New Benzoxazine Secondary Metabolites from an  Arctic Actinomycete

Moon, Kyuho; Ahn, Chan‐Hong; Shin, Yeong Gil; Won, Tae Hyung; Ko, Kwang Wook; Lee, Sang Kook; Oh, Ki‐Bong; Shin, Jongheon; Nam, Seung‐Il; Oh, Dong‐Chan

doi:10.3390/md12052526

Cited by 38 publications

(31 citation statements)

References 20 publications

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“…For example, the Streptomyces sp. ART5 strain, isolated from Eastern Siberia sediments, shows inhibitory activity against Candida albicans (Moon et al ., ). A significant finding is that of Augustine and colleagues () who identified three species of Arctic Actinomycetes, two Streptomyces species and one Nocardiopsis species, isolated from sediments in Svalbard, with the potential to inhibit Vibrio cholerae biofilms.…”

Section: Importance Of Understanding Arctic Microbial Biogeographymentioning

confidence: 97%

Microbial diversity and biogeography in Arctic soils

Malard

Pearce

2018

Environ Microbiol Rep

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Microorganisms dominate terrestrial environments in the polar regions and Arctic soils are known to harbour significant microbial diversity, far more diverse and numerous in the region than was once thought. Furthermore, the geographic distribution and structure of Arctic microbial communities remains elusive, despite their important roles in both biogeochemical cycling and in the generation and decomposition of climate active gases. Critically, Arctic soils are estimated to store over 1500 Pg of carbon and, thus, have the potential to generate positive feedback within the climate system. As the Arctic region is currently undergoing rapid change, the likelihood of faster release of greenhouse gases such as CO , CH and N O is increasing. Understanding the microbial communities in the region, in terms of their diversity, abundance and functional activity, is key to producing accurate models of greenhouse gas release. This review brings together existing data to determine what we know about microbial diversity and biogeography in Arctic soils.

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Section: Importance Of Understanding Arctic Microbial Biogeographymentioning

confidence: 97%

Microbial diversity and biogeography in Arctic soils

Malard

Pearce

2018

Environ Microbiol Rep

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“…The new benzoxazine glycosides, arcticoside ( 64 ) and C‐1027 chromophore‐V ( 65 ) derived from an Arctic marine Streptomyces strain showed inhibitory activity against Candida albicans isocitrate lyase and breast and colorectal carcinoma cells. Additionally, C‐1027 chromophore‐III ( 66 ) and fijiolides A and B ( 67 , 68 ) were isolated from the same strain (Moon et al ). An Arctic freshwater‐derived bacterium, Pseudomonas fluorescens BD5 produced unusual cyclic lipopeptide biosurfactants, namely pseudofactin I and II ( 69 , 70 ), the structure of which is unique as a palmitic acid is connected to a terminal peptide moiety of eighth amino acids.…”

Section: Permafrost Soilsmentioning

confidence: 99%

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

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Summary The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep‐sea sediments select for micro‐organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro‐organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot‐spots of novel gifted micro‐organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial‐derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.

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“…Compounds 30 and 31 inhibited Candida albicans isocitrate lyase, an enzyme that plays an important role in the pathogenicity of C. albicans. Furthermore, 31 exhibited significant cytotoxicity against breast carcinoma MDA-MB231 cells and colorectal carcinoma HCT-116 cells, with IC 50 values of 0.9 and 2.7 μM, respectively [27]. …”

Section: Microorganismsmentioning

confidence: 99%

Secondary Metabolites from Polar Organisms

Tian

Zhao

2017

Marine Drugs

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Polar organisms have been found to develop unique defences against the extreme environment environment, leading to the biosynthesis of novel molecules with diverse bioactivities. This review covers the 219 novel natural products described since 2001, from the Arctic and the Antarctic microoganisms, lichen, moss and marine faunas. The structures of the new compounds and details of the source organism, along with any relevant biological activities are presented. Where reported, synthetic and biosynthetic studies on the polar metabolites have also been included.

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New Benzoxazine Secondary Metabolites from an Arctic Actinomycete

Cited by 38 publications

References 20 publications

Microbial diversity and biogeography in Arctic soils

Microbial diversity and biogeography in Arctic soils

Extreme environments: microbiology leading to specialized metabolites

Secondary Metabolites from Polar Organisms

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