New Bifunctional Diarylethene Sensor for Multianalyte Detection and Al³⁺ Imaging in Live Cells

Abstract

A novel photochromic diarylethene bifunctional chemosensor with a hydroxybenzylidene-2-naphthohydrazide group was synthesized with multicontrollable and photoswitchable properties, induced by UV–vis light, acid/base, and metal ions in acetonitrile. The deprotonated derivative of the compound showed good photochromism and notable fluorescence enhancement. It could serve as a “naked-eye” colorimetric sensor for Ni2+. Moreover, its fluorescence was enhanced by 75-fold, turning from dark to bright jade green, upon the addition of Al3+. The compound formed complexes with Ni2+ and Al3+ in a 1:1 stoichiometry and could detect these metal ions at concentrations as low as 1.67 × 10–5 and 9.45 × 10–8 mol L–1, respectively. Additionally, it can penetrate into HeLa cells and can be used for the detection of intracellular Al3+.

A highly selective multi-responsive fluorescence sensor for Zn2+ based on a diarylethene with a 4,6-dimethylpyrimidine unit

“…The result elucidated that two isomers of 1 had large affinity for Zn 2+ and readily competes with EDTA for Zn 2+ resulting in the irreversible response of 1O and 1C to Zn 2+ . 50 In general, in order to detect metal ions, chemosensors bind with the target metal ions through non-covalent interactions to yield stable coordination complexes. 51 The Zn 2+ ion should have a stronger binding energy to the sensor 1 than EDTA.…”

A bifunctional sensor based on diarylethene for the colorimetric recognition of Cu2+ and fluorescence detection of Cd2+

“…It is noteworthy that Cu 2+ could signicantly quench the uorescence of 1o-Cd 2+ , which may be due to its paramagnetism. 58 The uorescence titration of 1o with Cd 2+ was performed in THF at room temperature. As shown in Fig.…”

N-Doped Carbon Dots Derived from Melamine and Triethanolamine for Selective Sensing of Fe3+ Ions

“…In detecting metal ions, fluorescence methods have benefits such as high sensitivity, reusability, onsite usage, and relatively economical, over traditional spectrophotometric approaches, which generally require complex sample preparation procedures and expensive instrumentation [31,32]. Even though several fluorescent sensors have been reported in the literature [33][34][35][36][37], only very few highly selective and susceptible detection of Fe 3+ ions with reusability exists [36,37].…”