New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals

Ramadhan, Rico; Phuwapraisirisan, Preecha

doi:10.1016/j.bmcl.2015.08.069

Cited by 49 publications

(33 citation statements)

References 17 publications

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“…Acarbose was used as a standard control and the experiment was performed in triplicate. [3] 3. RESULTS AND DISCUSSION Compound 5 was isolated as a colorless oil and its molecular formula was determined as C10H14O2 through its pseudomolecular ion peak at m/z 165.0970 [M-H]in the HR-ESI-MS spectrum.…”

Section: α-Glucosidase Inhibition Assaymentioning

confidence: 99%

“…Base on above evidences and comparison the NMR data of 8 with those reported in the literature, [4] the chemical structure of this compound was determined as sekikaic acid. [3] Of tested compounds, 8 displayed slightly potent activity with IC50 values in 136.62 μg/mL, compared with the control acarbose IC50 93.63 μg/mL. The concentration of these compounds for 50 % inhibition of α-glucosidase activity (IC50) were summarized in table 3.…”

Section: α-Glucosidase Inhibition Assaymentioning

confidence: 99%

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Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

Linh¹,

Danova

Truong

et al. 2020

Vietnam Journal of Chemistry

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From the chloroform extract of the lichen Ramalina peruviana Ach. (Ramalinaceae), collected at Cau Dat farm, Lam Dong province, Vietnam, eight organic compounds had been isolated: nonadecan-1-ol (1); nonadecenoic acid (2); (+)-(12R)-usnic acid (3); three monophenolic compounds-rhizonic acid (4), divarinolmonomethylether (5) and divaricatinic acid (6); and two depsides-decarboxy-2'-O-methyldivaricatic acid (7) and sekikaic acid (8). The chemical structure of these compounds was elucidated by spectroscopic analysis as well as high resolution ESI-MS analysis and comparison with those reported in the literature. Among these compounds, (1), (2), (4), (5) and (7) were the first time known in the Ramalina genus. Although compound (7) was detected in the lichen Neofuscelia depsidella by chromatographic comparisons with authentic material that was synthesized by condensation of the benzoic acid and 3-methoxyl-5propylphenol but it is isolated in the nature for the first time. The results of determining the α-glucosidase inhibitory activity of four isolated compounds show that the α-glucosidase inhibitory effect of (8) was the best with IC50 values in 136.62 μg/mL (compared with the control acarbose IC50 93.63 μg/mL).

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Section: α-Glucosidase Inhibition Assaymentioning

confidence: 99%

Section: α-Glucosidase Inhibition Assaymentioning

confidence: 99%

Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

Linh¹,

Danova

Truong

et al. 2020

Vietnam Journal of Chemistry

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show abstract

“…The inhibition of α-glucosidase was examined using a method explained by Ramadhan et al [20]. The aforementioned protocol was used to determine the inhibitory reaction of these isolated compounds against maltase from rat intestine and sucrase.…”

Section: α-Glucosidase Inhibitory Activitiesmentioning

confidence: 99%

Antidiabetes and Antioxidant agents from Clausena excavata root as medicinal plant of Myanmar

et al. 2019

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All around the world, patients with diabetes and the prevalence of its disease are currently growing. Due to these side effects of oral hypoglycemic agents and oxidative stress in complicating diabetes, there is growing interest in drugs, which possess dual function as both type II diabetes mellitus treatment and oxidative stress treatment. The objective of this research is to search effective antidiabetes and antioxidant bioactive compounds from the Myanmar medicinal plant Clausena excavata. The root part of C. excavata was successfully extracted with 95% ethanol and followed by column chromatographic separation technique. The structure of isolated pure compounds was elucidated by using methods of spectroscopic such as UV-Vis, IR, NMR and HRFABMS spectrometry. The α-glucosidase inhibition assay was performed against baker's yeast and rat intestine (sucrose and maltase) α-glucosidases. The activity of isolated compounds' antioxidant was measured by using DPPH assay. Among the tested enzymes, the two isolated compounds, which were dentatin (1) and heptaphylline (2), exhibited highest inhibitory on maltase enzymes with IC 50 values 6.75 and 11.46 µM; as positive control, acarbose (IC 50 , 2.35 µM) was utilized. Moreover, scavenging activity was found to be present upon seeing the result of antioxidant activity investigation of (1) and (2) (IC 50 values 2.66 and 1.55 mM), where ascorbic acid (IC 50 0.012 mM) was used as standard. Both compounds showed their antidiabetic and antioxidant activity with different fashion, especially exhibited strongest activity against on maltase α-glucosidase.

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“…The thionation reaction was carried out by the action of phosphorus pentasulfide on the pyrazolo[3,4-d]pyrimidine (a) in pyridine [9]. The reaction leads to pyrazolo […”

Section: Thionation Of 1h-pyrazolo[34-d]pyrimidin4(5h)-onementioning

confidence: 99%

“…Inhibitors of α-amylase and αglucosidase can delay the digestion of carbohydrates in the small intestine and reduce the level of postprandial blood glucose [7]. Many studies have searched for safe and effective inhibitors of α-amylase and α-glucosidase from medicinal plants to treat T2DM [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

et al. 2017

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A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and αglucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for αamylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for αglucosidase.

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New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals

Cited by 49 publications

References 17 publications

Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

Antidiabetes and Antioxidant agents from Clausena excavata root as medicinal plant of Myanmar

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

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