New basic insights on the potential of a chitosan‐based medical device for improving functional recovery after radical prostatectomy

Muratori, Luísa; Fregnan, Federica; Ronchi, Giulia; Haastert‐Talini, Kirsten; Metzen, Jennifer; Bertolo, Riccardo; Porpiglia, Francesco; Geuna, Stefano

doi:10.1111/bju.14834

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…22 The same group also assessed the functional characteristics of the chitosan membrane, including neurogenerative effect, modifying effect, and tissue reaction using the preclinical models. 23 In the study, they confirmed that the functional effects of an implanted material using a grasping test of a rat median nerve model. 23 In contrast, we successfully developed the cavernous nerve damage model in a rat and confirmed the effectiveness of ALG with PGA mesh in restoring the erectile function after cavernous nerve excision, suggesting that the efficacy of our novel material in enhancing the autonomic nerve regeneration along with somatic nerve regeneration.…”

Section: Discussionsupporting

confidence: 52%

Cavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model

Narita

Obara

Ishikawa³

et al. 2021

Sexual Medicine

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Introduction: Neuroprotection and neuroregeneration of cavernous nerve plexus by biological/bioengineering solutions may have the potential to maintain erectile function. Aims: We evaluated the efficacy of a newly developed artificial nerve sheet using freeze-dried alginate (ALG) with polyglycolic acid (PGA) mesh in a rat model. Methods: Bilateral cavernous nerves of male rats were excised to make an approximately 2 mm gap. A piece of the sponge-like freeze-dried sheet created by covalent cross-linking of ALG gel combined with PGA mesh was placed over the gap to cover each stump without any neural anastomosis. We compared erectile functions in the ALG groups with those in the sham group and the bilateral nerve excision group (n ¼ 12, each). Main Outcome Measures: Main outcome measure was a rat model with cavernous nerve excision. Results: All rats in the sham group had erection at 63 or 64 days, and mating behavior was confirmed in 10 rats (83.3%) of the sham group at 56 to 62 days. No erection and mating behavior was observed in the excision group. Ten of the 12 (83.3%) rats in the ALG group had a mating behavior and an erection, and the rates of erection and mating behavior were significantly higher in the ALG group than those in the excision group (P < .01, P < .01, respectively). Using a retrograde FluoroGold, the rate of FluoroGold positive pelvic ganglia proximal to the gap at 61 or 62 days was significantly higher in the ALG group than that in the excision group (P ¼ .014). Conclusion:The results of our animal study have demonstrated that simply filling the cavernous nerve gap using the non-tubular artificial nerve sheets made of ALG with PGA mesh restored erectile function after cavernous nerve excision.

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Section: Discussionsupporting

confidence: 52%

Cavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model

Narita

Obara

Ishikawa³

et al. 2021

Sexual Medicine

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“…These studies validated SilkBringe TM , safety and its beneficial effect on median nerve recovery [ 80 , 81 ]. These groups are specialized in nerve tissue engineering and regeneration: they have produced several works on decellularized nerve grafts [ 82 ], neuronal grafts conduits based on synthetic biomaterials (PLC and polyhydroxyalkanoates) [ 83 , 84 ], and other nerve regeneration techniques [ 85 , 86 ].…”

Section: Application Fieldsmentioning

confidence: 99%

Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Camponogara

Zanotti

Tiengo

et al. 2022

IJMS

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Regenerative medicine is the branch of medicine that effectively uses stem cell therapy and tissue engineering strategies to guide the healing or replacement of damaged tissues or organs. A crucial element is undoubtedly the biomaterial that guides biological events to restore tissue continuity. The polymers, natural or synthetic, find wide application thanks to their great adaptability. In fact, they can be used as principal components, coatings or vehicles to functionalize several biomaterials. There are many leading centers for the research and development of biomaterials in Italy. The aim of this review is to provide an overview of the current state of the art on polymer research for regenerative medicine purposes. The last five years of scientific production of the main Italian research centers has been screened to analyze the current advancement in tissue engineering in order to highlight inputs for the development of novel biomaterials and strategies.

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Autonomic Nervous System Repair and Regeneration

Muratori

Fregnan

Carta

et al. 2021

Peripheral Nerve Tissue Engineering and Regeneration

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New basic insights on the potential of a chitosan‐based medical device for improving functional recovery after radical prostatectomy

Cited by 6 publications

References 36 publications

Cavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model

Cavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model

Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Autonomic Nervous System Repair and Regeneration

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