New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents

Głowińska, Barbara; Urban, Mirosława; Koput, Alicja; Galar, Marzenna

doi:10.1016/s0021-9150(03)00003-0

Cited by 101 publications

(105 citation statements)

References 43 publications

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“…Increased BMI and adiposity are accompanied by increases in heart rate, 16 BP, 17 and intermediary CV metabolic risk factors such as insulin resistance, 18 dyslipidemia, 19 and inflammation. 20 Such factors may mediate alterations in arterial function.…”

Section: Discussionmentioning

confidence: 99%

Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children

et al. 2009

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Abstract-Childhood obesity is increasingly prevalent in the community and is related to adverse cardiovascular outcomes during adulthood. In this study of healthy children, we evaluated the influence of adiposity and physical activity on carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness and a marker of cardiovascular risk in adults. In 573 community-based children (mean age: 10.1Ϯ0.3 years; 51% boys), we measured body mass index and waist circumference. Percentage body fat was quantitated by dual-energy x-ray absorptiometry. Cardiorespiratory fitness (CRF) and physical activity levels were assessed using a 20-m shuttle run and 7-day pedometer count, respectively. PWV was estimated by applanation tonometry. In univariate analysis, PWV was positively correlated with body mass index (rϭ0.34), waist circumference (rϭ0.32), and percentage body fat (rϭ0.32; PϽ0.001 for all) and negatively correlated with CRF (rϭϪ0.23; PϽ0.001) and pedometer count (rϭϪ0.08; Pϭ0.046). In separate multivariable linear regression models, body mass index, waist circumference, and percentage of body fat were independently and positively associated with PWV (PϽ0.01 for all) after adjusting for age, sex, systolic blood pressure, mean arterial pressure, heart rate, and CRF (PϽ0.01 for all). The influence of CRF on PWV was attenuated after adjusting for adiposity. In conclusion, increased body mass and adiposity and decreased CRF are associated with arterial stiffening in healthy prepubescent children.

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Section: Discussionmentioning

confidence: 99%

Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children

et al. 2009

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“…Homocysteine has been considered an important risk factor for coronary artery disease 25 and although the homocysteine levels appear to have a direct association with insulin levels in obese children and adolescents 26 , there was an inverse correlation between insulin (r=-0.233; p<0.05) and HOMA-IR (r=-0.215; p<0.05). However, no correlation was observed between homocysteine and the body composition variables and most of the metabolic variables.…”

Section: Faria Et Al Metabolic Alterations In Adolescentsmentioning

confidence: 99%

Correlação entre variáveis de composição corporal e metabólica em adolescentes do sexo feminino

Faria¹,

Franceschini²,

Pelúzio³

et al. 2009

Arq. Bras. Cardiol.

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“…It was not significant at ages less than 50 years, significant between 50 and 70 years, and not significant at ages above 70 years. Glowinska et al, [16] haven't found a significant difference in the gradual increase of the hyperhomocysteinemia during the early stages of the macrovascular complications of the diabetes. This could explain the no significant increase in hyperhomocysteinemia at ages less than 50 years.…”

Section: Discussionmentioning

confidence: 95%

Hyperhomocysteinemia and Type 2 Diabetes in Côte d'Ivoire

JJ¹,

AL²

2018

IJFS

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New atherosclerosis risk factors in obese, hypertensive and diabetic children and adolescents

Cited by 101 publications

References 43 publications

Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children

Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children

Correlação entre variáveis de composição corporal e metabólica em adolescentes do sexo feminino

Hyperhomocysteinemia and Type 2 Diabetes in Côte d'Ivoire

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