New aspects the regulation of immune response through balance Th1/Th2 cytokines

Tymoshok, N. O.; Лазаренко, Л. М.; Bubnov, Rostyslav; Shynkarenko, Liudmyla N; Babenko, Lidia P; Mokrozub, Viktoria V; Melnichenko, Yulia A; Spivak, Mykola

doi:10.1186/1878-5085-5-s1-a134

Cited by 11 publications

(4 citation statements)

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“…According to our recent data [ 110 ], daily oral administration of strains L. rhamnosus V ® or L. rhamnosus LB3 IMB B-7038 (1 × 10 6 cells / mouse) for 4 days and infected Staphyloccous aureus 8325 mice in a dose (5 × 10 8 CFU/mouse) LD50 was accompanied by a reduction in the mortality of animals. The introduction of lactic acid bacteria to the animals infected with S. aureus allowed increased functional activity of phagocytic system and the normalization parameters of cellular immunity activation and production of interferon-γ and IL-12 in different periods of observation.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

et al. 2014

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IntroductionObesity becomes endemic today. Monosodium glutamate was proved as obesogenic food additive. Probiotics are discussed to impact on obesity development.Aims and objectivesThe aim was to study the effects of probiotics on the development of monosodium glutamate (MSG)-induced obesity in rats.Material and methodsWe included 45 Wistar male rats and divided into three groups (n = 15). Newborn rats of group 1 (control) received subcutaneously 8 μl/g saline. Group 2 received 3 to 4 mg/g MSG subcutaneously on the second, fourth, sixth, eighth and tenth day of life. Within 4 months after birth, rats were on a standard diet. Group 3 received an aqueous solution of probiotics mixture (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, B. animalis VKB) at the dose of 5 × 109 CFU/kg (50 mg/kg) intragastrically. Administration of probiotics was started at the age of 4 weeks just after weaning and continued for 3 months during 2-week courses. Group 2 received intragastrically 2.5 ml/kg water. Organometric and biochemical parameters in all groups of rats were analyzed over 4 months. The concentration of adiponectin was determined in serum, and leptin - in adipose tissue.ResultsAdministration of MSG led to the development of obesity in rats; body weight had increased by 7.9% vs controls (p < 0.05); body length had increased by 5.4% (p < 0.05). Body mass index and Lee index and visceral fat mass had increased (p < 0.001). Under the neonatal injection of MSG, the concentration of total cholesterol, triglycerides, VLDL cholesterol and LDL cholesterol significantly increased (p < 0.001), in comparison with controls. Adipose-derived hormones changed in MSG obesity rats: adiponectin decreased by 58.8% (p < 0.01), and leptin concentration in adipose tissue had increased by 74.7% (p < 0.01). The probiotic therapy of rats from group 3 prevented obesity development. Parameters of rats treated with probiotic mixture did not differ from that in the control.ConclusionsThe introduction of MSG to newborn rats caused the obesity in adulthood. Periodic administration of probiotic mixture to rat injected with MSG neonatally resulted in recovery of lipid metabolism and prevention of the obesity development.

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Section: Discussionmentioning

confidence: 99%

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

et al. 2014

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“…But probiotic preparations are capable of activating both (Th1 and Th2) lymphocyte subpopulations, which provides a balance of cytokine production. Immunomodulatory activity of probiotic preparations most important to identify for the goods induced opposite cytokines IL-10 or IL-12 in experiments in vitro when stimulated macrophage cells [82]. The immune response against infectious diseases of probiotic drugs due to the ability to balance the body's immune status at the level of receptor-ligand interactions [82].…”

Section: Cytokine Profiles Of Toll-like Receptorsmentioning

confidence: 99%

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Bubnov¹,

Spivak²

2018

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

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“…They have protective effects against a range of diseases such as allergies, tumors, diabetes, inflammation of the gastrointestinal tract and nervous system disorders. The effects of probiotics are significantly exerted by regulating cytokine gene expression, regulating the immune system, enhancing mucosal barrier function, and competing with pathogenic bacteria [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial

Sadrifar

Abbasi-Dokht

Forouzandeh

et al. 2023

Allergy Asthma Clin Immunol

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Background Asthma is considered to be a chronic inflammatory disorder of the airways. Probiotics are living microorganisms that are found in the human gut and have protective effects against a wide range of diseases such as allergies. The aim of this study was to investigate the improvement of clinical asthma symptoms and changes in the expression pattern of selective microRNAs in patients with asthma and the changes in IL-4 and IFN-γ plasma levels after receiving probiotics. Materials and methods The present study was a randomized, double-blind, placebo-controlled trial that enrolled 40 asthmatic patients. They were treated with probiotics or placebo: 1 capsule/day for 8 weeks. Pulmonary function tests, IL-4 and IFN-γ levels, and expression of microRNAs were assessed at baseline and after treatment. Results The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. In addition, pulmonary function tests showed a significant improvement in Forced Expiratory Volume in 1 s and Forced Vital Capacity after receiving probiotics. Conclusion In our study, 8-week treatment with probiotic supplementation led to reduced Th2 cells-associated IL-4 and improved Forced Expiratory Volume and Forced Vital Capacity. It appears probiotics can be used in addition to common asthma treatments.

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New aspects the regulation of immune response through balance Th1/Th2 cytokines

Cited by 11 publications

References 0 publications

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial

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