype system was implemented using a case study for breast cancer and validated for feasibility and effectiveness through controlled experiments.

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“…Neoadjuvant endocrine therapy models [24] Chemotherapy is more effective than endocrine therapy at shrinking the tumor.…”

Section: / Murray/2006mentioning

confidence: 99%

Toward a Value-Based Therapy Recommendation Model

Liu,

Xiao

2023

Healthcare

View full text Add to dashboard Cite

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Progress in endocrine therapy for breast carcinoma

Hortobágyi

1998

Cancer

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In the endocrine therapy of breast cancer, there are two kinds of drugs which are commonly used, tamoxi-fen and toremifene. Tamoxifen had been approved by the U.S. Food and Drug Administration as a kind of selective estrogen receptor modulators as early as 1977. It was used in the treatment of advanced breast cancer with hormone receptor positive, nevertheless as the first generation of selective estrogen receptor modula-tors, TAM produced antagonistic action of estrogen in breast tissue. Meanwhile, estrogenic activity was also produced in the uterus and bone, thus caused other adverse events like genital lesions (for example, the increasing risk of endometrial cancer) at the same time while treating breast cancer. Toremifene was a kind of estrogen receptor regulator which was approved by the FDA for the treatment of breast cancer after TAM. It had been used in the clinical adjuvant therapy on breast cancer since 1995. Recently, a number of domestic and foreign studies have discussed the similar efficacy and adverse reactions of TOR and TAM in the treatment of breast cancer in various stages. This article will summarize relevant literature and data from four aspects, the efficacy, safety, quality of life and economic benefits, and to discuss the clinical progress of toremifene and tamoxifen in endocrine therapy for breast cancer. Abstract Researches on the breast cancer pathogenesis have been greatly progressed within the past few decades, so does the immunohistochemical classification of breast cancer. Recent clinical trials and studies have shown that endocrine therapy has become a clear target treatment with confirmed efficacy of breast cancer. In the drug selection of endocrine therapy for breast cancer, tamoxifen and toremifene have been approved by the U.S. Food and Drug Administration (FDA) successively on the treatment of peri-menopausal breast cancer patients with positive hormone receptor. A number of domestic and foreign researches have been done in comparison of using toremifene and tamoxifen alone, or both in the endocrine therapy for breast cancer; however results and conclusions vary among different studies. This article will mainly focus on reviewing literatures of this field from four aspects, the efficacy, safety, quality of life and economic benefits, and discussing the clinical progress of toremifene and tamoxifen in endocrine therapy for breast cancer.

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